The antioxidation and antiproliferation activity of flavonoids from Aquilaria agallocha and Aquilaria sinensis

Abstract

Studies have shown that herbal extractions may be effective against various diseases like cancer and cardiovascular disease. In this study, we intended to evaluate the cytotoxicity and antioxidation activity of phytochemical constituents from the leaves of Aquilaria agallocha and the stems of Aquilaria sinensis.The chemical structures were identified by UV, IR, ESI-MS, 1H NMR and 13C NMR analyses. 5-hydroxy-7, 4'-dimethoxyflavone (1), 5, 3'-dihydroxy-7, 4'-dimethoxyflavone (2), 5-hydroxy-7, 3', 4'-trimethoxyflavone (3), 5, 7, 4′-trihydroxyflavone (4), and 3', 4', 5, 7-tetrahydroxyflavone (5) were isolated and further examined antioxidation and antiproliferation activity by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and MTT assay. According these results, 5-hydroxy-7, 3', 4'-trimethoxyflavone (3) had DPPH radical scavenging activity. Further, 5-hydroxy-7, 3', 4'-trimethoxyflavone (3) also showed significant positive anticancer activities (10-100 μM) against human skin cancer cell line A375 cells.

A Review: Aquilaria Species as Potential of Pharmacological

“…This plant has various pharmacological activities. One of them was reported by Liu et al, (2018) [9] which evaluated the antioxidant activity and cytotoxicity of Aquilaria sinensis. Aquilaria sinensis stem samples were repeatedly extracted with MeOH.…”

“…This type of tree is found in many countries in the oriental region such as Indonesia, Malaysia, Thailand, India, Laos, and China [8]. In addition, Aquilaria extract has also been reported to have anticancer activity [9,11,14], antiinflammatory [1], antioxidant [3,9,14], and antidiabetic [14] which have been demonstrated in many in vivo and in vitro models. Therefore, the pharmacological effects of Aquilaria with different species and tree parts have different and similar pharmacological properties.…”

Comparative Analysis of Metabolome and Transcriptome in Different Tissue Sites of Aquilaria sinensis (Lour.) Gilg

“…These compounds mainly consist of sesquiterpenoids, 2-(2-phenethyl)chromonone, diterpenoids, triterpenoids, steroids, and aromatic agents [ 12 ]. Flavonoids were widely distributed in stems and leaves [ 13 , 14 , 15 ]. Benzophenones were primarily found in leaves, flowers, and pericarp, with a lesser distribution in stems [ 16 , 17 , 18 ].…”

Cytotoxic Activity of Ethanolic Extract Aquilaria malaccensis Leaves Against MCF-7 Cells

“…Recent studies suggest that secondary metabolites from Aquilaria species, which belong to the Thymelaeaceae family, have the potential to inhibit tumourigenesis by identifying the plant-derived compounds as anticancer agents (4). Various studies have revealed that the leaves of Aquilaria species have promising potential for agricultural and pharmaceutical industries due to their diverse biological activities such as antimicrobial (5), antifungal (6), antioxidant (5,7), antinociceptive (8), antiinflammatory (9-10), antidiabetic (11)(12) and anticancer (5,(13)(14) agents. Although some studies indicated that secondary metabolites of Aquilaria species could be used to treat cancer (7,15), there is still no scientific evidence on the effectiveness of A. malaccensis leaves as a treatment for breast cancer.…”

“…Various studies have revealed that the leaves of Aquilaria species have promising potential for agricultural and pharmaceutical industries due to their diverse biological activities such as antimicrobial (5), antifungal (6), antioxidant (5,7), antinociceptive (8), antiinflammatory (9-10), antidiabetic (11)(12) and anticancer (5,(13)(14) agents. Although some studies indicated that secondary metabolites of Aquilaria species could be used to treat cancer (7,15), there is still no scientific evidence on the effectiveness of A. malaccensis leaves as a treatment for breast cancer. The goal of this research was to determine the results of A. malaccensis ethanolic extract in terms of cytotoxicity, antiproliferative effect and apoptosis induction on human breast MCF-7 cell line.…”