Apigenin: A dietary flavonoid with diverse anticancer properties

Madunić, Josip; Madunić, Ivana Vrhovac; Gajski, Goran; Popić, Jelena; Garaj‐Vrhovac, Vera

doi:10.1016/j.canlet.2017.10.041

Cited by 284 publications

(165 citation statements)

References 107 publications

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“…The main anti‐cancer approaches include (1) invasion and metastasis prevention, (2) apoptosis or (3) autophagy induction, among which (1) and (2) are reported to be successfully achieved by coptisine treatment in many cancer cell lines to date. Apart from mechanisms mentioned above, cellular senescence is another promising approach in anti‐cancer therapy . It has been reported that berberine, a natural product which shares similar structure with coptisine, induced apoptosis and premature senescence, respectively, while used in high concentration of shorter treatment and lower concentration over longer period of treatment .…”

Section: Future Prospectsmentioning

confidence: 99%

“…Apart from mechanisms mentioned above, cellular senescence is another promising approach in anti-cancer therapy. 110 It has been reported that berberine, a natural product which shares similar structure with coptisine, induced apoptosis and premature senescence, respectively, while used in high concentration of shorter treatment and lower concentration over longer period of treatment. 111,112 Therefore, it will be meaningful to evaluate coptisine's effect on cellular senescence of cancer cells.…”

Section: Future Pros Pec Tsmentioning

confidence: 99%

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Coptisine fromCoptis chinensisexerts diverse beneficial properties: A concise review

Luo

Deng

et al. 2019

J Cellular Molecular Medi

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Coptisine is a natural small‐molecular compound extracted from Coptis chinensis (CC) with a history of using for thousands of years. This work aimed at summarizing coptisine's activity and providing advice for its clinical use. We analysed the online papers in the database of SciFinder, Web of Science, PubMed, Google scholar and CNKI by setting keywords as ‘coptisine’ in combination of ‘each pivotal pathway target’. Based on the existing literatures, we find (a) coptisine exerted potential to be an anti‐cancer, anti‐inflammatory, CAD ameliorating or anti‐bacterial drug through regulating the signalling transduction of pathways such as NF‐κB, MAPK, PI3K/Akt, NLRP3 inflammasome, RANKL/RANK and Beclin 1/Sirt1. However, we also (b) observe that the plasma concentration of coptisine demonstrates obvious non‐liner relationship with dosage, and even the highest dosage used in animal study actually cannot reach the minimum concentration level used in cell experiments owing to the poor absorption and low availability of coptisine. We conclude (a) further investigations can focus on coptisine's effect on caspase‐1‐involved inflammasome assembling and pyroptosis activation, as well as autophagy. (b) Under circumstance of promoting coptisine availability by pursuing nano‐ or microrods strategies or applying salt‐forming process to coptisine, can it be introduced to clinical trial.

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Section: Future Prospectsmentioning

confidence: 99%

Section: Future Pros Pec Tsmentioning

confidence: 99%

Coptisine fromCoptis chinensisexerts diverse beneficial properties: A concise review

Luo

Deng

et al. 2019

J Cellular Molecular Medi

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“…Antioxidants are found in the diet and natural products. Vitamin E, vitamin C (ascorbic acid), β-carotene and flavonoids are natural anti-oxidants [17][18][19]. Cancer is the leading cause of death in the world.…”

Section: Introductionmentioning

confidence: 99%

The antioxidation and antiproliferation activity of flavonoids from Aquilaria agallocha and Aquilaria sinensis

Liu¹,

Perng²,

Chen³

2018

biomedicalresearch

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Studies have shown that herbal extractions may be effective against various diseases like cancer and cardiovascular disease. In this study, we intended to evaluate the cytotoxicity and antioxidation activity of phytochemical constituents from the leaves of Aquilaria agallocha and the stems of Aquilaria sinensis.The chemical structures were identified by UV, IR, ESI-MS, 1H NMR and 13C NMR analyses. 5-hydroxy-7, 4'-dimethoxyflavone (1), 5, 3'-dihydroxy-7, 4'-dimethoxyflavone (2), 5-hydroxy-7, 3', 4'-trimethoxyflavone (3), 5, 7, 4′-trihydroxyflavone (4), and 3', 4', 5, 7-tetrahydroxyflavone (5) were isolated and further examined antioxidation and antiproliferation activity by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and MTT assay. According these results, 5-hydroxy-7, 3', 4'-trimethoxyflavone (3) had DPPH radical scavenging activity. Further, 5-hydroxy-7, 3', 4'-trimethoxyflavone (3) also showed significant positive anticancer activities (10-100 μM) against human skin cancer cell line A375 cells.

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“…Apigenin, a member of a non-mutagenic and less toxic [6] subclasses of flavone is found naturally in many plants. It has been reported [7] that apigenin is a powerful protein kinase C (PKC) inhibitor and antioxidant, with a range of pharmacological applications, many related to hyperlipidaemia [8] and hypertension [9].…”

Section: Introductionmentioning

confidence: 99%

Normal Vascular Reactivity Is Restored by Apigenin in Diabetic Rats

El-Bassossy

Desoky

Alahdal

et al. 2018

Int J Pharm Pharm Sci

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Objective: Diabetes is a disease whose complications have serious implications for the health of sufferers; one of the most serious such complications is the deterioration of vascular reactivity. Apigenin is a natural flavonoid with PKC inhibiting and antioxidant properties. In this study, the impact of apigenin on vascular reactivity deterioration was investigated.Methods: Insulin resistance (IR) and insulin deficiency (ID) were induced by fructose and streptozotocin respectively. The isolated aortae vasoconstriction response to phenylephrine (PE) and potassium chloride (KCl) in addition to the vasodilation response to acetylcholine (ACh) and sodium nitroprusside (SNP) were tested.Results: IR and ID were associated with significantly exaggerated vasoconstriction to KCl and PE while significantly impaired vasodilation to ACh. Response to SNP was not significantly affected by both IR and ID. In vitro incubation with apigenin (7 7µM) for 20 min restored normal responses to PE, KCl and ACh in aortae isolated from insulin-resistant or insulin-deficient rats. Incubation for one hour with the PKC stimulant, phorbol 12-myristate 13-acetate (PMA, 800 nM) resulted in aortic impairment similar to that seen in aortae isolated from IR and ID animals. Incubation with both apigenin prevented PMA-induced exaggerated vasoconstriction response to both PE and KCl.Conclusion: Apigenin alleviates vascular exaggerated vasoconstriction and impaired dilation associated with diabetes or PKC activated.

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Apigenin: A dietary flavonoid with diverse anticancer properties

Cited by 284 publications

References 107 publications

Coptisine fromCoptis chinensisexerts diverse beneficial properties: A concise review

Coptisine fromCoptis chinensisexerts diverse beneficial properties: A concise review

The antioxidation and antiproliferation activity of flavonoids from Aquilaria agallocha and Aquilaria sinensis

Normal Vascular Reactivity Is Restored by Apigenin in Diabetic Rats

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