APOA5 -1131T>C and APOC3 -455T>C polymorphisms are associated with an increased risk of coronary heart disease

Abstract

ABSTRACT. The aim of this study was to investigate correlations between apolipoprotein A-V (APOA5) -1131T>C and apolipoprotein C-III (APOC3) -455T>C polymorphisms and coronary heart disease (CHD). PubMed, Ovid, Cochrane Library, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched using combinations of keywords relating to these polymorphisms and CHD. Studies retrieved from database searches were screened using our stringent inclusion and exclusion criteria, and Comprehensive Meta-Analysis Version 2.0 software was used for statistical analyses. In total, 115 studies were initially retrieved and after further selection, 11 were included in the metaanalysis. These 11 articles comprised 4840 patients with CHD in the case group and 4913 healthy participants in the control group. Meta-analysis revealed that APOA5 -1131T>C and APOC3 -455T>C polymorphisms increased CHD risk. In addition, subgroup analysis by ethnicity showed that while the -1131T>C polymorphism elevated the risk of CHD in the Caucasian population under both allelic and dominant models, this increased risk was observed only under a dominant model in the Asian 18219 APOA5 and APOC3 polymorphisms and coronary heart disease ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18218-18228 (2015) population. The results of our meta-analysis point to a strong link between both APOA5 -1131T>C and APOC3 -455T>C polymorphisms and an increased risk of CHD. Thus, these polymorphisms constitute important predictive indicators of CHD susceptibility.

Why Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular Disease?

“…Recently, a comprehensive meta-analysis of three main apoC-III polymorphisms (SstI, T-455C, and C-482T) known to associate with hypertriglyceridemia in mice [ 36 ] reported that two polymorphisms (SstI and T-455C) significantly increased the susceptibility to CHD in humans [ 70 ]. The association of the apoC-III T-455C with increased CVD risk was confirmed in another meta-analysis [ 71 ]. In contrast, some evidence emerged that rare variants of apoC-III associated with low triglycerides and high HDL cholesterol [ 72 , 73 ].…”

New insights into apolipoprotein A5 in controlling lipoprotein metabolism in obesity and the metabolic syndrome patients

“…Nevertheless, it should be noted that the association of -1131 T > C SNP with metabolic syndrome was not found in German, Austrian and Turkish populations. The ethnic differences in minor allele frequency of -1131 T > C SNP, from 35.3% in Japanese [ 55 ] and 28.3% in Chinese populations [ 52 ] to 12.8% in a Turkish population [ 56 ] and 7.5% in Caucasian populations [ 57 ], may explain this discrepancy, suggesting an ethnic-specific effect of genetic variants in APOA5 on the risk of metabolic syndrome.…”

Association of c.56C > G (rs3135506) Apolipoprotein A5 Gene Polymorphism with Coronary Artery Disease in Moroccan Subjects: A Case-Control Study and an Updated Meta-Analysis

“…This discrepancy could be explained by the differences between ethnic populations that can contribute to the variation of prevalence rates of CAD. Furthermore, new studies are continuously being performed to identify whether APOA5 polymorphisms are associated with cardiovascular diseases occurrence [ 20 – 23 ]. In addition, accumulated data make it possible to conduct cumulative meta-analysis and assess the effects of APOA5 polymorphisms.…”

“…To date, more than 13 polymorphic sites of APOA5 have been reported [ 24 – 26 ]. Indeed, several studies in different populations have found the association between the APOA5 polymorphisms and the risk of CAD [ 18 , 20 , 27 ]. The APOA5 gene polymorphism, c.56C > G variant located in the exon3, is of a special interest and has been reported to be associated with an increased risk of CAD in multiple ethnic populations probably through its association with hypertriglyceridemia [ 3 , 12 ].…”