Apolipoprotein AI-CIII gene polymorphisms in Japanese myocardial infarction survivors

Satoh, Juichi; Hattori, Naoko; Onuki, Mieko; Yamakawa, Katsutoshi; Fujiwara, Hideomi; Amamiya, Hiroshi; Nagaoka, H; Sakuma, Toru; Yamanouchi, Yasuko; Okafuji, Takaaki; Iwamura, Yukio; Tsuchiya, Shigeru; Fukutomi, Hisayuki; Ohsuga, Toshiaki; Hamaguchi, Hideo

doi:10.1007/bf01876523

Cited by 5 publications

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“…The frequencies of the $2 and M2 alleles observed in this study are similar to those for 35 healthy Japanese reported by Rees et al (1986) as shown in Table 3. There were no differences in both the frequencies of the $2 and M2 alleles between Japanese myocardial infarction survivors and healthy subjects (Satoh et al, 1987). The presence of linkage disequilibrium between the $2 and M2 alleles has been reported in both the Caucasians and Japanese (Ferns and Galton, 1986;Rees et al, 1986).…”

Section: Discussionmentioning

confidence: 85%

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Apolipoprotein AI-CIII gene polymorphisms in a Japanese population

et al. 1986

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SummaryApolipoprotein (apo) CIII Sst-I genotypes and apo AI Msp-I genotypes were investigated in 82 unrelated healthy Japanese, using genomic hybridization analysis with a 2.2 kb fragment of the human apo AI gene. The frequencies of the $2 and M2 alleles were 0.34 and 0.40, respectively, and much higher than those in Caucasians. The alleles identified by the apo CIII Sst-I and apo AI Msp-I polymorphisms were observed to be in linkage disequilibrium (A=0.206+0.012, p<0.001). Three of the four possible haplotypes were identified: the frequencies of the haplotype were S1-M1=0.604, $2-M2=0.341, and S1-M2=0.055. The data indicate that Japanese are characterized by the common presence of the haplotype $2-M2 as compared with Caucasians and that the haplotypes identified by the apo CIII Sst-I and apo AI Msp-I polymorphisms are useful genetic markers for Japanese.

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Section: Discussionmentioning

confidence: 85%

“…Therefore the haplotypes identified by the apo CIII Sst-I and apo AI Msp-I polymorphisms are useful genetic markers for Japanese. Indeed the haplotypes have been effectively used for the genetic analysis of hypertriglyceridemia and myocardial infarction in Japanese (Rees et al, 1986;Satoh et aL, 1987).…”

Section: Discussionmentioning

confidence: 99%