Association of Apolipoprotein A5 Polymorphism -1131T>C with Dyslipidemia in Suez Canal Area

Abstract

Aim: Polymorphisms in apolipoprotein A5 gene (APOA5) have been associated with higher triglyceride levels in many populations. The aim of this study was to determine the distribution of alleles and genotypes of the apoA5-1131T>C polymorphism, as well as to show the association of the genetic variant and the risk for the development of dyslipidemia among Egyptians. Patients and Methods: One hundred and fifty patients with dyslipidemia were included in this study. Additional 150 subjects without dyslipidemia served as a control group. ApoA5-1131T>C polymorphism was determined using PCR-RFLP technique. The total cholesterol, triglycerides, and HDL-c were determined enzymatically. Comparison of means among groups was calculated by ANOVA. Significant differences among groups were evaluated by Student-Newman-Keuls test. Results: The polymorphic allele C was found to be more frequent among subjects with dyslipidemia than control (p=0.019). It imparts an additional individual risk factor for dyslipidemia (OR=1.7, 95% IC=1.09-2.72). The polymorphic allele C was more frequent among dyslipidemic males (OR=2.1, 95% IC=1.04-4.02, p=0.037). Subjects carried the polymorphic allele C (genotypes TC/ CC) showed higher cholesterol and triglycerides levels than subjects with genotype TT (p=0.042 and 0.041 respectively). Conclusion: There is a strong association between ApoA5-1131T>C and dyslipidemia. This association is more obvious among males.