Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease

Chaudhary, Rajesh; Likidlilid, Atip; Peerapatdit, Thavatchai; Tresukosol, Damras; Srisuma, Sorachai; Ratanamaneechat, S.; Sriratanasathavorn, Charn

doi:10.1186/1475-2840-11-36

Cited by 114 publications

(110 citation statements)

References 54 publications

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“…The present study demonstrates higher blood pressure in children with obesity and AN than in children with normal weight. The greatest difference was found in systolic blood pressure, in accordance with the study by Dong B et al on children and adolescents in China (40), by Chiolero A. on children of the Republic of Seychelles in Africa (41), by Moser on Brazilian children (42), and by Hoog who studied the association between blood pressure and BMI in children from different ethnic groups (43).…”

Section: Discussionsupporting

confidence: 87%

Acantosis nigricans is associated with risk factors related to cardiovascular disease in Mexican children with obesity

Martínez-Rojano

Pizano-Zárate²,

Sánchez-Jiménez³

et al. 2016

Nutr Hosp

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ResumenIntroducción: la mayor prevalencia de obesidad en la población infantil mexicana durante la última década incrementa el riesgo de presentar trastornos metabólicos y enfermedades cardiovasculares a edades cada vez más tempranas. Objetivo: determinar la asociación entre Acantosis nigricans (AN) con dislipidemia, hipertensión arterial, índice de masa corporal (IMC) y conductas alimentarias de riesgo en niños con sobrepeso y obesidad. Pacientes y métodos: estudio transversal analítico realizado en dos escuelas públicas de la zona metropolitana de la ciudad de México donde participaron 300 niños, de ambos sexos, obteniéndose información de los antecedentes heredofamiliares y perinatales. Con la exploración física se valoró la presencia o ausencia de AN y presión sanguínea. Se pesó y midió a los escolares, se calculó el IMC y se estimó su puntaje Z. Se cuantifi có la concentración sérica de glucosa, colesterol, triglicéridos y perfi l de lipoproteínas. Resultados: la prevalencia de AN fue 41,7%, al determinar la asociación entre la AN y los factores de riesgo cardiovascular, se identifi có una asociación con el IMC (rS 0.432; p < 0.0001), entre las cifras de presión arterial sistólica y diastólica por encima del percentil 90 (rS 0.231; p < 0.0001) y (rS 0.128; p = 0,026) respectivamente, la hipertrigliceridemia (rS 0.156; p = 0.007), las bajas concentraciones de colesterol de lipoproteínas de alta densidad (cHDL) (rS -0,160; p = 0,006), así como la existencia de los trastornos de la conducta alimenticia; haber realizado dietas p = 0.004, ha perdido el control de lo que come p = 0,023 y cuando el porcentaje de grasa corporal fue superior al percentil 90, χ 2 = 35.1; p = 0.0001, no se observó asociación con la concentración sérica de glucosa (rS -0.018; p = 0,759). En el análisis de regresión logística se observó que la presencia de AN mostró una asociación con las menores concentraciones de cHDL (RM: 1.726; p = 0,041) y con el porcentaje de grasa corporal (> 48%) (RM: 3.591; p = 0,001). Conclusión: se observó una alta prevalencia de AN en niños con sobrepeso u obesidad y su asociación con factores de riesgo cardiovascular: puntaje Z del IMC, dislipidemia y las cifras tensionales elevadas. AbstractIntroduction: The prevalence of obesity in Mexican children has increased during the last decade, as has the risk of early onset metabolic disorders and cardiovascular disease. Objective: To determine the association of Acantosis nigricans (AN) with dyslipidemia, high blood pressure, body mass index (BMI), and risk factors related to eating behavior in overweight and obese children. Patients and methods: This transverse analytical study, conducted in two Mexico City primary schools, included 300 boys and girls. Information was gathered on hereditary and perinatal background. A physical examination provided data on the presence/absence of AN, blood pressure, weight and height. The BMI and Z-score were calculated. The serum concentration of glucose, cholesterol and triglycerides was quantifi ed and the lipoprotein profi l...

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Section: Discussionsupporting

confidence: 87%

Acantosis nigricans is associated with risk factors related to cardiovascular disease in Mexican children with obesity

Martínez-Rojano

Pizano-Zárate²,

Sánchez-Jiménez³

et al. 2016

Nutr Hosp

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“…[2][3][4][5] The combination of these lipoprotein abnormalities, termed atherogenic dyslipidemia (AD), is highly prevalent in patients with diabetes mellitus or metabolic syndrome, and, in addition to high LDL-C, contributes independently to cardiovascular risk. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] Treatment with fibrates may reduce cardiovascular risk in patients with AD associated with metabolic syndrome and type 2 diabetes mellitus. 20 However, in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study, the use of fenofibrate and simvastatin did not reduce the rates of cardiovascular events compared with simvastatin alone.…”

mentioning

confidence: 99%

Atherogenic Dyslipidemia and Residual Cardiovascular Risk in Statin-Treated Patients

