Aphthous ulcerations

Scully, Crispian; Gorsky, Meir; Lozada‐Nur, Francina

doi:10.1046/j.1529-8019.2002.01528.x

Cited by 29 publications

(44 citation statements)

References 195 publications

(232 reference statements)

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“…The immune response in the RAS lesions and the nature of the cytokine profile indicates a T‐helper type I immune response. Especially, the increment in the expression of TNF‐α, IL‐2 and IFN‐γ and the decrement in the expression of IL‐4, IL‐5 and IL‐10 readily support this hypothesis 1 . Keratinocytes secrete cytokines such as IL and TNF‐α, which activate T cells.…”

Section: Discussionmentioning

confidence: 66%

Thyroid autoimmunity associated with recurrent aphthous stomatitis

Ozdemir

Çalka

Karadag

et al. 2011

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 66%

Thyroid autoimmunity associated with recurrent aphthous stomatitis

Ozdemir

Çalka

Karadag

et al. 2011

Acad Dermatol Venereol

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“…This preventive effect of smoking is associated with oral mucosal keratinization, which is seen in smokers, and antiinflammatory effect of nicotine (15,16). Only 8.2% of the patients in our study were smoker.…”

Section: Figure1 Minor Aphthaementioning

confidence: 50%

A Retrospective Evaluation of Patients with Recurrent Aphthous Stomatitis

Demir¹,

Demır²,

Türkoğlu³

et al. 2017

Haseki

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Aim:To determine the factors in the etiology of recurrent aphthous stomatitis (RAS) and to evaluate patients in the terms of RAS associated systemic disorders especially Behçet's disease. Methods:Patients with RAS, who were followed up in Bartın State Hospital Dermatology Clinic between July 2013 and April 2015, were retrospectively evaluated.Results: A total of 123 patients (86 female, 37 male) were included in this study. Thirteen (106%) patients were children. The mean age of patients was 34.5±14.7 years (range: 8-69 years). Minor aphthous somatitis was the most frequent clinical type (68.3%). Family history was positive in 52.8% of patients. The triggering factors in the etiology of RAS were stress (54.5%), trauma (40.2%), gingivitis (29.3%), food (9.8%), medicines (5.7%), menstruation in female patients (3.3%), and throat infections (2.4%). Nutritional deficiencies were found in 39% of patients. There was a statistically significant difference in attack frequency (p=0.017) and throat infection history (p=0.029) between adults and pediatric patients. Fourteen (11.4%) patients were diagnosed with Behçet's disease. When we compared the RAS patients diagnosed with Behçet's disease and the other RAS patients, a significant difference was found in pathergy test (p<0.001) and ferritin levels (p=0.020).Conclusion:Patients with RAS should be followed up for a long time for systemic disorders, especially for Behçet's disease, accompanying RAS. RAS'li çocuk hastalar ile erişkin hastaları karşılaştırdığımızda atak sıklığı ve boğaz enfeksiyonu (p=0,029) dışında istatistiksel açıdan anlamlı bir fark gözlenmedi. On dört hastaya (%11,4) Behçet hastalığı tanısı konuldu. Behçet hastalığı tanısı alan hastalar ile diğer RAS'li hastaları kıyasladığımızda, paterji pozitifliği (p<0,001) ve ferritin düzeyleri (p=0,020) arasındaki fark istatiksel açıdan anlamlıydı.Sonuç: RAS hastalarını sadece etiyolojik faktörler ve hematinik eksikler açısından değerlendirmek yeterli değildir. Bu hastalar başta Behçet hastalığı başta olmak üzere RAS'nin eşlik ettiği diğer sistemik hastalıklar açısından uzun süre takibe alınmalıdır.

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“…Topical steroids in the form of dental paste and gels (oral base) are used in the treatment of oral lesions of oral lichen planus [18], aphthous stomatitis [19], desquamative gingivitis and blistering disorders affecting the bucal cavity. Likewise, topical steroids are used equally in the treatment of eye diseases, such as keratitis and allergic conjunctivitis [20,21].…”

Section: Box 1 Classification Of Topical Steroids According To Theirmentioning

confidence: 99%

Misuse and abuse of topical steroids: implications

Nnoruka¹,

Daramola²,

Ike³

2007

Expert Review of Dermatology

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Topical steroids, having revolutionized dermatotherapy over several decades, remain the mainstay of treatment for steroid-responsive inflammatory dermatoses worldwide. Challenges, nevertheless, abound on the usage of topical steroids, particularly with their inappropriate application. Several steps and improved formulations are constantly evolving in the scientific world, aimed at addressing most of the associated adverse events. However, until the dawn of the 'ideal topical steroid', the implications of application misuse will remain significant. This review discusses the concept of 'misuse and abuse' of topical steroids, gives an overview of topical steroids, differentiates 'misuse' as opposed to 'abuse' of application of topical steroids as they occur in different settings and provides a schematic algorithm for the appropriate and optimal application of topical steroids. Consequently, this separation will allow a more accurate estimation of the burdens of these two aspects that require different solutions. 31-40 (2007) Topical glucocorticoids are the foundation of dermatotherapeutics [1], particularly for the noninfected inflammatory dermatoses, such as the eczemas and dermatitis. Their availability since 1952 has marked the most important milestone in dermatology to date [2,3]. Although the 'ideal' topical steroids have not yet been synthesized, topical administration of steroids still remains the safest mode of administration for glucocorticoids.Topical steroids are derivatives of the prototype hydrocortisone, a natural glucocortico steriod of the adrenal cortex. Chemical substitutions at certain key positions of the cyclopentanophenathrene nucleus, altering both its glucocorticoid and mineralocorticoid properties, affects the potency of these drugs. For example, halogenation at the 9-α position enhances the potency by improving activity within the target cell and decreasing breakdown into inactive metabolites [4], while masking or removing the hydrophilic 17-dihydroxyacetone side chain or the 16 α-hydroxy group increases the lipophilicity of the molecule, thereby enhancing penetration through the stratum corneum [1,5].The existence of a reservoir within the stratum corneum for most topical xenobiotics, particularly topical steroids [6,7], affects the choice of application frequency and the dose, while percutaneous absorption is dependent on the intrinsic property of the steroid, the vehicle used, the anatomical site, age of patient and method of application (i.e., under occlusion or hydration). However, individual variation in percutaneous absorption can also be quite pronounced. All of these factors must be taken into account when considering the potential for undesirable effects of topical steroids.Abuse of steroids could be regarded as the use of steroids to achieve purposes other than a therapeutic one, while misuse of steroids can be regarded as the inappropriate use of steroids for therapeutic purposes. These terms are introduced in this article for the purpose of describing the inapt use of prescr...

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Aphthous ulcerations

Cited by 29 publications

References 195 publications

Thyroid autoimmunity associated with recurrent aphthous stomatitis

Thyroid autoimmunity associated with recurrent aphthous stomatitis

A Retrospective Evaluation of Patients with Recurrent Aphthous Stomatitis

Misuse and abuse of topical steroids: implications

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