Apolipoprotein B as an independent predictor of arterial stiffness in systemic lupus erythematosus patients

Abstract

Aim: To determine the relationship of apolipoprotein B (Apo-B) and arterial stiffness determined by brachialankle pulse wave velocity (baPWV) in systemic lupus erythematosus (SLE) subjects.Methods: Eighty-seven Thai SLE subjects with inactive disease activity were studied. Fasting blood was collected for creatinine, glucose, lipid profiles, Apo-B and Apo-A1. Pearson correlation and stepwise-linear regression were used for the analysis.Results: The mean age of the subjects was 36.69 AE 10.85 years; 6.90% of them had stage 3 or more severe chronic kidney disease, 49.40% took anti-hypertensive drugs and 4.60% had abnormal glucose metabolism. The mean value for baPWV was 1332 AE 274.12 cm/s. Thirty-six percent of the subjects had increased arterial stiffness with mean Apo-B levels of 1.05 AE 0.31 g/L compared to 0.94 AE 0.24 in normal arterial stiffness. There were correlations of baPWV with age, systolic blood pressure (BP), diastolic BP and creatinine clearance. Apo-B tended to be associated with baPWV (P = 0.06) whereas low-density lipoprotein cholesterol did not (P = 0.2). By multiple regression analysis, systolic BP, age and Apo-B were the significant predictors of baPWV.Conclusion: Apo-B was independently associated with arterial stiffness in SLE subjects.

Patients With Systemic Lupus Erythematosus Show an Increased Arterial Stiffness That is Predicted by IgM Anti–β2‐Glycoprotein I and Small Dense High‐Density Lipoprotein Particles

“…This result is important, because the cardiovascular risk profile determined by the lipids in this population again appeared to underestimate the real atherogenic profile in SLE patients. We observed that the atherogenic Apo B-containing lipoproteins and the small dense HDL particles that have been previously described as being proinflammatory and proatherogenic in SLE patients were associated with a worse AIx (48,49).…”

“…We observed that the atherogenic Apo B-containing lipoproteins and the small dense HDL particles that have been previously described as being proinflammatory and proatherogenic in SLE patients were associated with a worse AIx (48,49). This result is important, because the cardiovascular risk profile determined by the lipids in this population again appeared to underestimate the real atherogenic profile in SLE patients.…”

High-density lipopoprotein antioxidant capacity, subpopulation distribution and paraoxonase-1 activity in patients with systemic lupus erythematosus

“…Previously, increased ApoB level was found to be associated to larger plaque burden and larger presence of non-calcified plaques in patients with ischemic heart disease [ 28 ]. In a previous study on 87 SLE patients with inactive disease, ApoB concentration was shown to be independently associated with pulse wave velocity [ 29 ]. Deposition of ApoB within the arterial wall, which is one of the initiating steps of atherosclerosis, was detected in coronary plaques by fluorescent microscopy [ 30 ].…”

Metabolomics in juvenile-onset SLE: identifying new biomarkers to predict cardiovascular risk

“…Reduced ApoA1 and reduced HDL concentration have been reported previously in JSLE patients compared with healthy donors [43] and increased Apo-B was associated with arterial stiffness in adult SLE patients [44].…”