Aplastic anemia: the correct nomenclature matters

Cuglievan, Branko; DePombo, April; Angulo, Guillermo De

doi:10.3324/haematol.2016.146522

Cited by 9 publications

(5 citation statements)

References 5 publications

(1 reference statement)

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“…Unlike genetic disorders, AA is typically acquired, stemming from immune reactions, exposure to specific medications and certain viral infections [ 14 ]. The intersection of pregnancy with AA has intrigued researchers since Paul Ehrlich's first report of the condition in 1888, in which the patient, who was pregnant, succumbed to postpartum haemorrhage a month after giving birth [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…This condition was first identified by Paul Ehrlich, a Nobel Prize-winning German physician and scientist, in 1885 during a post-mortem examination of a young pregnant female who died after a rapid, severe illness. It was not until 1904 that the term 'aplastic anaemia' was coined by Anatole Chauffard [ 2 ]. The quest for understanding AA's diagnosis and treatment has continued since its discovery.…”

Section: Introductionmentioning

confidence: 99%

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Aplastic Anaemia in Pregnancy: A Case-Based Comprehensive Review of the Literature

Perolla,

Cela,

Semanaj

et al. 2024

Cureus

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Aplastic anaemia (AA) is a rare and life-threatening haematologic disorder characterised by pancytopenia and bone marrow failure. Its occurrence during pregnancy is exceedingly rare, posing significant risks and management challenges for both the mother and the foetus. We present here the case of a 23-year-old female, six months pregnant, diagnosed with severe aplastic anaemia (AA), aiming to highlight the diagnostic challenges and management considerations of AA in pregnancy. Our case underscores the critical nature of considering aplastic anaemia in differential diagnosis for pregnant patients presenting with unexplained pancytopenia. Based on that, we performed a comprehensive literature review of the past 20 years of papers published in the English language identified through searches in PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), Embase and the Cochrane Library, to provide an in-depth analysis of the current understanding of AA in pregnancy. We emphasise the necessity for cautious yet thorough investigation in such cases to avoid complications in both maternal and foetal health, focusing attention on the need for further research into safe and effective treatment protocols for managing AA in pregnancy, given the complexities introduced by the condition and its treatment on pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aplastic Anaemia in Pregnancy: A Case-Based Comprehensive Review of the Literature

Perolla,

Cela,

Semanaj

et al. 2024

Cureus

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“…The misleading and confusing terminology "aplastic anemia" is another related issue considering pancytopenia, with decreased platelets, with cells, and erythrocytes, as the main characteristic of the condition. Such a bone marrow failure of this nature should be called "Aplastic pancytopenia" [1,21]. Perhaps this proposal might be placed in an international congress of hematology.…”

Section: Discussionmentioning

confidence: 99%

Aplastic Anemia-Related Mortality in Brazil, 2000-2018

Hasiak¹

2022

Int J Blood Res Disords

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Background: Nationwide population aplastic anemiarelated mortality is rare in the world medical literature. Methods:The annual AA mortality data was extracted from the public databases of the Mortality Information System, searching category D61 "other aplastic anemias" of the International Classification of Diseases, Tenth Revision. : In Brazil, 2000to 2018 as underlying cause, and 21,894 (61.6%) as associated (non-underlying) cause of death. Average standardized mortality rates were for underlying, associated and all mentions cause deaths, respectively, 4.02, 6.40 and 10.42 deaths per million population. The overall mean and median ages at death for all mentions were, respectively, 51.5 (± 24.7) and 55.5 (range 32.5-71.5) years. On certificates with AA as an associated cause, the underlying causes of deaths were neoplasms (38.9%), infectious and parasitic diseases (8.8%) of the circulatory system (8.7%); the main underlying causes among the neoplasms were myeloid leukemia (7.7%), lymphoid leukemia (5.1%), other and specified types of non-Hodgkin's lymphoma (4.1%), certain other neoplasm of lymphoid, hematopoietic and related tissue (3.5%), and neoplasms of the digestive organs (3.2%). The leading overall associated cause of death was septicemia, occurring in 48.9% among AA as the underlying cause and 42.6% among other underlying conditions, followed by pneumonias, respiratory failure, failure of multiple organs, renal failure, and cerebrovascular diseases. Main results Conclusion:This study revised AA death rate trends, underlying and associated causes of death, age at death and regional distribution of death in Brazil.

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“…It is characterized by the combination of peripheral-pancytopenia and bone-marrow hypo-cellularity. 1 Certain environmental 2 and host related factors begin the autoimmune reaction, 3 leading to bone-marrow failure (disease development). Only one case–control study highlighted the environment risk factors for AA in Pakistan.…”

Section: Introductionmentioning

confidence: 99%

Pesticides and Chemicals as Potential Risk Factors of Aplastic Anemia: A Case–Control Study Among a Pakistani Population

Syed

Rahman

Siddiqui

et al. 2021

CLEP

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Introduction Aplastic anemia is a rare and potentially life-threatening hematological disorder with incidence of 1.4 to 14 cases/million. It is associated with exposures to certain environmental chemicals, drugs and infections. The objective was to investigate the association of illness with family history of aplastic anemia, exposure to pesticides and chemicals. Methodology A hospital-based case–control study (191 cases, 696 controls) was conducted from 1st January 2015 to 31st December 2018 in Karachi, Sindh. Cases were patients with diagnosis of aplastic anemia confirmed with bone marrow biopsy. Controls neither had aplastic anemia nor other hematological chronic diseases. An in-person interview was conducted to collect demographic information, family history of aplastic anemia, and history of pesticide and chemical exposure. The adjusted odds ratios (aOR) with 95% confidence intervals (CI) were estimated via SPSS v22. Results A total of 191 confirmed aplastic anemia cases were selected. Mean age was 29 years (range: 4–69) and predominantly there were males 129 (67.5%). The majority, 84 (44.0%), of the cases were aged 16–30 years. In multivariate analysis models, the significant associations were observed between aplastic anemia with family history of aplastic anemia (aOR=13.3, 95% C.I 3.66–48.50), exposure to pesticides (aOR=2.1, 95% C.I 1.23–3.61) and chemicals (aOR=3.6, 95% C.I 2.06–6.34). Conclusion This study observed a significant association of aplastic anemia with family history of aplastic anemia, exposure to pesticide and insecticide exposure. However, to establish this connection, further longitudinal studies are warranted.

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Aplastic anemia: the correct nomenclature matters

Cited by 9 publications

References 5 publications

Aplastic Anaemia in Pregnancy: A Case-Based Comprehensive Review of the Literature

Aplastic Anaemia in Pregnancy: A Case-Based Comprehensive Review of the Literature

Aplastic Anemia-Related Mortality in Brazil, 2000-2018

Pesticides and Chemicals as Potential Risk Factors of Aplastic Anemia: A Case–Control Study Among a Pakistani Population

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