1997
DOI: 10.1002/(sici)1096-9896(199704)181:4<426::aid-path768>3.0.co;2-t
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Apc Expression in Normal Human Tissues

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Cited by 90 publications
(40 citation statements)
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References 38 publications
(40 reference statements)
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“…Moreover, and catenin, as well as E-cadherin, are known to be associated with the APC tumour suppressor gene; this association is stronger and more specific than similar associations in any other type of sporadic epithelial tumour. 24 Most of the mutations in APC result in truncated APC protein, which can complex with but not degrade catenin. The net result of APC mutation is an increase in cytoplasmic catenin, which may then trigger a cascade of events resulting in the initiation of adenomas.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, and catenin, as well as E-cadherin, are known to be associated with the APC tumour suppressor gene; this association is stronger and more specific than similar associations in any other type of sporadic epithelial tumour. 24 Most of the mutations in APC result in truncated APC protein, which can complex with but not degrade catenin. The net result of APC mutation is an increase in cytoplasmic catenin, which may then trigger a cascade of events resulting in the initiation of adenomas.…”
Section: Discussionmentioning
confidence: 99%
“…3). According to this 'just-right signalling' model, the signalling function of APC must be impaired to a specific degree to allow sufficient accumulation of www.nature.com/reviews/cancer R E V I E W S level of expression with maturation, whereas it is virtually absent in the crypt region where cells are actively dividing 104,105 . This pattern of expression is in agreement with the role of β-catenin signalling in maintaining stem-cell properties and controlling differentiation in the intestine 106 .…”
Section: Downstream Targets Of Apc/β-catenin Signallingmentioning
confidence: 99%
“…In support of this, APC mutations have been observed in tumors of the esophagus, stomach, and pancreas (1). In support of this, APC mutations have been observed in tumors of the esophagus, stomach, and pancreas (1).…”
mentioning
confidence: 54%
“…Most APC mutations result in a truncated protein with a detectable loss in the C-terminal region (1,2). Recently, novel antibodies to this C-terminal region have been described that can be used on formalin-fixed, paraffinembedded tissue (1).…”
mentioning
confidence: 99%
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