Apolipoprotein A-I, apolipoprotein B, high-sensitivity C-reactive protein and severity of coronary artery disease in tunisian population

Hrira, Mohamed Yahia; Kerkeni, Mohsen; Hamda, Ben Khaldoun; Chahed, H.; Ferchichi, Salima; Addad, Faouzi; Limam, Halima Ben; Miled, Abdelhédi

doi:10.1016/j.carpath.2012.02.009

Cited by 6 publications

(9 citation statements)

References 42 publications

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“…26 In a recent study by Hrira et al reported that ApoB and hs-CRP levels were markedly associated with the severity of CAD in Tunisian patients and their findings are similar to our results. 27 The possible limitations of our study are limited number of subjects and cross sectional design. Prospective studies on large scale are needed to explore the true pathogenic role of hsCRP in assessing cardiovascular risk.…”

Section: Discussionmentioning

confidence: 91%

Relationship of high sensitivity C-reactive protein with presence and severity of coronary artery disease

Habib¹,

Masri²

2013

Pak J Med Sci

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Objective: Inflammation plays a key role in the pathogenesis of atherosclerosis. This study aimed to assess the relationship of serum inflammatory marker high sensitivity C Reactive protein (hsCRP), with the presence and severity of angiographically evaluated coronary artery disease (CAD). Methods: This study was conducted at departments of physiology and cardiology, College of Medicine & King Khalid University Hospital, King Saud University, Riyadh from August 2009 to March 2012. Eighty seven patients (57 males and 30 females) with angiographically evaluated CAD were studied. In all these patients CAD severity was assessed by Gensini scoring and vessel scoring. Control group consisted of 29 healthy subjects (17 males and 12 females). Fasting venous blood samples were analyzed for lipid profile and high sensitivity C-reactive protein (hsCRP). Results: There were non-significant differences in age, weight and BMI among healthy subjects and CAD patients. Comparison of lipid profile between control and CAD patients showed that CAD patients had significantly higher TG and significantly lower HDL levels compared to control subjects. CAD patients presented with significantly higherhsCRP levels than controls. Linear regression analysis between hsCRP and CAD severity determined by Gensini scores showed a significant positive correlation (r=0.423, p=0.018). Triple vessel disease patients had significantly higher hsCRP levels than one vessel and two vessel disease, while the difference was non significant between one and two vessel disease groups. Conclusions: These results suggest that patients with angiographically evaluated CAD have significantly higher levels of hsCRP levels compared to healthy individuals and are correlated with the presence & severity of CAD.

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Section: Discussionmentioning

confidence: 91%

Relationship of high sensitivity C-reactive protein with presence and severity of coronary artery disease

Habib¹,

Masri²

2013

Pak J Med Sci

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“…Varied risk factors among patients confirm the multifactorial and polygenic origin of the ACS, well explained by the Framingham study [13, 14]. Partially balanced lipid profile in patients is caused by the diet, recommended by medical staff, by lipid-lowering therapy and in particular by the beneficial impact of the ACE inhibitors that enhance of the glucose sensitivity and the correction of lipid metabolism [14, 15].…”

Section: Discussionmentioning

confidence: 93%

“…Partially balanced lipid profile in patients is caused by the diet, recommended by medical staff, by lipid-lowering therapy and in particular by the beneficial impact of the ACE inhibitors that enhance of the glucose sensitivity and the correction of lipid metabolism [14, 15]. …”

Section: Discussionmentioning

confidence: 99%

“…Unlike reversible dyslipidemia (only related to diet and lifestyle), easy to corrected by statins, mixed and genetic dyslipidemia requires a combined medication (statins + fibrates, or nicotinic acid) whereas Apo A1 (statistically higher in healthy croup) has acardio-protective effect supported by various studies. These apolipoproteins are under genetic control which showed the polygenic origin of ACS [4, 14, 16]. …”

Section: Discussionmentioning

confidence: 99%

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Pathological interactions between the endothelin-1 and the angiotensin- converting enzyme among Tunisian coronary patients

