Apolipoprotein E genotype distribution in schizophrenia

Zhu, S.; Nöthen, M. M.; Uhlhaas, Siegfried; Rietschel, Marcella; Körner, Judith; Lanczik, M.; Fimmers, R.; Propping, Peter

doi:10.1097/00041444-199622000-00007

Cited by 24 publications

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“…In contrast, the frequency of APOE 2 in the schizophrenic patients was significantly lower than that in the controls. These findings are in agreement with only a few reports on the APOE genotypes in patients with schizophrenia (20,21) and stand in contrast to most other reports (13)(14)(15)(16)(17)(18)(19). Although the basis for this discrepancy is unclear, there are several possible explanations for this discrepancy.…”

Section: Discussionsupporting

confidence: 89%

Apolipoprotein E Genotype in Korean Schizophrenic Patients

et al. 2001

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The apolipoprotein E (APOE) 4 allele is a known risk factor for the development of Alzheimer' s disease, however, an association of the APOE genotype with schizophrenia is controversial. We investigated the association in 60 Korean schizophrenic patients and 60 healthy controls. APOE genotypes were identified by reverse hybridization-based line probe assay. There were significant differences in the distribution of APOE genotypes between schizophrenic patients and controls. APOE 2 and 3 allele frequencies in schizophrenic patients were significantly different from those in controls. Our results suggest that APOE alleles seem to be operative in the pathogenesis of schizophrenic disorders.

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Section: Discussionsupporting

confidence: 89%

Apolipoprotein E Genotype in Korean Schizophrenic Patients

et al. 2001

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“…However, subsequent studies in other populations have failed to replicate this finding. [8][9][10][11][12][13][14][15][16] Apart from these controversial results, it is interesting to note that some of the studies that found no association between APOE variants and the disease, did find an association with clinical variables such as age at onset 10,17 and scores for psychotic symptoms. 18,19 To further ascertain the possible association between the APOE variant and schizophrenia, and to determine whether the ⑀4 allele may modulate the clinical variables of patients, we have addressed this issue in a large sample of schizophrenic in-patients.…”

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confidence: 99%

“…However, several case-control association studies have found no association between the APOE genotype and schizophrenia. [8][9][10][11][12][13][14][15] The inconsistency in these data may be due to several factors; the samples may be too small, there may be problems of sample stratification, the cases and controls may not be correctly matched, and there may be ethnic differences.…”

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confidence: 99%

Schizophrenic women with the APOE ε4 allele have a worse prognosis than those without it

et al. 2001

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The ⑀4 allele of APOE is generally accepted to be a risk factor in Alzheimer's disease and it has been related to other neuropsychiatric disorders, including schizophrenia. The results of several case-control studies have been inconclusive. To shed more light on this issue we carried out an association study that compared the APOE common variant in a group of 365 schizophrenia patients and 584 controls. We found no differences in the genotype distributions and allele frequencies of patients and controls. In the group of patients, we also analysed the possible influence of the ⑀4 allele in the clinical variables. The most important findings are that the age at onset (AAO) of ⑀4+ schizophrenic women, those that have one or two ⑀4 alleles, is 4 years earlier than that of ⑀4− women and their risk of suffering a negative syndrome subtype is four times greater. This was not found in schizophrenic men. Our results show that the APOE variant is not a risk factor for developing schizophrenia but that it may modulate its phenotypic expression in a sex-dependent manner. Molecular Psychiatry (2001) 6, 307-310.

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“…In regard to schizophrenia, an initial early report suggesting a positive association between the presence of the ApoE e4 allele and schizophrenia (Harrington et al, 1995) has been refuted by more recent studies showing no association (Arnold et al, 1997;Jonsson et al, 1996;Joober et al, 1996;Kimura et al, 1997;Powchik et al, 1997;Town et al, 1997;Zhu et al, 1996). Some of these studies have also looked at age of onset, with two reports (Kimura et al, 1997;Zhu et al, 1996) showing no association between carriers of the ApoE e4 allele and age of onset and one report (Arnold et al, 1997) showing ApoE ~4 carriers to have an earlier onset.…”

Section: Guest Editorials Apolipoprotein E and Functional Illness In mentioning

confidence: 99%

“…Some of these studies have also looked at age of onset, with two reports (Kimura et al, 1997;Zhu et al, 1996) showing no association between carriers of the ApoE e4 allele and age of onset and one report (Arnold et al, 1997) showing ApoE ~4 carriers to have an earlier onset. In keeping with this finding, one study (Howard et al, 1995) of patients with late-onset (over the age of 60 years) schizophrenia showed a low frequency of the ApoE ~4 allele compared with published data in controls.…”

Section: Guest Editorials Apolipoprotein E and Functional Illness In mentioning

confidence: 99%

Apolipoprotein E and Functional Illness in the Elderly

Holmes

1998

Int. Psychogeriatr.

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Following on from the hypothesis of a role for the ApoE ε4 and ε2 alleles as risk and protective factors, respectively, for late-onset Alzheimer's disease (AD) came inevitable questions regarding other psychiatric conditions of late onset including depressive illness and schizophrenia. Is ApoE ε4 a risk factor in these diseases and do carriers have an earlier age of onset? Does ApoE ε2 have a protective role, with carriers of this allele having a later age of onset?

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Apolipoprotein E genotype distribution in schizophrenia

Cited by 24 publications

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Apolipoprotein E Genotype in Korean Schizophrenic Patients

Apolipoprotein E Genotype in Korean Schizophrenic Patients

Schizophrenic women with the APOE ε4 allele have a worse prognosis than those without it

Apolipoprotein E and Functional Illness in the Elderly

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