Aplastic anemia in China

Liu, Chunyan; Shao, Zonghong

doi:10.2478/jtim-2018-0028

Cited by 14 publications

(15 citation statements)

References 16 publications

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“…In the course of exploring the pathogenesis of SAA, it was found that the number of mDCs in SAA patients was significantly higher than that of normal people, and the ratio of mDC/pDC was significantly increased (15)(16)(17)(18). The expression of costimulatory molecule CD86 on the surface of mDCs was significantly increased (5).…”

Section: Discussionmentioning

confidence: 99%

Upregulated Expression of Profilin1 on Dendritic Cells in Patients With Severe Aplastic Anemia

Zhao

Pan

et al. 2021

Front. Immunol.

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Severe aplastic anemia (SAA) is a life-threatening form of bone marrow failure that is associated with very high mortality. Dendritic cells (DCs) are antigen presenting cells (APCs) with powerful movement ability, which is an important factor affecting immune function. The expression of profilin1 (Pfn1) plays an important role in the regulation of cell movement ability. We detected the expression of Pfn1 mRNA in the bone marrow (BM) myeloid dendritic cells (mDCs) from patients with SAA using RT-PCR. Next, we examined Pfn1 expression on mDCs using flow cytometry (FCM). We also assessed the relationship between Pfn1 expression and cytokine levels. Our data showed increased Pfn1 mRNA expression in patients with SAA. The expression of Pfn1 in BM mDCs increased in SAA patients. The expression of Pfn1 on mDCs and cytokines (TNF-α and IFN-γ) were positively correlated in the serum of untreated patients with SAA. Taken together, we found that the expression of Pfn1 on mDCs of SAA patients increased, which may affect the function of mDCs. Profilin 1 may be involved in the immunopathogenesis of SAA.

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Section: Discussionmentioning

confidence: 99%

Upregulated Expression of Profilin1 on Dendritic Cells in Patients With Severe Aplastic Anemia

Zhao

Pan

et al. 2021

Front. Immunol.

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“…The number of new cases of HBP cancer worldwide in 2018 was approximately 1.85 million, accounting for 10% of all newly diagnosed cancer cases and resulting in a great financial burden[ 4 , 5 ]. Due to the large number of HBP cancer cases, from the perspective of prevention[ 6 , 7 ], identifying high-risk populations has become an urgent public health issue[ 8 - 10 ].…”

Section: Introductionmentioning

confidence: 99%

Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study

Huang

et al. 2020

WJG

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BACKGROUND Uric acid is the end product of purine metabolism. Previous studies have found that serum uric acid (SUA) levels are associated with the total cancer risk. However, due to the dual effect of uric acid on cancer, the relationship between the SUA levels and most specific-site cancer remains unclear. AIM To investigate the associations between the SUA levels and incidence of hepatobiliary-pancreatic cancer. METHODS In this prospective cohort study, 444462 participants free of cancer from the UK Biobank were included. The SUA levels were measured at baseline, and the incidence of hepatobiliary-pancreatic cancer was determined by contacting the cancer registry. The hazard ratios (HRs) and 95% confidence intervals (CIs) between the SUA levels and hepatobiliary-pancreatic cancer were investigated using multiple adjusted Cox regression models adjusted for potential confounders. RESULTS In total, 920 participants developed liver, gallbladder, biliary tract or pancreatic cancer during a median of 6.6 yrs of follow-up. We found that the HR of pancreatic cancer in the highest SUA group was 1.77 (95%CI: 1.29-2.42) compared with that in the lowest group. After stratifying by gender, we further found that SUA was associated with an increased risk of pancreatic cancer only among the females (highest quartile vs lowest quartile HR 2.04, 95%CI: 1.35-3.08). Among the males, the SUA levels were positively associated with the gallbladder cancer risk (highest quartile vs lowest quartile HR 3.09, 95%CI: 1.28-7.46), but a U-shaped association with the liver cancer risk was observed ( P -nonlinear = 0.03). CONCLUSION SUA is likely to have gender-specific effects on hepatobiliary-pancreatic cancer. High SUA levels are a risk factor for pancreatic cancer in females and gallbladder cancer in males. A U-shaped association with the liver cancer risk was identified.

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“…To date, the etiology and pathogenesis of SAA have remained to be fully elucidated. Previous studies by our group have confirmed that various immune cells and cytokines constitute an abnormal immune status in patients with SAA (20,21), including the involvement of Th1/Th2 subset imbalances, hyperfunctional CTLs, insufficiencies in the regulatory T and NK cell populations and negative hematopoietic cytokines (22,23). These subsequently induce excessive apoptosis of CD34 + HSCs and inhibit hematopoietic colony formation through the perforin, granzyme B, Fas/FasL and the TNF-related apoptosis-inducing ligand pathways (13).…”

Section: Discussionmentioning

confidence: 72%

“…No statistically significant difference in the expression of LILRA3 was obtained between SAA patients with short-term remission (≤12 months) and long-term remission (>12 months). A significant risk of relapse was reported with rapid tapering of cyclosporine in patients with remission SAA and the treatment should be continued for a long time until the immunoreaction is completely back to normal ( 20 ). LILRA3 upregulated the transcription of IL-1A, IL-1B and IL-6 and modulated the expression of co-stimulatory molecules and MHC in B-cells and monocytes.…”

Section: Discussionmentioning

confidence: 99%

Upregulated expression of leukocyte immunoglobulin‑like receptor A3 in patients with severe aplastic anemia

Liu

Zhao

et al. 2021

Exp Ther Med

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Severe aplastic anemia (SAA) is a rare and potentially life-threatening disease characterized by pancytopenia and bone marrow (BM) hypoplasia. In a previous study by our group, increased expression of leukocyte immunoglobulin-like receptors A (LILRA), LILRA3 in myeloid dendritic cells (mDCs) and LILRA5 in CD34 + cells in SAA was detected using proteomics techniques, highlighting their potential role in disease pathogenesis. In the present study, the expression of LILRA1-6 mRNA was assessed in the BM mononuclear cells of patients with SAA using reverse transcription-quantitative (RT-q)PCR. The expression of homogenic LILRA3 and LILRA5 isoform on mDCs, as well as CD34 + , CD3 + CD8 + , CD19 + and CD14 + cells, was detected using flow cytometry. mDCs were then induced, cultured and sorted. The expression of LILRA3 was confirmed using RT-qPCR and western blot analyses. The serum levels of soluble LILRA3 were measured using ELISA. Furthermore, the relationship between LILRA3 expression and disease severity was assessed. The results indicated increased LILRA3 mRNA expression in patients with SAA. The percentage of LILRA3 + in BM mDCs and CD34 + cells was increased. Compared with controls, the relative LILRA3 mRNA expression and the relative protein intensity were highly increased in SAA mDCs. The serum LILRA3 levels in patients with SAA were also increased. The proportion of LILRA3 + CD11C + human leukocyte antigen (HLA)-DR + /CD11C + HLA-DR + cells was positively correlated with the ratio of LILRA3 + CD34 + /CD34 + cells and the expression of LILRA3 mRNA. Taken together, the expression of LILRA3 on mDCs of patients with SAA was increased, which may affect the function of mDCs. LILRA3 may have a significant role in the immune pathogenesis of SAA.

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Aplastic anemia in China

Cited by 14 publications

References 16 publications

Upregulated Expression of Profilin1 on Dendritic Cells in Patients With Severe Aplastic Anemia

Upregulated Expression of Profilin1 on Dendritic Cells in Patients With Severe Aplastic Anemia

Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study

Upregulated expression of leukocyte immunoglobulin‑like receptor A3 in patients with severe aplastic anemia

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