Apatite-forming ability and mechanical properties of PTMO-modified CaO–SiO2 hybrids prepared by sol–gel processing: effect of CaO and PTMO contents

Miyata, Noboru; Fuke, Ken Ichi; Chen, Qi; Kawashita, Masakazu; Nakamura, Takashi

doi:10.1016/s0142-9612(02)00065-0

Cited by 68 publications

(42 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Miyata et al 27 had earlier synthesized hybrids only using starting compositions of Si-PTMOTEOS weight ratios ranging from 4060 to 5050. In this study, we went further, and examined the apatite-forming ability of PTMO-CaO-SiO 2 hybrids with a wide range of compositions, and used CaCl 2 instead of Ca NO 3 2 .…”

Section: Discussionmentioning

confidence: 99%

“…This compositional region included the compositional range of Si-PTMOTEOS weight ratios ranging from 4060 to 50 50, which was examined by Miyata et al 27 . The apatite-forming ability of the hybrids increased with decreasing Si-PTMO content.…”

Section: Discussionmentioning

confidence: 99%

“…Chen et al 22 -26 successfully synthesized hybrids, which have both flexibility and apatite-forming ability in SBF from the PDMSCaO-SiO 2 -TiO 2 system. Miyata et al 27 used triethoxysilane-functionalized poly tetramethylene oxide Si-PTMO instead of PDMS in efforts to modify the CaO-SiO 2 system to obtain bioactive hybrids with a high capability for deformation. The PTMOCaO-SiO 2 hybrids that they obtained showed apatite-forming ability in SBF and high deformability.…”

Section: Yu and Mackenziementioning

confidence: 99%

See 2 more Smart Citations

Synthesis of Organic-Inorganic Hybrids of Poly(Tetramethylene Oxide)-Calcium Silicate and in vitro Evaluation of Their Bioactivity

Koh

Kawachi

Kikuta

et al. 2007

J. Ceram. Soc. Japan

View full text Add to dashboard Cite

Bioactive organic-inorganic hybrids can be used as biomaterials for bone substitution because they exhibit osteoconduction and other functions due to their organic components, such as flexibility and bioabsorbability. In this study, we synthesized uniform organic-inorganic hybrids from triethoxysilane-functionalized poly tetramethylene oxide Si-PTMO , tetraethoxysilane TEOS and calcium chloride CaCl 2 via the sol-gel process. The starting composition of Si-PTMOTEOS molar had a weight ratio ranging from 2080 to 9010. The CaCl 2 concentration was kept constant at a CaCl 2 TEOS molar ratio of 0.15. Uniform and transparent hybrids were obtained with a Si-PTMOTEOS compositional range from 2080 to 9010. The potential bioactivity was evaluated by determining the formation of a bone-like apatite layer in simulated body fluid SBF . Formation of a bone-like apatite layer was observed on the surface of the organic-inorganic hybrids when they were prepared from starting compositions of Si-PTMOTEOS with weight ratios ranging from 2080 to 5050. An appreciable quantity of the calcium silicate is required to produce bioactive organic-inorganic hybrids.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Yu and Mackenziementioning

confidence: 99%

See 1 more Smart Citation

Synthesis of Organic-Inorganic Hybrids of Poly(Tetramethylene Oxide)-Calcium Silicate and in vitro Evaluation of Their Bioactivity

Koh

Kawachi

Kikuta

et al. 2007

J. Ceram. Soc. Japan

View full text Add to dashboard Cite

show abstract

“…Also, the use of other organic compounds such as polytetramethylene oxide (PTMO), polyethylene oxide (PEO) and poly(ε-caprolactone) [10][11][12] combined with tetraisopropyltitanate (TiTP) as the inorganic component have been tested [13][14][15][16]. Apparently the incorporation of calcium ions is necessary to obtain an apatite-forming ability on the surfaces and hence bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Modulación del carácter hidrofílico e influencia sobre la biocompatibilidad de híbridos base poliuretano-siloxano

Jiménez-Gallegos¹,

Téllez-Jurado²,

Rodríguez‐Lorenzo³

et al. 2011

Bol. Soc. Esp. Ceram. Vidr.

