Apolipoprotein E alleles in childhood‐onset schizophrenia

A systematic review of the effect of genes mediating neurodevelopment and neurotransmission on brain morphology: Focus on schizophrenia

“…117 However, no such association between the e4 allele (n = 14) and hippocampal (t = 0.23, df = 33, P < 0.82) volumes (t = 0.27, df = 33, P < 0.79) was found in patients with childhood-onset schizophrenia (COS) (N = 40). 118 (xvii). Vaccinia related kinase2 (VRK2)…”

Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population

“…Our results are in accordance with most previous studies that showed no relationship between APOE polymorphism and incidence of schizophrenia (Chen et al, 1999;Fernandez et al, 1999;Kimura et al, 2000), although Harrington et al (1995) and Liu et al (2003) showed a large excess of ε4 in the schizophrenia population compared to controls. However, APOE ε3 allele showed tendency toward a negative association with particular subtypes of schizophrenia (p = .01221).…”

“…Clinical similarities between the chronic schizophrenic patients and those with AD (cognitive impairement, psychotic symptoms, and changes of behavioral and affective patterns) have led to numerous studies on the role of APOE genotypes in schizophrenia. The association between APOE genotype and schizophrenia was first reported by Harrington et al (1995), and subsequent studies revealed conflicting findings (Arnold et al, 1997;Chen et al, 1999;Durany, Riederer, & Cruz-Sanchez, 2000;Fernandez et al, 1999;Fisman et al, 2001;Hong et al, 2000;Kampman et al, 2004;Kimura et al, 2000;Liu et al, 2003;McGuffin et al, 2003;Pickar et al, 1997;Saiz et al, 2002). APOE Genotyping in Serbian Population 503 Early age of onset in schizophrenia has been associated with an excess of ε4 allele in two different samples (Arnold et al, 1997), but in the study by the frequency of ε4 was lower in the early onset group.…”

Apolipoprotein E-ε4 allele predicts escalation of psychotic symptoms in late adulthood

“…Studies were included if they used a case-control design, reported allele frequencies for APOE-ε4 in subjects with schizophrenia, and reported the mean age of the schizophrenia group. We limited the analysis to studies of adults, thus excluding one study in which the mean age of cases was <18 (Fernandez et al, 1999).…”