Gaia

Labreuche

Bruckert

et al. 2014

Stroke

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Background and Purpose-Treatment with statins reduces the rate of cardiovascular events in high-risk patients, but residual risk persists. At least part of that risk may be attributable to atherogenic dyslipidemia characterized by low highdensity lipoprotein cholesterol (≤40 mg/dL) and high triglycerides (triglycerides ≥150 mg/dL). Methods-We studied subjects with stroke or transient ischemic attack in the Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin With Terutroban in Patients With a History of Ischemic Stroke or Transient Ischemic Attack (PERFORM; n=19 100) and Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL; n=4731) trials who were treated with a statin and who had high-density lipoprotein cholesterol and triglycerides measurements 3 months after randomization (n=10 498 and 2900, respectively). The primary outcome measure for this exploratory analysis was the occurrence of major cardiovascular events (nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death). We also performed a time-varying analysis to account for all available high-density lipoprotein cholesterol and triglyceride measurements. Results-A total of 10% of subjects in PERFORM and 9% in SPARCL had atherogenic dyslipidemia after ≥3 months on start statin therapy. After a follow-up of 2.3 years (PERFORM) and 4.9 years (SPARCL), a major cardiovascular event occurred in 1123 and 485 patients in the 2 trials, respectively. The risk of major cardiovascular events was higher in subjects with versus those without atherogenic dyslipidemia in both PERFORM (hazard ratio, 1.36; 95% confidence interval, 1.14-1.63) and SPARCL (hazard ratio, 1.40; 95% confidence interval, 1.06-1.85). The association was attenuated after multivariable adjustment (hazard ratio, 1.23; 95% confidence interval, 1.03-1.48 in PERFORM and hazard ratio, 1.24; 95% confidence interval, 0.93-1.65 in SPARCL). Time-varying analysis confirmed these findings. Conclusions-The presence of atherogenic dyslipidemia was associated with higher residual cardiovascular risk in PERFORM and SPARCL subjects with stroke or transient ischemic attack receiving statin therapy. Specific therapeutic interventions should now be trialed to address this residual risk.

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“…A 2-es típusú cukorbetegség kialakulásával is összefüggésbe hozható [42], valamint megnöveli pél-dául ökölvívók esetében az agysérülés fellépésének kockázatát [43].…”

Section: Apoe4unclassified

Connections between apolipoprotein E genotypes and the development of cardiovascular diseases

Végh¹,

Langmár

Szerző³

et al. 2012

Orvosi Hetilap

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A vérplazma emelkedett lipidszintje a cardiovascularis betegségek kialakulásának egyik legfőbb kockázati tényezője, amelyet elsődleges halálokként tartanak számon. Az apolipoprotein E a lipidek szállításában vesz részt a vérben, ezért polimorfi zmusai befolyásolják a plazma lipidösszetételét. Az apolipoprotein E génjének három leggyakoribb alléljai az e2, az e3 és az e4. A két nem vad típusú allél, az e2 és e4 közül az utóbbi számos vizsgálat eredménye szerint szerepet játszik a szív-ér rendszeri betegségek, valamint az Alzheimer-kór kialakulásában. Az e2/e2 homozigóta genotípust a 3-as típusú hyperlipoproteinaemia egyik előidézőjeként említik egyes tanulmányok. Mivel az apolipoprotein E nemcsak a lipidanyagcsere útján, hanem más biokémiai útvonalakon is befolyásolhatja a cardiovascularis betegségek manifesztációját, így kiemelkedő fontosságú lehet ezen anyagcsereutak molekuláris hátterének felderítése. Orv. Hetil., 2012Hetil., , 153, 2070Hetil., -2076 Kulcsszavak: apolipoprotein E, cardiovascularis betegség, lipidanyagcsere, apoE-polimorfi zmus Connections between apolipoprotein E genotypes and the development of cardiovascular diseasesElevated plasma lipid level is one of the main risk factors for cardiovascular diseases, which are considered to be pimary causes of death. Apolipoprotein E plays a part in the lipid transport in the blood, thus polimophisms of that affect the lipid composition of the plasma. The three most common alleles of apolipoprotein E are e2, e3, e4. Out of the two non-wild type alleles, the e2 and e4, the latter was shown to play a role in the development of cardiovascular diseases and Alzheimer's disease. Some studies mention the e2/e2 homozygote genotype as one of the causes of hyperlipoproteinemia type III. Besides lipid metabolism, apolipoprotein E also infl uences the manifestation of cardiovascular diseases through other biochemical pathways, therefore it is essential to explore the molecular background of these metabolic pathways. Orv. Hetil., 2012Hetil., , 153, 2070Hetil., -2076 Keywords: apolipoprotein E, cardiovascular disease, lipid metabolism, apoE polymorphism (Beérkezett: 2012. október 17.; elfogadva: 2012. november 11.) Rövidítések apoB100 = apolipoprotein B100; apoE = apolipoprotein E; HDL = magas denzitású lipopro tein; IDL = közepes denzitású lipoprotein; LDL = alacsony denzitású lipoprotein; LRP = lipoproteinreceptorhoz kötődő fehérje; SNP = egypontos nukleotidpolimorfi zmus; VLDL = nagyon alacsony denzitású lipoprotein; III HLP = 3-as típusú hyperlipoproteinaemiaAz apolipoprotein E (apoE) szerepe a lipidanyagcseré-ben és a koleszterin transzportjában jól ismert. A vér-ben keringő zsírok és koleszterin felhalmozódása köz-tudottan az erek és a szív károsodásához, majd később nagyon súlyos, kóros állapotokhoz, végül sok esetben halálhoz vezetnek.

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Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease

Cited by 114 publications

References 54 publications

Acantosis nigricans is associated with risk factors related to cardiovascular disease in Mexican children with obesity

Acantosis nigricans is associated with risk factors related to cardiovascular disease in Mexican children with obesity

Atherogenic Dyslipidemia and Residual Cardiovascular Risk in Statin-Treated Patients

Connections between apolipoprotein E genotypes and the development of cardiovascular diseases

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