ApoE ɛ4 genotype and the age at onset of temporal lobe epilepsy: A case–control study and meta-analysis

Kauffman, Marcelo; Consalvo, D.; Morón, Dolores González; Lereis, Virginia Pujol; Kochen, Sara Silvia

doi:10.1016/j.eplepsyres.2010.05.007

Cited by 33 publications

(17 citation statements)

References 34 publications

(42 reference statements)

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“…In contrast to this, there was no difference in the age at onset of epilepsy in patients with focal seizures with copy of the e2, e3 or e4 allele in studies by Kilpatric et al 18 and Blumke et al 19 . Th e same result has been reported by Yeni et al 20 in a group of patients suff ering from mesial temporal lobe epilepsy-hippocampal sclerosis, and by Kauff man et al 21 .…”

Section: Discussionsupporting

confidence: 78%

Is Apolipoprotein E ε2 Associated with Delayed Onset of Non-Lesional Temporal Lobe Epilepsy?

Sporiš

Bašić

Sertić

et al. 2017

acc

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SUMMARY -Th e aim of the study was to evaluate the possible association between Apo E polymorphisms and age at seizure onset in patients with non-lesional temporal lobe epilepsy. Eighty patients with non-lesional temporal lobe epilepsy with or without bilateral tonic-clonic propagation were analyzed. Age at seizure onset was defi ned as age at the fi rst unequivocal seizure (excluding febrile convulsions). ApoE alleles were determined by a procedure where genome DNA was amplifi ed by chain reaction along with polymerase, using the LightCycler kit (Roche) for ApoE mutations on codons 112 and 158. Th ere was a statistically signifi cant diff erence between the groups of patients with ApoE ε2/3 and ε3/4 genotypes (p=0.03), but not between patients with ApoE ε2/3 and ε3/3, and those with ApoE ε3/4 and ε3/3. In conclusion, the results of our study suggested positive association of a specifi c ApoE genotype and onset of non-lesional temporal lobe epilepsy.

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Section: Discussionsupporting

confidence: 78%

Is Apolipoprotein E ε2 Associated with Delayed Onset of Non-Lesional Temporal Lobe Epilepsy?

Sporiš

Bašić

Sertić

et al. 2017

acc

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“…A meta-analysis showed that APOE ϵ4 allele appeared to be associated with a higher prevalence of dementia in Parkinson disease [44]. A meta-analysis suggested that the APOE ϵ4 isoform was a genetic factor that might influence the age at onset of temporal lobe epilepsy [45]. A meta-analysis showed that the APOE ϵ4 allele was associated with an increased risk of developing hypertension [46].…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E gene polymorphism and the risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies

Zhang¹,

Wang²,

Tang³

et al. 2014

Lipids Health Dis

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BackgroundStudies investigating the association between the apolipoprotein E (APOE) gene polymorphism and the risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship.MethodsPublished literature from the National Library of Medline and Embase databases were retrieved. Odds ratio (OR) and 95% confidence interval (CI) were calculated in fixed- or random-effects models when appropriate. Subgroup analyses were performed by race.ResultsThis meta-analysis included 11 case–control studies, which included 1,238 ICH cases and 3,575 controls. The combined results based on all studies showed that ICH cases had a significantly higher frequency of APOE ϵ4 allele (OR= 1.42, 95% CI= 1.21,1.67, P<0.001). In the subgroup analysis by race, we also found that ICH cases had a significantly higher frequency of APOE ϵ4 allele in Asians (OR= 1.52, 95% CI= 1.20,1.93, P<0.001) and in Caucasians (OR= 1.34, 95% CI= 1.07,1.66, P=0.009). There was no significant relationship between APOE ϵ2 allele and the risk of ICH.ConclusionOur meta-analysis suggested that APOE ϵ4 allele was associated with a higher risk of ICH.

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“…23 The association between the presence of the APOEe4 allele and epilepsy in our study may be consistent with a few smaller studies on the genetic background of epilepsy in children without CP. 24 However, most of these studies have been done in children with chronic temporal lobe epilepsy, and most reports on the association between APOEe4 and epilepsy have been inconclusive. 25,26 At the same time, there are several studies in adults with posttraumatic seizures pointing to a seemingly unfavourable effect of the APOEe4 allele.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E polymorphisms and severity of cerebral palsy: a cross‐sectional study in 255 children in Norway

Lien

Andersen

Bao

et al. 2013

Develop Med Child Neuro

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Aim The aim of this study was to examine whether the presence of the apolipoprotein E (ApoE) allele APOEε4 is associated with less severe manifestations of cerebral palsy (CP), consistent with the suggested beneficial effect of this allele on neurodevelopment in children. Method ApoE genotyping was performed on buccal epithelial cells from 255 children (141 males 114 females; mean age 12y, SD 2y 3mo, range 9–17y) recorded in the Cerebral Palsy Register of Norway. The main outcome measure of CP severity was the Gross Motor Function Classification System (GMFCS). Secondary outcome measures were fine motor function, epilepsy, and the need for gastrostomy tube feeding (GTF). Results There was no association between the APOEε4 genotype and GMFCS levels (odds ratio [OR] 1.15; 95% confidence interval [CI] 0.66–1.99). However, the APOEε4 genotype was more often present among children with epilepsy (OR 2.2; 95% CI 1.1–4.2) and/or receiving GTF (OR 2.7; 95% CI 1.1–6.6). Among children with unilateral CP, the presence of APOEε4 was associated with more severe fine motor impairment (OR 2.6; 95% CI 1.3–6.9). Interpretation Our main hypothesis that APOEε4 would have a protective effect on neurodevelopment was not supported. Instead, subgroup analyses suggested an adverse effect of the APOEε4 genotype on the developing brain after injury.

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ApoE ɛ4 genotype and the age at onset of temporal lobe epilepsy: A case–control study and meta-analysis

Cited by 33 publications

References 34 publications

Is Apolipoprotein E ε2 Associated with Delayed Onset of Non-Lesional Temporal Lobe Epilepsy?

Is Apolipoprotein E ε2 Associated with Delayed Onset of Non-Lesional Temporal Lobe Epilepsy?

Apolipoprotein E gene polymorphism and the risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies

Apolipoprotein E polymorphisms and severity of cerebral palsy: a cross‐sectional study in 255 children in Norway

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