Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model

Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects?

“…As previously observed with 10 µM and along with reducing LPS-generated free radicals (Ha et al, 2008;Kao et al, 2010), quercetin (20-30 µM) also attenuated the LPS-induced NO production and iNOS protein and gene expressions in a Nrf2-dependent signalling pathway in BV-2 microglial cells (Kang et al, 2013). In addition to the inhibition of iNOS and subsequent NO production, apigenin (10 µM) (Ha et al, 2008) and wogonin (10-30 µM) (Yeh et al, 2014), also decrease the COX-2-dependent PGE2 production in LPS-activated BV-2 cells.…”

Neuroprotective Effect of Matricaria chamomilla Extract on Motor Dysfunction Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

“…A study by Ha et al (2008) showed that apigenininhibited the production of NO by suppressing the expression of inducible NO synthase. It also protects the neuronal cells against injury in middle cerebral artery occlusion [34].…”

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

“…Moreover, apigenin suppressed p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK) phosphorylation without affecting the activity of extracellular signal-regulated kinase (ERK). Apigenin was also found to protect neuronal cells from injury in middle cerebral artery occlusion [71].…”