Aphrodisiac and phytochemical studies of Cocculus hirsutus extracts in albino rats

Patil, Sharanabasappa A; Sujaya, M; Patil, Saraswati B.

doi:10.1016/s2305-0500(13)60180-3

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…Testosterone values of the Diplotaenia turcica root extract (100 and 200 mg/kg) groups were significantly higher than those of the diabetes and diabetes + Diplotaenia turcica root extract groups (p < 0.001). This outcome presented parallels with studies indicating an increase in testosterone levels in diabetic groups due to the administration of a number of extracts such as Mucuna pruriens, Cocculus hirsutus, and Kaempferia parviflora, which were acknowledged as antidiabetics (Lert-Amornpat et al, 2017;Patil et al, 2014;Suresh and Prakash, 2012). The results of this study suggest this supplement could provide an androgenic effect, as Diplotaenia turcica root extract particularly and significantly increases serum testosterone levels in STZ-induced diabetic rats.The literature review did not indicate a similar study that focuses on the use of Diplotaenia turcica root extract in diabetic rats.…”

Section: Discussionsupporting

confidence: 85%

The Effects of Diplotaenia Turcica Root Extract on Sperm Parameters and Reproductive Hormones in Streptozotocin Induced Diabetic Rats

Belhan

Değer

Huyut

et al. 2020

Harran Üniversitesi Veteriner Fakültesi Dergisi

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This study was conducted to determine the effects of Diplotaenia turcica root extract on sperm parameters and reproductive hormones in streptozotocin (STZ) induced diabetic rats. The study was performed on a total of 42 male rats divided into 6 groups of equal numbers. Single-dose physiological saline was administrated intraperitoneally to Group 1. STZ 45 mg/kg was administered intraperitoneally to Group 2. Diplotaenia turcica root extract 100 mg/kg was administrated through gastric gavage for 28 days to Group 3. Diplotaenia turcica root extract 200 mg/kg was administrated through gastric gavage for 28 days to Group 4. STZ 45 mg/kg administrated intraperitoneally to Group 5. In addition, Diplotaenia turcica root extract 100 mg/kg was administrated through gastric gavage for 28 days. STZ 45 mg/kg administrated intraperitoneally to Group 6. Also, Diplotaenia turcica root extract 200 mg/kg was administrated through gastric gavage for 28 days. Reproductive hormones and sperm parameters were analyzed. In Group 2, it was determined that sperm motility and density and reproductive hormone values were significantly lower when compared to group 1, and the abnormal sperm rate was significantly higher when compared to Group 1. Testosterone levels in Groups 3 and 4 were significantly higher than Groups 2, 5, and 6. It was determined that the 100 mg/kg dose of Diplotaenia turcica root extract, which is given also to the diabetic group, creates an improvement in sperm parameters and the hormone testosterone, but the 200 mg/kg dose does not have the same effect. As a result, we can recommend the 100 mg/kg dose of Diplotaenia turcica root extract in patients with diabetes.

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Section: Discussionsupporting

confidence: 85%

The Effects of Diplotaenia Turcica Root Extract on Sperm Parameters and Reproductive Hormones in Streptozotocin Induced Diabetic Rats

Belhan

Değer

Huyut

et al. 2020

Harran Üniversitesi Veteriner Fakültesi Dergisi

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“…Testicular dysfunction, due to either endogenous or exogenous factors, may result in a decline in male sexual activeness, androgen synthesis, and fertility. An increasing body of evidence supports the use of medicinal plants, parts or whole plant, in the management of testicular dysfunctions [ 8 – 10 ]. In this study, effect of the methanolic roots extracts of M. procumbens and O. paniculosa in butanol-induced testicular dysfunction in male rats is reported.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, therapeutic effect of a number of medicinal plants against testicular dysfunction has also been associated with their antioxidant activities [ 10 ]. The high content of polyunsaturated fatty acids and the presence of potential ROS system in the testes render them highly vulnerable to oxidative stress [ 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Despite an increasing number of men's health clinics worldwide and the use of pharmaceutical agents to manage complications of testicular dysfunction, substantial number of men, particularly living in rural areas, continue to consult traditional healers to improve their sexual functioning [ 7 ]. The use of medicinal plants, by traditional healers against sexual dysfunctions, has a long and extensive history [ 8 – 10 ]. Ethnopharmacological survey of traditional healers in Northern Kwa-Zulu Natal (South Africa) indicates that powdered roots of Maytenus procumbens and Ozoroa paniculosa are commonly used by traditional healers in the management of testicular dysfunctions (Personal communication).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Testicular Dysfunction Ameliorative Effect of the Methanolic Roots Extracts of Maytenus procumbens and Ozoroa paniculosa

