Common Genetic Variants of Lipoprotein Lipase and Apolipoproteins AI–CIII That Relate to Coronary Artery Disease: A Study in Chinese and European Subjects

Zhang, Qiuping; Liu, Y.; Liu, B.W.; Fan, Ping; Cavanna, J.; Galton, D. J.

doi:10.1006/mgme.1998.2712

Cited by 20 publications

(15 citation statements)

References 22 publications

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“…Lille population composed of 495 men and 176 women living in the urban community of Lille (Dallongeville et al 2001) e Czech Slav population (Waterworth et al 2000) f Italian population recruited from five schools in the tenth district of Rome (Shoulders et al 1996) g Population living at 2,000 km Northwest of Toronto, Ontario (Hegele et al 1997) (Hegele et al 1995) b Population from the Rockefeler University Hospital or members of the university community (Dammerman et al 1993) c Control population from the Framingham cohort (Ordovas et al 1991) d ARIC population from four different US cities (Surguchov et al 1996) e EARS control population came from 11 European countries divided into four regions: Baltic, United kingdom; middle Europe and southern Europe (Waterworth et al 1999) f Europeans came from the European Union Biomedical Project comprising subjects with no personal or familial history of coronary heart disease and from Germany, Spain and Italy (Zhang et al 1998) g Broader population survey on cardiovascular risk factors h Population from Scotland was control men without coronary heart disease history (Rees et al 1983) i Utrecht are spouses of Dutch Caucasians FCHL recruited from the lipid clinic of the University Medical Centre Utrecht (Groenendijk et al 2001) j Italian population recruited from five schools in the tenth district of Rome (Shoulders et al 1996) k Population from London was healthy controls (Price et al 1989) markers (Dallongeville et al 2000). Furthermore, the G3238 allele was found to be associated with HTG in different populations, such as Caucasians (Dammerman et al 1993;Ordovas et al 1991;Shoulders et al 1996), Arabs (Tas 1989) and Japanese (Zeng et al 1995), and with elevated plasma apoCIII levels in healthy English (Shoulders et al 1991), Italian school children (Shoulders et al 1996) and Dutch Caucasians' spouses (Dallinga-Thie et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Population prevalence of APOE, APOC3 and PPAR-α mutations associated to hypertriglyceridemia in French Canadians

et al. 2004

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Hypertriglyceridemia (HTG) is known as a common metabolic disorder associated with increased production, decrease catabolism and/or decreased hepatic uptake of triglyceride (TG)-rich particles. We assessed, in the Que´bec City population, the allele frequency and haplotype distributions of mutations in genes related to HTG, such as the apolipoprotein E (APOE) (C112R and C158R), the apolipoprotein CIII (APOC3) (C-482T and C3238G) and the peroxisome proliferator-activated receptor alpha (PPARa) (L162V) genes. A total of 938 anonymous unlinked newborns from the metropolitan Que´bec City area have been genotyped. Allele frequencies observed in the Que´bec City population differed from known frequencies determined in other Caucasian populations. The cotransmitted allele distribution between the two-marker genotypes APOE/APOC3(C3238G) and APOC3(C-482T)/PPARa(L162V) presented a weak deviation from the assumption of genetic independence. Also, we observed a non-independent distribution of the T-482/G3238 allele combinations within the APOC3 gene, suggesting strong linkage disequilibrium between the C-482T and C3238G polymorphisms. Moreover, comparisons of allele frequencies observed in the population of Que´bec City to those obtained in other Caucasian populations suggested that the population of Que´bec City may be at a lower risk of developing HTG due to APOE, APOC3 and PPARa genetic variants. However, the strong linkage disequilibrium and the two-marker genotype distributions observed in the APOC3 gene suggest that these two variants may functionally interact in the Que´bec City population.

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Section: Discussionmentioning

confidence: 99%

Population prevalence of APOE, APOC3 and PPAR-α mutations associated to hypertriglyceridemia in French Canadians

et al. 2004

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“…The frequency of the +83 bp substitution in a healthy Caucasian population was lower (rare allele frequency: 0.04) than that at the À75 bp site [21]. However, some studies reported that patients with the base changes at À75 and/or +83 bp of the apoA-I gene have more severe CHD in both Caucasian and Chinese populations [21,22]. In those studies, base changes at À75 and +83 bp of the apoA-I gene were not associated with increased HDL-cholesterol levels.…”

Section: Introductionmentioning

confidence: 90%

Association of two apolipoprotein A-I gene MspI polymorphisms with lipid and blood pressure levels

Qing

Thomas

Tomlinson

2005

International Journal of Cardiology

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“…For the two polymorphisms of both ApoCIII and CETP genes, we estimated the coefficient of linkage disequilibrium D' (D/D max if D > 0) ± SD and P value for a two-marker combination using the 2LD program (Zhao et al 2000). Since allelic frequencies of LPL mutations resulting in a severe decrease in LPL activity were very low, we combined N291S, D9N, P207L, G188E and D250N polymorphisms to increase the power to detect an association (Ishimura-Oka et al 1992;Zhang et al 1998).…”

Section: Statisticsmentioning

confidence: 99%

The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension

et al. 2007

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Dyslipidemia and insulin resistance contribute to the endothelial cell dysfunction in hypertensive disorders of pregnancy (HDP) and increase the long-term risk of cardiovascular disease (CVD). The genes linking susceptibility to gestational hypertension (GH) and/or preeclampsia (PE) to the long-term risk of CVD are still unknown. We evaluated the potential association between 14 polymorphisms from six genes involved in lipid metabolism and insulin action and the risk of HDP: namely the lipoprotein lipase (LPL), hepatic lipase (LIPC), hormone sensitive lipase (LIPE), cholesteryl ester transfer protein (CETP), ApoCIII and ApoE gene polymorphisms. Overall, 169 women with HDP [proteinuria (PE) and gestational hypertension without proteinuria (GH)] and 169 controls matched for age and year of delivery were genotyped. Homozygosity of the -514T allele of the -514C > T polymorphism (LIPC gene) decreased the risk of GH (OR = 0.17, CI 95 : 0.02-0.76), while there were more -60G carriers of the -60C > G LIPE gene polymorphism (OR = 3.51, CI 95 :1.02-12.10) among GH cases, but not in PE cases. The common ApoCIII two-locus -482CC/3238CC genotype was lower in women with GH compared with controls (OR = 0.53, CI 95 : 0.3-0.9). The combined frequency of at-risk genotypes was higher in cases of GH compared with controls [one at-risk genotype: OR = 3.38 (95% CI: 0.48-41.8); two or more at-risk genotypes: OR = 7.14 (95% CI: 1.21-92.3, P = 0.01)], suggesting a gene-dose effect. We conclude that the combined effect of LIPC, LIPE and ApoCIII gene polymorphisms may increase the likelihood of GH, but seemingly not of PE.

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Common Genetic Variants of Lipoprotein Lipase and Apolipoproteins AI–CIII That Relate to Coronary Artery Disease: A Study in Chinese and European Subjects

Cited by 20 publications

References 22 publications

Population prevalence of APOE, APOC3 and PPAR-α mutations associated to hypertriglyceridemia in French Canadians

Population prevalence of APOE, APOC3 and PPAR-α mutations associated to hypertriglyceridemia in French Canadians

Association of two apolipoprotein A-I gene MspI polymorphisms with lipid and blood pressure levels

The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension

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