Connections between apolipoprotein E genotypes and the development of cardiovascular diseases

Végh, Csaba; Langmár, Zoltán; Szerző, Melinda; Ágota, Annamária; Marosi, Krisztina; Szepes, Zoltán; Nagy, Zsolt B.

doi:10.1556/oh.2012.29508

Cited by 5 publications

(2 citation statements)

References 56 publications

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“…In our study, we also observed that APOEε 4 carrier was a significant risk factor for High-TC and High-LDLC, indicating that genetic factors have a direct effect on cholesterol metabolism. Recent studies on the association between APOE polymorphism and risk of cardiovascular disease had reached similar conclusions [ 46 – 49 ], and more evidence could be found in studies on APOE polymorphism and lipid levels [ 50 – 53 ]. On the question of potential interactions between APOE genotype and selenium level for the development of dyslipidemia, animal studies demonstrated that selenium supplementation was responsible for down regulation of apoB expression during hypercholesterolemia [ 54 , 55 ], and could increase the LDL-receptor activity [ 56 , 57 ].…”

Section: Discussionmentioning

confidence: 89%

Selenium Level and Dyslipidemia in Rural Elderly Chinese

Gao

Unverzagt

et al. 2015

PLoS ONE

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ObjectiveHigher selenium level has been hypothesized to have the potential to reduce the risk of cardiovascular diseases including dyslipidemia. However, results from previous studies are inconsistent. This study aims to determine the association between selenium level and dyslipidemia in elderly Chinese with relatively low selenium status.MethodsA cross-sectional study of 1859 participants aged 65 or older from four rural counties in China was conducted. Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDLC) and low-density lipoprotein-cholesterol (LDLC), nail selenium concentration and APOE genotype were measured in all subjects. The four types of dyslipidemia were defined as >5.17mmol/L for High-TC, >1.69 mmol/L for High-TG, >3.36 mmol/L for High-LDLC, and <1.04 mmol/L for Low-HDLC according to Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. Logistic models adjusting for age, gender, APOE genotype, body mass index, alcohol consumption, smoking, physical activity, medication use for cardiovascular diseases were used to examine the relationship between selenium levels and the risk of dyslipidemia.ResultsMean nail selenium concentration was 0.465μg/gin this sample. Rates for High-TC, High-LDLC, High-TG, Low-HDLC were 18.13%, 13.23%, 12.21% and 32.76% respectively. Results from logistic models indicated that higher selenium levels were significantly associated with higher risk of High-TC, High-LDLC and lower risk of Low-HDLC adjusting for covariates (p < 0.0001). Compared with the lowest selenium quartile group, participants in selenium quartile groups 2, 3 and 4 had significantly higher rates of High-TC, High-LDLC, High-TG, and lower rate of Low-HDLC adjusting for covariates. No significant association was observed between selenium level and the risk of High-TG. APOEε4 carriers had higher rates of High-TC and High-LDLC. There was no interaction between selenium level and APOE with the rates of dyslipidemia.ConclusionsOur results suggest long-term selenium exposure level may be associated with the risk of dyslipidemia in elderly population. Future studies are needed to examine the underlying mechanism of the association.

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Section: Discussionmentioning

confidence: 89%

Selenium Level and Dyslipidemia in Rural Elderly Chinese

Gao

Unverzagt

et al. 2015

PLoS ONE

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“…It is confirmed in some meta-analysis that carriers of ε4 allele have increased risk for coronary heart disease in Chinese [ 28 , 29 ]. And it was showed that the APOE variants result in a 2-fold or greater increased risk for coronary artery disease, myocardial infarction, and ventricular fibrillation [ 30 ]. Researches showed that APOE ε4 allele was associated with BMI, hypertension, and diabetes [ 31 – 33 ].…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population

Zhao

Chen

et al. 2017

Bioscience Reports

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Ischemic stroke (IS), the leading neurology cause of death and disability worldwide, is influenced by gene polymorphisms. To explore the association between IS and Apolipoprotein E (APOE) gene polymorphisms, a case–control study containing 513 IS patients and 514 controls without IS was conducted in a Northwest China Han population. MassARRAY iPLEX system was applied to determine the APOE polymorphisms according to the alleles of two single nucleotide polymorphisms (SNPs) of APOE, rs429358, and rs7412. The results showed that rs429358 and rs7412 were in Hardy–Weinberg equilibrium (HWE) in both cases and controls groups. APOE ε4 allele, ε4/ε4 genotype, and ε4-containing genotypes were associated with IS. According to the results of Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification system, APOE ε2 allele, ε4 allele, and ε4/ε4 genotype were associated with large artery atherosclerosis IS subtypes. In addition, the results also indicated that the ε4 allele related to undetermined IS and ε4/ε4 genotype was related to small vessel disease IS. Compared with subjects with non-ε4-containing genotypes, the total cholesterol (TC) and low-density lipoprotein (LDL) level in blood and the proportion of cardiopath history were higher in all subjects with ε4-containing genotypes. Besides, the triacylglycerides (TG) level in blood was higher in controls with ε4-containing genotypes. In conclusion, in a Northwest China Han population, APOE ε4 allele was associated with blood lipid level. The TC and LDL levels were the independent risk factors for IS. APOE was a risk gene for IS, but not independent, especially for large artery atherosclerosis IS.

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