Chalghoum

Noichri

Dandana

et al. 2016

BMC Cardiovasc Disord

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BackgroundThe correct understanding of the biochemical and metabolic interactions between coronary risk factors contribute to the exploration of cardiovascular pathophysiology and improves therapeutic care.The aim of this study was to explore the endothelin-1 (ET-1) concentration and the angiotensin converting enzyme (ACE) activity among Tunisian patients with coronary heart disease, and to investigate the metabolic relationships between these two markers,… and to assess the possible relationship between them and the different risk factors.In this present study, ET-1 concentration was determined by an analytical method (High Performance Chromatography, coupled by Mass Spectrometry), ACE activity was measured by a kinetic method for patients and healthy controls. These subjects (157 patients and 142 controls) beneficed also by a biochemical exploration (lipid, apolipoproteins and glucose profiles) to quantify cardiovascular risk.ResultsA statistically significant increase of the ET-1 concentration was found among patients compared to healthy controls (15.2 ± 5.3 nM vs 7.1 ± 2.7 nM, p < 0,00001). For the ACE activity, in spite the treatment of the majority of patients (97%) with ACE inhibitors, this activity was statistically elevated in patients compared to healthy subjects (86.7 ± 25.4 IU/L vs 42.8 ± 12.1 IU/L, p < 0.00001).Furthermore, a statistically positive correlation was identified between these two cardiac markers (r = 0.68 p < 0.00001).ConclusionThe study of the metabolic relationship between the ET-1 and ACE among coronary patients reveals other therapeutics targets.

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“…Coronary artery disease (CAD) is a multifactorial disease that combines genetic and environmental factors [1]. CAD is a complex disease with high morbidity and mortality in Tunisian population [2].…”

Section: Introductionmentioning

confidence: 99%

Hsp70-2 gene polymorphism: susceptibility implication in Tunisian patients with coronary artery disease

et al. 2012

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Coronary artery disease (CAD) is a multifactorial disease where genetic and environmental factors interact in complex ways to cause the disease. Heat shock protein genes are involved in the progress of CAD. This implies that genetic variants of Hsp70–2 genes might contribute to the development of the CAD.Aim of studyThe aim of this study was to characterize statistical correlation of linkage between lipid profiles, polymorphism PstI site of Hsp70–2 gene and CAD.Patients and methodsThis study was carried out on Tunisian patients with CAD recruited from Hospital of Fattouma Bourguiba of Monastir-Tunisia. Polymerase chain reaction and restriction enzymes were used to determine the genotypic distributions in 252 unrelated patients and 151 healthy control subjects. Further, ApoA-I and ApoB as well as the serum total of cholesterol, HDL, triglyceride, and hs-CRP levels were measured.ResultsWe showed a decreased level of ApoA-I, whereas the levels of each of ApoB and hs-CRP were increased in patients with CAD compared with control group. In addition our studies of a polymorphic PstI site of Hsp70-2 gene at position 1267 of the Hsp70–2 gene have revealed that the allelic frequency of P2 was significantly more frequent in CAD patients than controls group (p=0.007, OR=1.495). The genotypic distribution showed a high incidence of P2/P2 genotype in CAD patients (0.190) compared to healthy control (0.009) with reach significant difference (p=0.006). The P2 carriers showed a significantly increased of Total-Cholesterol (CT) and C-reactive protein (hs-CRP) levels in CAD patients (p=0.008 and p=0.018, respectively).ConclusionThe high incidence of P2-Hsp70-2 genotype in CAD patients and the significantly association of P2/P2 genotype with elevated Total Cholesterol and hs-CRP levels, supported that P2–Hsp70–2 genotype has susceptibility implication in CAD and could increased the risk of CAD in Tunisian population.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1118340895703689

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Apolipoprotein A-I, apolipoprotein B, high-sensitivity C-reactive protein and severity of coronary artery disease in tunisian population

Cited by 6 publications

References 42 publications

Relationship of high sensitivity C-reactive protein with presence and severity of coronary artery disease

Relationship of high sensitivity C-reactive protein with presence and severity of coronary artery disease

Pathological interactions between the endothelin-1 and the angiotensin- converting enzyme among Tunisian coronary patients

Hsp70-2 gene polymorphism: susceptibility implication in Tunisian patients with coronary artery disease

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