Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns

Katulanda, Gaya; Katulanda, Prasad; Adler, Amanda I; Peiris, S R; Draisey, I; Wijeratne, Sumedha; Sheriff, Rezvi; Shine, Brian

doi:10.1258/acb.2009.009080

Cited by 7 publications

(4 citation statements)

References 24 publications

(30 reference statements)

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“…23 In this study, Apo B/Apo A-I ratio shown good association with cardiometabolic risk markers, the positive correlation with various variables of study was observed except for HDL-C and Apo A-I. This study showed that, LDL, TC and TG were positively correlated with Apo-B and Apo-B was negatively correlated with HDL-C are in keeping with Kumar S et al 24 , and Katulanda GW et al 25 The combined effect of Apo B and Apo A-I is realized in the Apo B/Apo A-I ratio which showed a highly signi cant correlation with cardiometabolic risk biomarkers. Recent studies have used the Apo B/Apo A-I ratio is associated with cardiometabolic risk biomerkers.…”

Section: Discussionsupporting

confidence: 86%

Association of Apolipoprotein B /Apolipoprotein A-I Ratio With Cardiometabolic Risk Biomarkers in Type 2 Diabetes Mellitus

Makaju

Sharma

Yadav

et al. 2022

Preprint

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Background Patients with Type 2 Diabetes mellitus and metabolic syndrome have increased risk for cardiovascular disease (CVD). Measuring the Apolipoprotein B (Apo B) can accurately estimate the atherogenic particles whereas Apolipoprotein A-I (Apo A-I) is the major structural constituent of antiatherogenic high-density lipoproteins. Early analysis of cardiometabolic risk reduces the chance of CVD. Objectives The aim of this study was to evaluate the association of Apo B/Apo A-I ratio with cardiometabolic risk biomarkers in T2DM. Material and Methods This cross sectional study conducted at Tribhuvan University Teaching Hospital, included 120 diagnosed with type 2 diabetes Mellitus visiting Medicine OPD and 120 apparently healthy controls. Clinical and anthropometric characteristics were documented using clinical proforma. The fasting blood samples were collected for estimating serum glucose, Apo B, Apo A-I, traditional lipid profile analysis and Apo B/Apo A-I ratio were calculated. Results The mean values of cardiometabolic risk biomarkers and Apo B/Apo A-I ratio in patents with T2DM were significantly higher whereas HDL-C was significantly lower than that of a control group (p ≤ 0.001). There was a strong positive correlation between the Apo B/Apo A-I ratio and LDL-C, TC, Non HDL-C, and Apo B (r = 0.68–0.89, p < 0.001). Similarly, modest positive correlation was found with BMI, WC, TG and VLDL-C (r = 0.55–0.67, p < 0.001) and a weak, yet significant, correlation (r = 0.18–0.35 p < 0.05) with weight, systolic blood pressure and FBG. In contrast, the ratio showed negative correlation with HDL-C and Apo A-I (r = -0.58, p < 0.001). Conclusion: The present study demonstrated that an elevated Apo B/Apo A-I ratio constituted a good association with cardiometabolic biomarkers and supports that the Apo B/Apo A-I ratio as a promising risk marker of future cardiovascular disease as it is not interfered by dietary variation of lipid intake during investigation.

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Section: Discussionsupporting

confidence: 86%

Association of Apolipoprotein B /Apolipoprotein A-I Ratio With Cardiometabolic Risk Biomarkers in Type 2 Diabetes Mellitus

Makaju

Sharma

Yadav

et al. 2022

Preprint

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“…Since women with diabetes have a higher rate of mortality from cardiovascular disorders than men [7], it could be hypothesized that increased levels of serum Lp(a) in women with diabetes, may be one of the mechanisms for this observation. On the other hand, one could think that these results are affected by the gender effect on serum Lp(a) levels which is demonstrated by population based studies [40]. We showed that the odds ratio of having a serum Lp(a) level higher than 35 was 5.85 in premenopausal women with diabetes, 5.08 in postmenopausal women with diabetes, 2.41 in men with diabetes and 1.9 in women of the control group compared to men of the control group, when adjusting for age and BMI.…”

Section: Discussionmentioning

confidence: 98%

Serum Lipoprotein(a) Levels are Greater in Female than Male Patients with Type‐2 Diabetes

