Apical periodontitis induced by selected bacterial strains in root canals of immunized and nonimmunized monkeys

Dahlén, Gunnar; Fabrigius, Lars; Heyden, G; Holm, Stig E.; Möller, Å.

doi:10.1111/j.1600-0722.1982.tb00729.x

Cited by 30 publications

(35 citation statements)

References 21 publications

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“…Bacteria cause periodontal disease as well as apical periodontitis (20–23), but other factors may determine the severity of the disease and how a specific patient responds to therapy or pathogenic bacteria (24). Bacteria are still required to initiate the patient’s inflammatory response, but other factors can modulate or amplify that inflammatory response to change the clinical presentation and the progression of disease (25–28).…”

Section: Discussionmentioning

confidence: 99%

Genetic Predisposition to Persistent Apical Periodontitis

Morsani

Aminoshariae

Han

et al. 2011

Journal of Endodontics

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Introduction The proinflammatory cytokine interleukin (IL)-1 is a key regulator of host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption. Allele2 of IL-1b is associated with a four-fold increase in IL-1β production. The aim of this case-control study was to evaluate the gene polymorphism of IL-1β in the pathogenesis of endodontic failure. We hypothesized that the gene polymorphism (allele2 of IL-1β) would influence host response and enhance inflammatory reactions predisposing to persistent apical periodontitis (PAP). Materials and Methods Subjects with at least 1 year of follow-up after root canal therapy (RCT) were recalled. Inclusion and exclusion criteria were applied, and 34 subjects with signs/symptoms of PAP with otherwise acceptable RCT were included. Sixty-one controls showed healing with acceptable RCT. Genomic DNA from buccal mucosa was amplified by polymerase chain reaction followed by restriction fragment length polymorphism to distinguish the alleles of IL-1β gene polymorphism. Results A significant difference in the distribution of the polymorphic genotype among cases (70.6%) and controls (24.6%) (P < .001, Pearson χ2) was shown. Conclusions These findings suggest that specific genetic markers associated with increased IL-1β production may contribute to increased susceptibility to PAP.

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Section: Discussionmentioning

confidence: 99%

Genetic Predisposition to Persistent Apical Periodontitis

Morsani

Aminoshariae

Han

et al. 2011

Journal of Endodontics

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“…[1][2][3][4] Infections within the root canal system of a tooth cause periapical inflammatory responses which usually manifest as periapical radiolucencies and occasionally as radiopacities on radiographs. 2,4 Bacteria also play a major role in the *School of Dentistry, The University of Western Australia.…”

Section: Introductionmentioning

confidence: 99%

The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics

Athanassiadis

Abbott

Walsh

2007

Australian Dental Journal

285

269

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Bacteria have been implicated in the pathogenesis and progression of pulp and periapical diseases. The primary aim of endodontic treatment is to remove as many bacteria as possible from the root canal system and then to create an environment in which any remaining organisms cannot survive. This can only be achieved through the use of a combination of aseptic treatment techniques, chemomechanical preparation of the root canal, antimicrobial irrigating solutions and intracanal medicaments. The choice of which intracanal medicament to use is dependent on having an accurate diagnosis of the condition being treated, as well as a thorough knowledge of the type of organisms likely to be involved and their mechanisms of growth and survival. Since the disease is likely to have been caused by the presence of bacteria within the root canal, the use of an antimicrobial agent is essential. Many medicaments have been used in an attempt to achieve the above aims but no single preparation has been found to be completely predictable or effective. Commonly used medicaments include calcium hydroxide, antibiotics, non-phenolic biocides, phenolic biocides and iodine compounds. Each has advantages and disadvantages, and further research is required to determine which is best suited for root canal infections.Key words: Endodontics, bacteria, antimicrobial, medicaments.Abbreviations and acronyms: Ca(OH) 2 = calcium hydroxide; CFU = colony forming units; CHX = chlorhexidine; CMP = camphorated monochlorophenol; CP = camphorated phenol; IPI = iodine potassium iodide; LPS = lipopolysaccharide; NaOCI = sodium hypochlorite; PEG = polyethyleneglycol; PMCP = paramonochlorophenol; QAC = quaternary ammonium compounds.

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“…A compromised immune response may be unable to mount an effective defense response and allow direct penetration and invasion by bacteria into the host (124). A compromised immune response may be unable to mount an effective defense response and allow direct penetration and invasion by bacteria into the host (124).…”

Section: Other Pre-operative Clinical Signs and Symptomsmentioning

confidence: 99%

Outcome of non‐surgical re‐treatment

Ng¹,

Gulabivala²

2008

Endodontic Topics

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The purpose of this review was to critically analyze the relevant literature in order to synthesize an overview on the clinical outcomes (radiographically judged periapical healing and tooth survival) following root canal re‐treatment and the factors influencing them. A further aim was to explain the findings on the basis of current knowledge and understanding. The relevant literature was captured and critiqued using the principles of a systematic review. The data were classified into a coherent structure for analyses and presentation but are not presented as a systematic review; rather, the authors have chosen a narrative style to enable integration of the clinical outcomes with relevant findings from laboratory and animal studies. Overall, the outcomes were similar to those for teeth undergoing primary treatment with common factors influencing the outcomes. The major differences between the outcomes of primary and secondary root canal (re‐)treatment reside only in the ability to predictably access and negotiate the root canal system to the (residual) apical infection. The data offer a very favorable prognosis for non‐surgical root canal re‐treatment performed to guideline standards.

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Apical periodontitis induced by selected bacterial strains in root canals of immunized and nonimmunized monkeys

Cited by 30 publications

References 21 publications

Genetic Predisposition to Persistent Apical Periodontitis

Genetic Predisposition to Persistent Apical Periodontitis

The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics

Outcome of non‐surgical re‐treatment

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