Adipose-derived mesenchymal stem cells promote cell proliferation and invasion of epithelial ovarian cancer

Chu, Yijing; Tang, Huijuan; Guo, Yan; Guo, Jing; Huang, Bangxing; Fang, Fang; Cai, Jing; Wang, Zehua

doi:10.1016/j.yexcr.2015.07.020

Cited by 69 publications

(66 citation statements)

References 37 publications

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“…However, there are some concerns about the potential risk of MSCs. Some researches showed that human MSCs favored the survival and progression of cancer cells through promoting cell proliferation, enhancing invasion/metastasis40, and inducing neovascularization41. Lalu et al .…”

Section: Discussionmentioning

confidence: 99%

Human endometrial mesenchymal stem cells exhibit intrinsic anti-tumor properties on human epithelial ovarian cancer cells

Wang

Zhang

et al. 2016

Sci Rep

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Epithelial ovarian cancer (EOC) is the most lethal tumor of all gynecologic tumors. There is no curative therapy for EOC thus far. The tumor-homing ability of adult mesenchymal stem cells (MSCs) provide the promising potential to use them as vehicles to transport therapeutic agents to the site of tumor. Meanwhile, studies have showed the intrinsic anti-tumor properties of MSCs against various kinds of cancer, including epithelial ovarian cancer. Human endometrial mesenchymal stem cells (EnSCs) derived from menstrual blood are a novel source for adult MSCs and exert restorative function in some diseases. Whether EnSCs endow innate anti-tumor properties on EOC cells has never been reported. By using tumor-bearing animal model and ex vivo experiments, we found that EnSCs attenuated tumor growth by inducing cell cycle arrest, promoting apoptosis, disturbing mitochondria membrane potential and decreasing pro-angiogenic ability in EOC cells in vitro and/or in vivo. Furthermore, EnSCs decreased AKT phosphorylation and promoted nuclear translocation of Forkhead box O-3a (FoxO3a) in EOC cells. Collectively, our findings elucidated the potential intrinsic anti-tumor properties of EnSCs on EOC cells in vivo and in vitro. This research provides a potential strategy for EnSC-based anti-cancer therapy against epithelial ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Human endometrial mesenchymal stem cells exhibit intrinsic anti-tumor properties on human epithelial ovarian cancer cells

Wang

Zhang

et al. 2016

Sci Rep

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“…They promote cell proliferation and invasion of human epithelial ovarian cancer cell lines (SKOV3, CAOV3, A2780 and ES2) 38. Both AT-MSCs and BM-MSCs promote vascularization and growth of endometrial tumors 39.…”

Section: Mscs In Anticancer Therapiesmentioning

confidence: 99%

Human-derived normal mesenchymal stem/stromal cells in anticancer therapies

Zhang¹,

Yang²,

Qin³

et al. 2017

J. Cancer

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The tumor microenvironment (TME) not only plays a pivotal role during cancer progression and metastasis, but also has profound effects on therapeutic efficacy. Stromal cells of the TME are increasingly becoming a key consideration in the development of active anticancer therapeutics. However, dispute concerning the role of stromal cells to fight cancer continues because the use of mesenchymal stem/stromal cells (MSCs) as an anticancer agent is dependent on the specific MSCs subtype, in vitro or in vivo conditions, factors secreted by MSCs, types of cancer cell lines and interactions between MSCs, cancer cells and host immune cells. In this review, we mainly focus on the role of human-derived normal MSCs in anticancer therapies. We first discuss the use of different MSCs in the therapies for various cancers. We then focus on their anticancer mechanism and clinical application.

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“…MSCs are recruited to the primary tumor site from the bone marrow in response to tumor derived soluble factors to promote cancer progression through mechanisms that involve cytokines and collagen deposition (Berger et al, 2015; El-Haibi et al, 2012; Kalluri and Zeisberg, 2006; Karnoub et al, 2007; Liu et al, 2011; Madar et al, 2013). Likewise, adipose-derived MSCs have been shown to enhance tumor volume of MDA-MB-231 xenografts and to promote cell proliferation and invasion of ovarian cancer (Chu et al, 2015; Millet et al, 2016). However, the underlying mechanisms of MSC function need further investigation.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth

et al. 2017

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Summary Increased collagen deposition by breast cancer (BC)-associated mesenchymal stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are unknown. Here, we report that the collagen receptor Discoidin Domain Receptor 2 (DDR2) is essential for stromal-BC communication. In human BC metastasis DDR2 is concordantly upregulated in metastatic cancer and multipotent mesenchymal stromal cells. In MSCs isolated from human BC metastasis DDR2 maintains a fibroblastic phenotype with collagen deposition and induces pathological activation of DDR2 signaling in BC cells. Loss of DDR2 in MSCs impairs their ability to promote DDR2 phosphorylation in BC cells, BC cell alignment, migration, and metastasis. Female ddr2-deficient mice homozygous for the slie mutation show inefficient spontaneous BC metastasis. These results document a role for mesenchymal stem cell DDR2 in metastasis, and suggest a therapeutic approach for metastatic BC.

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Adipose-derived mesenchymal stem cells promote cell proliferation and invasion of epithelial ovarian cancer

Cited by 69 publications

References 37 publications

Human endometrial mesenchymal stem cells exhibit intrinsic anti-tumor properties on human epithelial ovarian cancer cells

Human endometrial mesenchymal stem cells exhibit intrinsic anti-tumor properties on human epithelial ovarian cancer cells

Human-derived normal mesenchymal stem/stromal cells in anticancer therapies

Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth

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