Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population

Kecmanović, M; Dobričić, Valerija; Dimitrijević, Rajna; Keckarević, Dušan; Savić‐Pavićević, Dušanka; Keckarević-Marković, Milica; Ivković, Maja; Romac, Stanka

doi:10.3109/00207451003765956

Cited by 9 publications

(6 citation statements)

References 30 publications

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“…The results of this study also showed significantly lower frequencies of allele ε3 and genotype ε3/ε3 among Saudi schizophrenic patients as compared to healthy controls ( Table I ), suggesting that the ε3 allele confers protection against schizophrenia in the Saudi population. Our findings are in agreement with several published studies on other populations including Chinese [ 65 ], Finnish [ 66 ] and Serbian [ 38 ], in which decreased frequencies of genotype ε3/ε3 and allele ε3 were observed in schizophrenia patients compared to controls, and the effect was independent of sex and age of onset of illness. Kampman et al .…”

Section: Discussionsupporting

confidence: 93%

“…The results of a recent study by Kecmanovič et al . [ 38 ] further strengthened the reports that the ε3 allele could serve as a protective factor against symptoms more abundant in undifferentiated types of schizophrenia. In contradiction to these, some reports on schizophrenic patients from Taiwan [ 34 ], Korea [ 56 ] and Mexico [ 36 ] stated that the development of schizophrenia in these populations is associated with higher frequency of allele ε3.…”

Section: Discussionmentioning

confidence: 63%

“…in 1995 [ 28 ]. However, subsequent studies on APOE genotype distribution in schizophrenia have produced conflicting findings [ 29 – 38 ].…”

Section: Introductionmentioning

confidence: 99%

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Basic research Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis

Al-Asmary

Kadasah

Arfin

et al. 2015

aoms

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IntroductionApolipoprotein E (APOE) genotypes influence the phenotype of several neurodegenerative disorders including Alzheimer's and Parkinson disease and may affect schizophrenia pathogenesis. This study was undertaken to determine the association between APOE gene polymorphisms and schizophrenia in the Saudi population.Material and methodsAPOE allele and genotype frequencies were studied in 380 Saudi subjects including schizophrenia patients and matched controls using polymerase chain reaction (PCR) and reverse-hybridization techniques.ResultsThe frequencies of the APOE allele ε2 and genotypes ε2/ε3 and ε2/ε4 were significantly higher in the schizophrenia patients as compared to controls, suggesting that the ε2 allele and its heterozygous genotypes may increase the susceptibility to schizophrenia. In contrast, the frequencies of the ε3 allele and ε3/ε3 genotype were lower in patients as compared to controls, suggesting a protective effect of APOE ε3 for schizophrenia. This study indicated that APOE ε4 was differentially associated with schizophrenia depending on the symptoms as the frequency of the ε4 allele was significantly higher in schizophrenia patients with positive symptoms. By contrast, no significant association between APOE ε4 and schizophrenia patients with negative symptoms was observed. Genotypes ε2/ε2 and ε4/ε4 were absent in patients and controls. Moreover, the age of onset was significantly lower in patients with the APOE ε2/ε3 genotype. There was no significant difference in the frequencies of APOE alleles and genotypes between male and female schizophrenia patients.ConclusionsThe results of this study clearly show that APOE alleles and genotypes are associated with risk of developing schizophrenia and early age of onset in Saudis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 63%

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Basic research Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis

Al-Asmary

Kadasah

Arfin

et al. 2015

aoms

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“…Moreover, a French association study and meta-analysis showed that only in a male sample, there was an association between schizophrenia and ApoE ε2ε3 genotype [ 60 ]. In addition, an association between undifferentiated type of schizophrenia and ApoE ε3/ε3 genotype was found in a Serbian population [ 61 ]. Both ApoE ε3 and ApoE -219G haplotypes increased the risk of schizophrenia in siblings [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia

Rao

Meng

et al. 2021

Ann Gen Psychiatry

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Background The apolipoprotein E (ApoE) gene polymorphisms are correlated with blood lipid levels and several neuropsychiatric symptoms. Therefore, this study aimed to examine whether the ApoE rs429358 affected the development and clinical symptoms of schizophrenia and to explore the relationship between apolipoproteins levels and clinical symptoms. Methods The ApoE rs429358 was genotyped using a case–control design. The Positive and Negative Syndrome Scale (PANSS) was employed to evaluate the psychopathology of all patients. Results A total of 637 patients with schizophrenia and 467 healthy controls were recruited. We found no significant differences in the genotype and allele distribution between the patient and control groups. A significant correlation between PANSS negative symptoms and ApoA1 levels (p = 0.048) or ApoB levels (p = 0.001) was found in patients with schizophrenia, which was also confirmed by linear regression analyses (p = 0.048 vs. p = 0.001). Interestingly, only in the T homozygote group, ApoA1 and ApoB levels were predictors of the PANSS negative symptom score (p = 0.008 vs. p = 0.012), while in the C allele carrier group, no correlation was observed. Conclusions This study found that the levels of ApoA1 and ApoB were negatively associated with negative symptoms of patients with schizophrenia. Furthermore, the association between ApoA1 or ApoB levels and psychopathology of schizophrenia was regulated by ApoE rs429358.

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“…Another group identified a link with positive symptoms (Al-Asmary et al, 2015). More commonly, findings linking APOE-ε4 and diagnostic subtypes have been null (Akanji et al, 2009;Arnold et al, 1997;Durany et al, 2000;Jönsson et al, 1996;Kecmanović et al, 2010), although this literature is likely limited by the poor reliability of diagnostic subtypes (Tandon et al, 2013). However, no prior study has examined whether APOE-ε4 is associated with symptom trajectories as participants age.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein E-ε4 allele predicts escalation of psychotic symptoms in late adulthood

Jonas

Clouston

et al. 2019

Schizophrenia Research

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Background: Research on a putative link between apolipoprotein-ε4 allele (APOE-ε4) and schizophrenia has been inconclusive. However, prior studies have not investigated the association between APOE-ε4 and symptom trajectories, nor has the existing literature taken into account the potentially moderating effect of age in genetic association studies. Methods: The association between APOE-ε4 and four symptom dimensions was investigated in a longitudinal study of 116 individuals with schizophrenia initially assessed during their first admission for psychosis and evaluated five times over the following 20 years. A meta-analysis

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Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population

Cited by 9 publications

References 30 publications

Basic research Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis

Basic research Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis

Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia

Apolipoprotein E-ε4 allele predicts escalation of psychotic symptoms in late adulthood

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