Apolipoprotein A5 gene variants and the risk of coronary heart disease: A case-control study and meta-analysis

Abstract

Previous studies have shown that apolipoprotein A5 (APOA5) gene variants are genetic determinants of the concentration of triglycerides, which are a known risk factor for coronary heart disease (CHD). Using the standardized coronary angiography method, 290 CHD patients and 198 non-CHD controls were recruited from Ningbo Lihuili Hospital. In addition, 331 unrelated healthy volunteers were recruited as healthy controls from Ningbo Ximen Community residents. Three variants of the APOA5 gene, S19W, -1131T>C and 553G>T, were analyzed for their association with CHD. Under a dominant inheritance model, -1131CT>C was shown to be a CHD risk factor (P=0.030; OR, 1.422; 95% CI, 1.036–1.952). The single nucleotide polymorphism, 553G>T, was found to correlate with the severity of CHD in males (P=0.032). Meta-analysis showed that -1131T>C was significantly associated with CHD (P<0.0001). By contrast, negative correlations with CHD were observed for S19W and 553G>T. In the present case-control study, APOA5 gene variants were not found to correlate with the risk of CHD in the populations studied; however, -1131CT>C was shown to be a CHD risk factor under a dominant inheritance model. Meta-analysis showed a significant contribution of -1131T>C to the risk of CHD, implying an ethnic difference in APOA5 gene variants.

A Replication Study and a Meta-Analysis of the Association between the CDKN2A rs1333049 Polymorphism and Coronary Heart Disease

“…We have previously evaluated several polymorphisms associated with the risk of CHD in Chinese [18][19][20][21] . The current study observed significant associations in both men and women, with women being more at risk (men: OR = 1.29, allele p = 0.01, women: OR = 1.64, allele p = 3.92E-04).…”

APOA5 -1131T>C and APOC3 -455T>C polymorphisms are associated with an increased risk of coronary heart disease

“…To investigate the correlation between APOA5 -1131T>C and APOC3 -455T>C SNPs and CHD, we conducted the present meta-analysis and found that both polymorphisms, under both allelic and dominant models, were positively associated with an increased risk of CHD. APOA5 encodes APOA5, a protein consisting of 366 amino acids that is exclusively expressed in human liver tissue and enhances LPL activity (Zhou et al, 2013). The loss of LPL activity interferes with the ability of APOA5 to interact with lipids and lipoproteins, including TGs, VLDLs, and HDLs (Dorfmeister et al, 2008;Johansen et al, 2011).…”

“…Several polymorphisms have been found in the APOC3 gene, including C-482T, T-455C, Sst I, and C1100T. Moreover, accumulating evidence suggests that APOA5 -1131T>C and APOC3 -455T>C polymorphisms play a major role in the development of CHD because of their association with increased plasma TGs (Zhang et al, 2011;Zhou et al, 2013;Cui et al, 2014). On the other hand, many studies have reached contradictory conclusions regarding the role of APOC3 and APOA5 variants in CHD (Martinelli et al, 2007;Maasz et al, 2008;Prochaska et al, 2010;Yu et al, 2011).…”

Association of G894T eNOS, 4G/5G PAI and T1131C APOA5 polymorphisms with susceptibility to myocardial infarction in Morocco

“…Literature report that about 50% of their final levels are genetically determined (Hubáček et al, 2009). Numerous studies have reported a significant association between the T1131C APOA5 variant and cardiovascular diseases development, especially myocardial infarction (MI) (Hubáček et al, 2003(Hubáček et al, , 2009Hubacek et al, 2004;Szalai et al, 2004;Zhou et al, 2013;Ouatou et al, 2014). However, this association was not observed in many other studies (Prochaska et al, 2010;Martinelli et al, 2007;Lee et al, 2004).…”