Cele

Sangweni

Mosa

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The traditional use of medicinal plants in the management of sexual dysfunctions has a long history. This study investigated testicular dysfunction ameliorative effect of the methanolic roots extracts of Maytenus procumbens and Ozoroa paniculosa in a butanol-induced testicular dysfunction rat model. The rats in respective experimental groups were orally administered with the extract at 50 and 250 mg/kg bw, daily for 28 days. The cytotoxicity of the extracts was evaluated against HEK293, MCF-7, and HT29 cell lines. The extracts exhibited moderate (LC50 30.3–330.2 μg/mL) to weak (LC50 200.8–438.4 μg/mL) cytotoxicity level on the cancer and normal cells, respectively. While relatively lower serum testosterone levels and total sperm count along with decreased numbers of spermatogonia were noted in the untreated group, all these parameters were improved in the groups treated with the extracts at 250 mg/kg. Improved histomorphological changes of the testes were also observed when compared to the untreated group. While the extracts (at 250 mg/kg) increased serum reduced glutathione content and decreased malondialdehyde content, a relatively higher serum creatinine level was also observed in the treated animals group. The results indicate that the two plant extracts have potential to ameliorate testicular dysfunction.

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“…After subjecting to preliminary phytochemical screening, the alcohol extract showed positive tests for steroids, saponins, oils and fats, phenolic compounds and tannins. (Patil et al 2014) [47] Inference can be drawn that this therapy aims to improve the function of the reproductive organs and vitalizes reproductive tissues increasing semen count and strengthening sperm motility in men and making eggs more viable for conception in women. After thorough understanding of the concept of Vrishya and Vajikarana, the specific drugs being used for this aphrodisiac treatment need to be analyzed further on the basis of seminal parameters, quality of sexual life and the pharmacodynamic and kinetic study.…”

Section: (Suresh S Et Al 2009) [42]mentioning

confidence: 99%

Vrishya and Vajikarana - Exploring Ancient Science of Aphrodisiacs

Chaudhary¹,

Lamba²,

Mehra³

2017

J Res Educ Indian Med - ISSN 0970-7700

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Introduction:Vajikarana is one of the eight specialities of Ashtang Ayurveda dealing with the management of pathophysiology of spermatogenesis and healthy sexual potentiation. This aphrodisiac therapy is advocated for various sexual and reproductive disease i.e., Klaibya or Erectile dysfunctions, Bandhyatva or Infertility, Shukraghata Vata or azospermia and premature ejaculation. Vrishya, a synonym of Vajikara, is the technical term indicating spermatogenic and aphrodisiac effect of a dravya (foods, herbs, spices and Medicinal plants) including audio-visual, socio-religious effects/ sexual behaviour factors/ constants). Currently, the importance of this branch has increased manifold, as more and more people are reporting to clinics with various disorders related to seminal parameters and sexual dysfunction. Material and Methods: Various drugs mentioned under these therapies were searched including scientific data pertaining to their efficacy and probable mode of action. The search was limited to Ayurveda classics, books and published works from pubmed as well as non-pubmed indexed journals including google scholar database. The present review is mainly focussed on brihatryi (Charaka Samhita, Sushruta Samhita and Ashtang) for elaborate understanding of the concept of Vrishya and Vajikarana. The texts Sarangdhar Samhita and Bhavprakash Nighantu were searched for the drugs indicated as vrishya and vajikarana properties. Results: Analyses of the textual data revealed that Vrishya dravyas act as Vajikara also, but all Vajikara dravyas do not possess Vrishya property. This appears due to predominance of stimulant action on Sukravaha Samsthana in Vajikara dravyas while Vrishya has mainly quantitative and qualitative effect on Sukra. These drugs also act on higher centres of the brain which helps to alleviate anxiety associated with sexual performance as revealed by the published scientific data. Aphrodiasics also modulate the level of the pituitary hormones FSH and LH. The drugs possessing these properties have been tabulated in the text. Conclusion: Vajikarana is the therapy while Vrishya is the property (Karma) of the drug. Vrishya drugs are successful in treating conditions of reproductive disorders and sexual performance and they have an effect on pituitary-gonadal axis. Investigations in validation of these drugs will go a long way in management of infertility.

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Aphrodisiac and phytochemical studies of Cocculus hirsutus extracts in albino rats

Cited by 9 publications

References 11 publications

The Effects of Diplotaenia Turcica Root Extract on Sperm Parameters and Reproductive Hormones in Streptozotocin Induced Diabetic Rats

The Effects of Diplotaenia Turcica Root Extract on Sperm Parameters and Reproductive Hormones in Streptozotocin Induced Diabetic Rats

Testicular Dysfunction Ameliorative Effect of the Methanolic Roots Extracts of Maytenus procumbens and Ozoroa paniculosa

Vrishya and Vajikarana - Exploring Ancient Science of Aphrodisiacs

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