Apolipoprotein E Genotype in Korean Schizophrenic Patients

Lee, Mi Kyung; Park, Ae Ja; Nam, Bum Yoo; Min, Kyung Joon; Kee, Baik Seok; Park, Doo Byung

doi:10.3346/jkms.2001.16.6.781

Cited by 11 publications

(9 citation statements)

References 24 publications

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“…However, no such association was found in African-Americans, suggesting a definite role of race/ethnicity. Contrary to our findings, studies carried out on Korean [ 56 ] and Kuwaiti populations [ 37 ] showed a significant protective effect of APOE ε2 against the development of schizophrenia. Kimura et al .…”

Section: Discussioncontrasting

confidence: 99%

“…Some studies reported higher frequency of APOE ε2 in Parkinson's disease as compared to controls [ 62 ]. On the other hand, the possession of APOE ε2 has been associated with late-onset Alzheimer's disease, longevity in Down's syndrome, protection against the development of dementia, and protection against early-onset schizophrenia [ 33 , 37 , 56 , 63 , 64 ]. The mechanism by which APOE participates in the different pathogenic processes remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

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Basic research Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis

Al-Asmary

Kadasah

Arfin

et al. 2015

aoms

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IntroductionApolipoprotein E (APOE) genotypes influence the phenotype of several neurodegenerative disorders including Alzheimer's and Parkinson disease and may affect schizophrenia pathogenesis. This study was undertaken to determine the association between APOE gene polymorphisms and schizophrenia in the Saudi population.Material and methodsAPOE allele and genotype frequencies were studied in 380 Saudi subjects including schizophrenia patients and matched controls using polymerase chain reaction (PCR) and reverse-hybridization techniques.ResultsThe frequencies of the APOE allele ε2 and genotypes ε2/ε3 and ε2/ε4 were significantly higher in the schizophrenia patients as compared to controls, suggesting that the ε2 allele and its heterozygous genotypes may increase the susceptibility to schizophrenia. In contrast, the frequencies of the ε3 allele and ε3/ε3 genotype were lower in patients as compared to controls, suggesting a protective effect of APOE ε3 for schizophrenia. This study indicated that APOE ε4 was differentially associated with schizophrenia depending on the symptoms as the frequency of the ε4 allele was significantly higher in schizophrenia patients with positive symptoms. By contrast, no significant association between APOE ε4 and schizophrenia patients with negative symptoms was observed. Genotypes ε2/ε2 and ε4/ε4 were absent in patients and controls. Moreover, the age of onset was significantly lower in patients with the APOE ε2/ε3 genotype. There was no significant difference in the frequencies of APOE alleles and genotypes between male and female schizophrenia patients.ConclusionsThe results of this study clearly show that APOE alleles and genotypes are associated with risk of developing schizophrenia and early age of onset in Saudis.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Basic research Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis

Al-Asmary

Kadasah

Arfin

et al. 2015

aoms

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“…While some studies have reported that the frequency of APOE4 alleles was increased in patients with schizophrenia [19][20][21] , some others, in other populations, did not specifically indicate APOE as a specific risk factor for schizophrenia but rather suggested that specific allelic patterns in the disease could influence its clinical phenotype, including pattern of disease [22] , response to antipsychotic medication [23,24] , age at onset of disease [24][25][26] and odor identification [27] . In a meta-analysis of published data from 17 population-based case-control studies (6 Asian, 11 Caucasian) [28] , it was suggested that APOE4 type does not play a major role in risk of schizophrenia in Caucasian populations.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E Polymorphism and Clinical Disease Phenotypes in Arab Patients with Schizophrenia

Akanji¹,

Ohaeri²,

Al-Shammri³

et al. 2009

Neuropsychobiology

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Background: Apolipoprotein E (APOE) is polymorphic, and may be involved in the pathogenesis and clinical expression of schizophrenia. This study aimed to investigate the frequency of specific APOE genotypes and alleles in a schizophrenic Arab population and evaluate the association of specific APOE types with clinical phenotypes of the disease. Subjects and Methods: Two age-matched groups of subjects were studied: (1) healthy controls, n = 165; (2) patients with schizophrenia (SZ), n = 207. Each subject was evaluated for age and mode of onset of disease, family history of psychosis, disease severity and outcome over the years of illness. APOE genotyping was performed by a validated PCR-RFLP technique. Results and Discussion: Genotype E3E2 and allele E2 were less frequent in the patients with schizophrenia (p = 0.04), and both APOE types tended to be more common in male than female schizophrenic patients (p = 0.08). Schizophrenic patients with a positive family history of psychosis had lower frequencies of genotype E3E2 and allele E2 (both p = 0.04). Genotype E3E4 and allele E4 were least common in patients with an age at onset of disease >31 years (OR: 5.5, 95% CI: 1.1–27.4), particularly in males. Conclusion: APOE genetic polymorphism potentially influences susceptibility to schizophrenia and may be associated with aspects of its phenotypic expression, particularly gender, age of onset and family history of psychotic illness. This relationship of APOE with schizophrenia is likely to be race- and gender-specific.

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“…Saiz PA et al (2002) results showed that variation in the APOE gene expression indicate insignificant relationship with the development of schizophrenia in a Spanish population (9). By comparison, allelic variations of APOE gene seem to be momentous in pathogenesis of schizophrenic disorders in the Korean population (10). Schurhoff F et al (2003) observed a possible association between male schizophrenic patients and the APOE epsilon 2, epsilon 3 genotype in the French population (11).…”

Section: Introductionmentioning

confidence: 98%

APOE and CPT1-A Promoter Methylation and Expression Profiles in Patients with Schizophrenia

2014

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Background: Apo-lipoprotein E (APOE) and Carnitine palmitoyltransferase1-A (CPT1-A) genes are well known to be involved in the pathophysiology of psychiatric disorders such as schizophrenia but regarding their CPG island methylation status data is sparse. Objectives: The aims of the current study were to highlight the effect of the promoter "hypermethylation" in the development of SCZ. Patients and Methods: Genomic DNA was extracted from peripheral blood of 80 patients with schizophrenia and 71 healthy controls. The Methylation pattern was studied using Methylation-Specific PCR. RNA expression analysis was performed on extracted RNA from blood samples of patients suffering from schizophrenia (n = 17) and healthy controls (n = 17). Results: Frequency of the APOE and CPT1-A methylation show insignificant relationship between cases and controls. Estimates of relative gene expression revealed no significant statistical association of the APOE and CPT1-A genes between schizophrenic patients and healthy controls. Conclusions: This is the first evidence regarding APOE and CPT1-A gene methylation and their expression profile related to risk of schizophrenia which indicate no significant association between the APOE and CPT1-A gene methylation and development of schizophrenia.

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Apolipoprotein E Genotype in Korean Schizophrenic Patients

Cited by 11 publications

References 24 publications

Basic research Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis

Basic research Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis

Apolipoprotein E Polymorphism and Clinical Disease Phenotypes in Arab Patients with Schizophrenia

APOE and CPT1-A Promoter Methylation and Expression Profiles in Patients with Schizophrenia

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