Apomorphine and electrical self-stimulation of rat brain

Fouriezos, George; Francis, Stewart

doi:10.1016/s0166-4328(05)80326-2

Cited by 25 publications

(15 citation statements)

References 22 publications

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“…Cocaine and amphetamine, which increase synaptic dopamine levels, increase the rate of ICSS responding and induce a leftward shift in frequencyresponse curves (Gallistel and Karras 1984;Hatcher et al 1995). This shift is thought to reßect the rewarding properties of these drugs, and similar potentiation has been reported for the dopamine receptor agonists quinpirole (Nakajima et al1993;Ranaldi and Beninger 1994a,b), apomorphine (Fourriezos and Francis 1992) and bromocriptine (Knapp and Kornetsky 1994).…”

Section: Introductionmentioning

confidence: 61%

“…For example, apomorphine has been reported to have a biphasic e¤ect, decreasing reward thresholds at high doses (0.31.0 mg / kg) and increasing them at lower doses (0.01 0.1 mg / kg) (Fourriezos and Francis 1992). Quinpirole and (±)7-OH-DPAT are also reported to reduce ICSS response levels according to some studies (Gilbert et al 1995;Kling-Petersen et al 1995;Depoortee et al1996).…”

Section: Introductionmentioning

confidence: 95%

“…It has been suggested by Fourriezos and Francis (1992) that the biphasic response to apomorphine reßects a switch from presynaptic e¤ects, thought to dominate at low doses, to post-synaptic e¤ects which dominate at higher doses. However, following advances in molecular biology and the discovery of the D 1 , D 2 , D 3 , D 4 and D 5 receptor subtypes (Sokolo¤ et al 1990;Sunahara et al 1991;Van Tol et al 1991) an alternative hypothesis is that di¤erent receptor subtypes mediate the two components of the biphasic response.…”

Section: Introductionmentioning

confidence: 99%

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The effects of dopamine D 3 /D 2 receptor agonists on intracranial self stimulation in the rat

Hatcher

Hagan

1998

Psychopharmacology

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The effects of the dopamine D3/D2 receptor agonists quinpirole, quinelorane and (+/-)7-OH-DPAT [(+/-) 7-hydroxy-2(N,N-di-n-propylamino) tetralin] on intracranial self-stimulation (ICSS) were investigated. Rats implanted with bipolar electrodes into the lateral hypothalamus were trained to lever press on a continuous reinforcement schedule for positively reinforcing trains of electrical stimulation. Three measures of responding were calculated; the frequency at which responding was 50% of the maximum (M50), the asymptotic response rate and the total area under the curve (AUC) for each frequency sweep. Quinpirole (2.2-66.0 microg/kg SC) significantly increased M50 and reduced both asymptote and AUC. Quinelorane (0.25-79.0 microg/kg SC) had no significant effect on M50 values but significantly reduced both asymptote and AUC. (+/-)7-OH-DPAT (2.5-74.0 microg/kg) did not significantly affect any of the measures. The data show that low doses of quinpirole and quinelorane, but not (+/-)7-OH-DPAT, inhibit ICSS maintained by electrodes in the lateral hypothalamus. Either dopamine D2 or dopamine D3 receptor stimulation may play a role in mediating ICSS inhibition, but studies with more selective receptor agonists and antagonists are required to define the role of each receptor.

