Apolipoprotein A5-1131T&gt;C polymorphism, but not APOE genotypes, increases susceptibility for dyslipidemia in children and adolescents

Brito, Daniela Diniz Viana de; Fernandes, Ana Paula; Gomes, Karina Braga; Coelho, Fernanda Fonseca; Cruz, N.G.; Sabino, Adriano de Paula; Cardoso, Jarbas E.; Figueiredo-Filho, P. P.; Diamante, Rafael; Norton, Catherine; Sousa, Marinez O.

doi:10.1007/s11033-010-0565-5

Cited by 15 publications

(15 citation statements)

References 53 publications

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“…Also, it is important to highlight that menopause; a factor associ-ated to development of dyslipidemia (21) was more frequent among the dyslipidemic women included in this study. The observed frequency for the ApoA5 −1131C allele among both dyslipidemic subjects and controls were comparable to that described in African-American and Hispanic (10) , and French populations (22) , but lower than that in Chinese (23) and Japanese populations (24) . The high C allele frequency observed in dyslipidemic subjects compared to controls, has been previously described in other dyslipidemic groups (25)(26)(27)(28) .…”

Section: Discussionsupporting

confidence: 75%

Association of Apolipoprotein A5 Polymorphism -1131T>C with Dyslipidemia in Suez Canal Area

El-Shabrawi

Mahmoud

2012

Suez Canal University Medical Journal

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Aim: Polymorphisms in apolipoprotein A5 gene (APOA5) have been associated with higher triglyceride levels in many populations. The aim of this study was to determine the distribution of alleles and genotypes of the apoA5-1131T>C polymorphism, as well as to show the association of the genetic variant and the risk for the development of dyslipidemia among Egyptians. Patients and Methods: One hundred and fifty patients with dyslipidemia were included in this study. Additional 150 subjects without dyslipidemia served as a control group. ApoA5-1131T>C polymorphism was determined using PCR-RFLP technique. The total cholesterol, triglycerides, and HDL-c were determined enzymatically. Comparison of means among groups was calculated by ANOVA. Significant differences among groups were evaluated by Student-Newman-Keuls test. Results: The polymorphic allele C was found to be more frequent among subjects with dyslipidemia than control (p=0.019). It imparts an additional individual risk factor for dyslipidemia (OR=1.7, 95% IC=1.09-2.72). The polymorphic allele C was more frequent among dyslipidemic males (OR=2.1, 95% IC=1.04-4.02, p=0.037). Subjects carried the polymorphic allele C (genotypes TC/ CC) showed higher cholesterol and triglycerides levels than subjects with genotype TT (p=0.042 and 0.041 respectively). Conclusion: There is a strong association between ApoA5-1131T>C and dyslipidemia. This association is more obvious among males.

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Section: Discussionsupporting

confidence: 75%

Association of Apolipoprotein A5 Polymorphism -1131T>C with Dyslipidemia in Suez Canal Area

El-Shabrawi

Mahmoud

2012

Suez Canal University Medical Journal

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“…[17]. The human APO E gene is located in chromosome 19q and encodes 3 polymorphic alleles -ε2, ε3, and ε4, that produces 3 different isoforms -E2, E3 and E4, which have been associated with high plasma lipids levels and CVDs [14,18].…”

Section: Polymorphisms In Apolipoprotein Genesmentioning

confidence: 99%

“…Several studies have shown that presence of the APO E ε4 allele (APOE c.471T > C, rs7412) is associated with higher levels of LDL-C and TC, in addition to CHD, while the presence of APO E ε2 allele (APOE c.609C > T, rs429358) is associated with low levels of LDL-C and increased concentrations of plasma TG and lipoprotein remnants, in different populations [17,18,21].…”

Section: Polymorphisms In Apolipoprotein Genesmentioning

confidence: 99%

“…We have evaluated, in a case-control study, 130 children and adolescents (2-19 yr of age) from Brazil [18]. The case group was defined as individuals with a clinical diagnosis of hypercholesterolemia and/or hypertriglyceridemia; the control group included normolipidemic subjects without clinical and laboratorial changes.…”

Section: Polymorphisms In Apolipoprotein Genesmentioning

confidence: 99%

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Genetic polymorphisms as a risk factor for dyslipidemia in children

et al. 2015

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Dyslipidemia is an important etiological factor for development of cardiovascular disease, which is the leading cause of deaths in adults. Given the growing global epidemic of dyslipidemia, lipoprotein metabolism disorders have become an important health problem not only in adulthood, but have also emerged as an increasingly risk factor in childhood. Although several genome-wide association studies in multiple large population-based cohorts of adults and meta-analyses have identified susceptibility genes or loci, especially in lipid-related traits, it is of great importance to evaluate genetic predisposition at an early age. Recent findings suggest that the identification of polymorphisms in the metabolism of lipids in childhood may help fight subclinical atherosclerosis and its progression to cardiovascular complications in adulthood. Therefore, the aim of this study was to review genetic polymorphisms as risk factors associated with dyslipidemia in children and adolescents.

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“…[4][5][6] It is associated with the metabolism of triglyceride (TG). 7 The TG accumulation in kidney is associated with the kidney injury. 8 At the presented data, some reports showed that apoE gene polymorphism was associated with the expression of TG.…”

Section: Introductionmentioning

confidence: 99%

Relationship between apolipoprotein E gene polymorphism with triglyceride level in patients with renal diseases

et al. 2013

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Apolipoprotein E (apoE), one of the major plasma lipoproteins, plays a major role in the transport and metabolism of lipids by acting as a ligand. apoE gene contains three potential alleles: e2, e3 and e4, forming six genotypes: E2E2, E2E3, E2E4, E3E3, E3E3 and E4E4. Association between apoE gene polymorphism and triglyceride (TG) is still controversial. There was no any meta-analysis to explore the association of apoE gene polymorphism with triglyceride level, and this meta-analysis was performed to evaluate the association between apoE gene polymorphism and triglyceride in patients with renal diseases. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Twenty-four articles were identified for the analysis of association between apoE gene polymorphism and triglyceride level. Subjects with E2E3 or E3E4 had a higher TG than those with E3E3. Subjects with e4 had a higher TG than those with e3. Subjects with e2 had a slightly higher TG than those with e3, although there was no statistical difference. Interestingly, subjects with e4 had a much higher TG than those with e2. In conclusion, E2E3, E3E4 or e4 was associated with higher level of TG. However, more studies should be performed in the future.

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Apolipoprotein A5-1131T>C polymorphism, but not APOE genotypes, increases susceptibility for dyslipidemia in children and adolescents

Cited by 15 publications

References 53 publications

Association of Apolipoprotein A5 Polymorphism -1131T>C with Dyslipidemia in Suez Canal Area

Association of Apolipoprotein A5 Polymorphism -1131T>C with Dyslipidemia in Suez Canal Area

Genetic polymorphisms as a risk factor for dyslipidemia in children

Relationship between apolipoprotein E gene polymorphism with triglyceride level in patients with renal diseases

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