Apicidin-Resistant HA22T Hepatocellular Carcinoma Cells strongly activated the Wnt/β-Catenin Signaling Pathway and MMP-2 Expression via the IGF-IR/PI3K/Akt Signaling Pathway Enhancing Cell Metastatic Effect

Hsieh, Cheng Hong; Cheng, Li; Hsu, Hsi Hsien; Ho, Tsung Jung; Tu, Chuan Chou; Chen, Ming Cheng; Tsai, Fuu Jen; Hsieh, You Liang; Huang, Chih Yang

doi:10.1271/bbb.130503

Cited by 25 publications

(21 citation statements)

References 85 publications

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“…These results indicate that the MMPs contribute to the tumor-promoting effects of ADSCs in vitro and in vivo. Several signaling pathways were thought to be able to regulate the expression of MMPs in cancer cells, such as Hedgehog, Wnt, PI3 Kinase/Akt and NF-κB [31][32][33][34]. However, precise mechanisms involved in the elevated MMPs in tumor cells mediated by MSCs remain elusive.…”

Section: Discussionmentioning

confidence: 99%

Adipose-derived mesenchymal stem cells promote cell proliferation and invasion of epithelial ovarian cancer

Chu

Tang

Guo

et al. 2015

Experimental Cell Research

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Section: Discussionmentioning

confidence: 99%

Adipose-derived mesenchymal stem cells promote cell proliferation and invasion of epithelial ovarian cancer

Chu

Tang

Guo

et al. 2015

Experimental Cell Research

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“…Numerous cell signaling pathways are critical in the regulation of MMPs (4,17,23,24). For example, the AKT signaling pathway is associated with the expression of MMP-2/-9 in healthy and cancerous tissues (24,25).…”

Section: Discussionmentioning

confidence: 99%

Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway

2015

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Abstract. The anticancer effect of baicalein has been known for a number of years. However, its anti-metastatic effect and associated mechanisms in colorectal cancer (CRC) remain unclear. The present study investigated the hypothesis that treatment with baicalein may inhibit the proliferation, motility and invasion of human CRC cell lines via regulation of the protein kinase B (AKT) signaling pathway. Baicalein was demonstrated to significantly inhibit the migration and invasion of CRC cells (P=0.01). Additionally, after treatment with baicalein for 24 h, the protein expression levels of matrix metalloproteinase-2 (MMP-2) and MMP-9 in CRC cells were significantly reduced in a dose-dependent manner (P=0.01). Furthermore, treatment with baicalein significantly reduced the expression levels of phosphorylated AKT (P=0.01). In conclusion, baicalein appears to inhibit CRC cell migration and invasion by reducing the expression of MMP-2 and MMP-9 via suppression of the AKT signaling pathway. Thus, baicalein is a potential novel therapeutic agent for patients with CRC.

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“…Therefore, AKT inhibits Bcl2 antagonist of cell death (BAD) that, together with the contemporary activation of mouse double minute 2 (MDM2), prevents apoptosis. In some tumors, but not in ACTs, AKT inhibits the glycogen synthase kinase‐3β (GSK‐3β) phosphorylation of β‐catenin leading to a stabilization of β‐catenin which translocates into the nucleus and stimulates the transcription of Wnt target genes . Unlike IGF‐1R, the activation of IR signaling via the PI3K pathway is also a key factor in the translocation of GLUT‐4 glucose transporters to the cell membrane, thereby leading to increased glucose uptake .…”

Section: Insulin/igf System Signaling Pathwaymentioning

confidence: 99%

Adrenocortical tumors and insulin resistance: What is the first step?

Altieri¹,

Tirabassi

Casa³

et al. 2015

Intl Journal of Cancer

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The pathogenetic mechanisms underlying the onset of adrenocortical tumors (ACTs) are still largely unknown. Recently, more attention has been paid to the role of insulin and insulin-like growth factor (IGF) system on general tumor development and progression. Increased levels of insulin, IGF-1 and IGF-2 are associated with tumor cell growth and increased risk of cancer promotion and progression in patients with type 2 diabetes. Insulin resistance and compensatory hyperinsulinemia may play a role in adrenal tumor growth through the activation of insulin and IGF-1 receptors. Interestingly, apparently non-functioning ACTs are often associated with a high prevalence of insulin resistance and metabolic syndrome. However, it is unclear if ACT develops from a primary insulin resistance and compensatory hyperinsulinemia or if insulin resistance is only secondary to the slight cortisol hypersecretion by ACT. The aim of this review is to summarize the current evidence regarding the relationship between hyperinsulinemia and adrenocortical tumors.

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Apicidin-Resistant HA22T Hepatocellular Carcinoma Cells strongly activated the Wnt/β-Catenin Signaling Pathway and MMP-2 Expression via the IGF-IR/PI3K/Akt Signaling Pathway Enhancing Cell Metastatic Effect

Cited by 25 publications

References 85 publications

Adipose-derived mesenchymal stem cells promote cell proliferation and invasion of epithelial ovarian cancer

Adipose-derived mesenchymal stem cells promote cell proliferation and invasion of epithelial ovarian cancer

Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway

Adrenocortical tumors and insulin resistance: What is the first step?

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