Nakhjavani¹,

Morteza²,

Esteghamati³

et al. 2010

Lipids

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Women with diabetes are faced with a higher risk of dyslipidemia and cardiovascular disorders than men with diabetes. We aimed to study the role of gender and menopausal status in serum Lp(a) levels in patients with type 2 diabetes. We quantified serum Lp(a) levels in a group of 477 patients with type 2 diabetes (men, premenopausal and postmenopausal women with diabetes), as well as in 105 controls. We stratified the patients into two groups of low Lp(a) levels (Lp(a) <35 mg/dl) and elevated Lp(a) levels (Lp(a) >35 mg/dl). Patients with diabetes had higher serum Lp(a) levels than the controls. Serum Lp(a) levels was significantly higher in women with diabetes than men with diabetes. Lp(a) levels did not differ between male and females in the control group. Premenopausal and postmenopausal women with diabetes did not differ significantly in serum Lp(a) levels. The odds ratio of having a serum Lp(a) level higher than 35 was 5.85 in premenopausal women with diabetes, 5.08 in postmenopausal women with diabetes, 2.41 in men with diabetes and 1.9 in the women in the control group compared to the men in the control group, after adjustment for age and BMI. This observational study clearly indicated that serum Lp(a) levels were significantly higher in women and men with diabetes. The increase in women was independent of menopause. The level of serum Lp(a) had no correlation with lipid parameters in men or women.

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“…Katulanda G et al, found that patients with type 2 diabetes had atherogenic lipid profiles [32]: elevated ApoB often accompanied by elevated TG, high Apo B100/ Apo A1 ratio and low LDL: Apo B 100 ratio. Sniderman AD et al, found in 249 Canadian subjects that 23% had abnormal LDL [33], i.e., an elevated LDL cholesterol level; almost 40% has an elevated Apo B and therefore an elevated LDL particle number.…”

Section: Discussionmentioning

confidence: 99%

Levels of Apolipoprotein A1, B100 and Lipoprotein (a) in Controlled and Uncontrolled Diabetic Patients and in Non-Diabetic Healthy People

Patel

Makadia

et al. 2017

JCDR

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Introduction: Diabetes Mellitus (DM) is always a multifactorial metabolic disorder having a wide range of abnormalities in carbohydrate, lipid and protein metabolism. Dyslipidemia is a natural process of DM causing abnormal variations of different lipoproteins and it is one of the significant risk factors for Cardiovascular Disorder (CVD). There is a need to closely evaluate newer approaches in case of DM because even if dyslipidemia is treated, there is always a risk of CVDs in DM patients because of the hyperglycemia itself. So, lipid abnormalities should be assessed aggressively and treated as part of diabetes care. Apolipoprotein B100 (Apo B100), Apolipoprotein A1 (Apo A1) and Lipoprotein (a) {Lp(a)} are newer markers which are always welcome and necessary as many of the reported cases with normal conventional lipid profile have developed cardiac events.Aim: Study the correlation between glycemic control and the levels of Apo A1, Apo B100 and Lp(a). Materials and Methods :Total 56 patients of (DM) diagnosed on the basis of American Diabetic Association guidelines were recruited, out of which 28 were identified as uncontrolleddiabetic patients and remaining 28 as controlled-diabetics on the basis of Glycosylated HbA1c (HbA1c). The control group consisted of normal healthy 28 individuals. Apo B100, Apo A1 and Lp(a) along with traditional lipid profile, Fasting Blood Sugar (FBS) and HbA1c were estimated in all the subjects.Results: Apo B100/Apo A1 ratio and Lp(a) levels showed highly significant difference (p-value <0.001) between uncontrolled diabetics, controlled diabetics and healthy Controls. Apo B100/ Apo A1 ratio and Lp(a) showed significant positive correlations with HbA1c (r= 0.494, p <0.0001) and with each other. Conclusion:Apo B100/Apo A1 ratio and Lp(a) show a highly significant positive relationship with glucose tolerance of the patients as reflected in the HbA1c values. If proper glycemic control is maintained, the levels of Apo B100/Apo A1 ratio and Lp(a) can be controlled as reflected by the lower levels of these parameters observed in controlled diabetics in comparison to uncontrolled diabetics.Vishwal Indravadan Patel et al., Apolipoproteins and Lipoprotein(a) in Diabetes Mellitus www.jcdr.net

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Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns

Abstract: A large proportion of young adult Sri Lankan patients with type 2 diabetes has a low LDLC:apoB and high apoB and/or TG, suggesting that these patients are at increased risk of CVD.

Cited by 7 publications

References 24 publications

Association of Apolipoprotein B /Apolipoprotein A-I Ratio With Cardiometabolic Risk Biomarkers in Type 2 Diabetes Mellitus

Association of Apolipoprotein B /Apolipoprotein A-I Ratio With Cardiometabolic Risk Biomarkers in Type 2 Diabetes Mellitus

Serum Lipoprotein(a) Levels are Greater in Female than Male Patients with Type‐2 Diabetes

Levels of Apolipoprotein A1, B100 and Lipoprotein (a) in Controlled and Uncontrolled Diabetic Patients and in Non-Diabetic Healthy People

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