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Section: Introductionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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The effects of dopamine D 3 /D 2 receptor agonists on intracranial self stimulation in the rat

Hatcher

Hagan

1998

Psychopharmacology

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“…However, one study [49] demonstrated similar increases in reward threshold using quinpirole at doses in the same range as those at which we also observe elevations in BSR threshold, although that study did not test doses higher than 0.066 mg/kg. Apomorphine, an agonist with similar affinity for D2 and D1 receptors [50,51], also increases BSR threshold at low doses (0.01-0.1 mg/kg) and decreases threshold at higher doses (0.3-1.0 mg/kg) [52]. We observe clear increases in BSR threshold following low doses of quinpirole (0.1-0.3 mg/kg) and decreases in threshold at higher doses (1.0-10 mg/kg).…”

Section: Discussionmentioning

confidence: 98%

Prenatal Exposure to Cocaine Increases the Rewarding Potency of Cocaine and Selective Dopaminergic Agonists in Adult Mice

Malanga

Riday

Carlezon

et al. 2008

Biological Psychiatry

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“…One pervading theory regarding DA's role in controlling reward and reinforcement is that DA mediates the salience of reward stimuli [30]. High doses of APO in rodents have been shown to reduce reward seeking behavior [31,32]. In this study, the 5-minute inter-trial interval served as a "reward" for successfully climbing onto the platform.…”

Section: Discussionmentioning

confidence: 94%

Apomorphine effects on frog locomotor behavior

Chu

Wilczynski

2007

Physiology & Behavior

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The neuroanatomical pathways of the DA systems have been shown to be largely conserved across many vertebrate taxa. It is less certain whether the structural similarities seen between mammals and amphibians reflect a similar functional homology. DA is well known for its role in facilitating motor behaviors in mammals. We examined whether a similar role for DA exists in amphibians using the Northern Leopard Frog (Rana pipiens). We investigated the effects of the nonspecific DA agonist, apomorphine (APO) on a complex motor task that included two distinct components known to be differentially modulated by DA in mammals: swimming and climbing. We demonstrated that a high single dose of APO (20 mg/kg, body weight) strongly increased the amount of time spent completing the motor task. Furthermore, we showed that although APO did not significantly alter several aspects of swimming behavior, two aspects of climbing behavior were disrupted. Both climbing speed and climbing ability were impaired by APO treatment. These results increase our understanding of DA function in amphibians and add to our understanding of structure-function homologies of dopamine function across vertebrate taxa. KeywordsRana pipiens; Amphibian; Apomorphine; Dopamine; Evolution; Comparative; Locomotion; Motor behavior; Catecholamine; Basal ganglia; Swimming; Climbing The neurotransmitter dopamine (DA) is known for its classic behavioral roles that include regulation of locomotion, mediation of reward and reinforcement behaviors and modulation of sex-specific behaviors. These behaviors have been shown to depend on DA circuits in the nigrostriatal pathway, mesolimbic pathway and medial preoptic area, respectively. Neuroanatomical studies of major vertebrate taxonomic groups provide strong evidence that DA pathways and cell populations are anatomically conserved across amniotes -mammals, birds and reptiles, and anamniotes -amphibians and fish [1]. Among studies of amphibians, developmental, hodological, and immunocytochemical studies have shown that anurans (frogs and toads) possess several DA cell populations homologous to those in mammals, including dopaminergic cell populations in the preoptic area, suprachiasmatic nucleus (believed to homologous to the mammalian arcuate nucleus cell population) and at the diencephalicmidbrain border adjacent to the posterior tuberculum [2,3]. Marin et al. has shown that this midbrain DA population in anurans is connectionally most similar to the substantia nigra (A9) and ventral tegmental area (A10) of mammals and forms the DA input of the basal ganglia [2]. In addition to the DA pathways of the basal ganglia, much of the cytoarchitecture and neurochemistry of the striatum, as well as its afferent and efferent connections are also strongly conserved across major vertebrate taxa [4].

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Apomorphine and electrical self-stimulation of rat brain

Cited by 25 publications

References 22 publications

The effects of dopamine D 3 /D 2 receptor agonists on intracranial self stimulation in the rat

The effects of dopamine D 3 /D 2 receptor agonists on intracranial self stimulation in the rat

Prenatal Exposure to Cocaine Increases the Rewarding Potency of Cocaine and Selective Dopaminergic Agonists in Adult Mice

Apomorphine effects on frog locomotor behavior

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