Aphthous stomatitis (canker sores): A consequence of high oral submucosal viscosity (the role of extracellular matrix and the possible role of lectins)

Stone, Orville J.

doi:10.1016/0306-9877(91)90007-l

Cited by 21 publications

(9 citation statements)

References 18 publications

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“…Trauma predisposes to RAS by inducing edema and early cellular inflammation associated with an increased viscosity of the oral submucosal extracellular matrix 12 . Not all oral trauma leads to RAS, because denture wearers do not have a high prevalence of RAS in spite of the fact that this cohort is three times more susceptible to oral mucosal ulceration 13 .…”

Section: Predisposing Etiologic Factorsmentioning

confidence: 99%

Recurrent Aphthous Stomatitis

Akintoye

Greenberg

2014

Dental Clinics of North America

264

216

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Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative disease affecting the oral mucosa. It occurs mostly in healthy individuals and has atypical clinical presentation in immunocompromised individuals. The etiology of RAS is still unknown, but several local, systemic, immunologic, genetic, allergic, nutritional, and microbial factors, as well as immunosuppressive drugs, have been proposed as causative agents. Clinical management of RAS is based on severity of symptoms, frequency, size and number of lesions using topical and systemic therapies. The goals of therapy are to decrease pain and ulcer size, promote healing and decrease frequency of recurrence.

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Section: Predisposing Etiologic Factorsmentioning

confidence: 99%

Recurrent Aphthous Stomatitis

Akintoye

Greenberg

2014

Dental Clinics of North America

264

216

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“…Local trauma is regarded as a causative agent for RAS in susceptible individuals, and RAS are uncommon where mucosal keratinization is present or in patients who smoke tobacco (2). Trauma predisposes to RAS by inducing edema, early cellular inflammation associated with an increased viscosity of the oral submucosal extracellular matrix (9). Not all oral trauma lead to RAS, because denture wearers are usually three times more susceptible to oral mucosal ulceration, but RAS is not the most prevalent ulceration in this cohort (10).…”

Section: Epidemiologymentioning

confidence: 99%

Recurrent aphthous stomatitis: a review

Chavan

Jain

Diwan

et al. 2012

J Oral Pathology Medicine

272

192

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J Oral Pathol Med (2012) 41: 577–583 Recurrent aphthous stomatitis (RAS) is a common clinical condition producing painful ulcerations in oral cavity. The diagnosis of RAS is based on well‐defined clinical characteristics but the precise etiology and pathogenesis of RAS remain unclear. The present article provides a detailed review of the current concepts and knowledge of the etiology, pathogenesis, and management of RAS.

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“…They may occur singly as aphthous stomatitis lesions or in groups as recurrent aphthous stomatitis (RAS) 1,2. The histopathology of the ulcerated lesions is similar to that which occurs under sites of acute inflammation of the skin 3. The canker sore is most painful during the first 3–4 days.…”

Section: Introductionmentioning

confidence: 64%

“…The canker sore is most painful during the first 3–4 days. The discomfort gradually diminishes and the sore heals in 10–14 days, usually without scarring 3–5. Before it becomes visible, the canker sore may produce a tingling or burning sensation.…”

Section: Introductionmentioning

confidence: 99%