View full text Add to dashboard Cite

Organic-inorganic hybrid materials are known for their outstanding chemical and physical properties. Although some studies have been published regarding the use of hybrids for biomedical applications, relationship between hydrophilic character and biodegradation, bioactivity and biocompatibility has not been studied yet. The sol-gel method has been chosen for the manufacturing of siloxane-polyurethane hybrids for the exceptional potential of the method to obtain nanostructured materials. The effect of the amount of the urethane oligomer (OPU) on the structure, hydrophilic character, degradability, bioactivity and citotoxicity was investigated. Gelling time of these hybrids increases linearly with the decrease on the Siloxane/OPU ratio up to an 80/20 value. Hydrophilic character of the hybrids can be modulated and affects dramatically the degradation rate of the specimens. A hybrid with a 50/50 Siloxane/OPU ratio displayed an appropriate degradation rate, bioactivity and lack of cell toxicity that makes this material a candidate for further studies for applications in bone regeneration.Keywords: Sol-gel process; Biomedical applications; Hybrid Materials; Bioactivity; Polyurethane. Modulación del carácter hidrofílico e influencia sobre la biocompatibilidad de híbridos base poliuretano-siloxanoLos materiales híbridos Orgánico-Inorgánico son conocidos por sus excepcionales propiedades químicas y físicas. Aunque se han publicado algunos estudios respecto al uso de híbridos para aplicaciones biomédicas, aun faltan estudios que determinen la relación que existe entre el carácter hidrofílico de estos materiales y las propiedades que les permiten ser utilizados como biomateriales: degradación, bioactividad y biocompatibilidad. El método sol-gel se ha escogido para la fabricación de híbridos debido a la posibilidad de obtener materiales nanoestructurados que comprenden un componente orgánico y un inorgánico. Se investigó el efecto de la cantidad del olígomero de uretano (OPU) sobre la estructura, el carácter hidrofílico, la degradabilidad, la bioactividad y la citotoxicidad. El tiempo de gelificación de estos híbridos incrementa linealmente con la disminución en la relación Siloxano/OPU hasta un valor de 80/20. El carácter hidrofílico de los híbridos se puede modular y afectar considerablemente la velocidad de degradación de las muestras. Un híbrido con una relación 50/50 Siloxane/OPU muestra una velocidad de degradación, una bioactividad y falta de toxicidad que hacen a este material un candidato para futuros estudios para aplicaciones en regeneración ósea.

show abstract

“…Polydimethylsiloxane (PDMS), 10,11) gelatin, 12) poly(tetramethylene oxide) (PTMO), 13) polymethylmethacrylate (PMMA), 14,15) poly(hydroxyethyl methacrylate), 16) alginate, 17) polycaprolactone 18) and so on have been reported as organic polymers for a component of bioactive hybrids. We have paid attention on starch as an organic polymer.…”

Section: Introductionmentioning

confidence: 99%

Effects of Cross-Linking Agent on Apatite-Forming Ability and Mechanical Property of Organic-Inorganic Hybrids Based on Starch

et al. 2007

View full text Add to dashboard Cite

So-called bioactive ceramics can directly bond to living bone through the apatite layer formed on their surfaces in the body. However, hard and brittle character of ceramics limits their clinical applications to low loaded portions. The apatite deposition on the bioactive ceramics is known to be triggered by a catalytic effect of silanol (Si-OH) groups formed on their surfaces and by release of calcium ions (Ca 2þ ) that increases degree of supersaturation of the surrounding fluid with respect to the apatite. It is expected that organic modification of these components would produce bioactive materials with mechanical properties analogous to natural bone. We previously reported that bioactive organic-inorganic hybrids can be prepared from starch by modification with glycidoxypropyltrimethoxysilane (GPS) that provides with Si-OH groups and calcium chloride that releases calcium ions. In this study, we examined effect of synthetic conditions of the hybrids on their bioactivity and mechanical properties. We prepared several hybrids with different content of divinylsulfone as a cross-linking agent. Their bioactivity was examined in simulated body fluid (SBF, Kokubo solution) with inorganic ion concentrations nearly equal to those of human extracellular fluid. Materials that form the apatite on their surfaces in SBF are known to have a potential to show the bone-bonding. It was found that the added cross-linking agent did not decrease apatite-forming ability of the hybrids in SBF. Mechanical properties of the hybrids were further evaluated by a tensile test. Tensile strength and Young's modulus increased with increasing content of divinylsulfone.

show abstract

Apatite-forming ability and mechanical properties of PTMO-modified CaO–SiO2 hybrids prepared by sol–gel processing: effect of CaO and PTMO contents

Cited by 68 publications

References 19 publications

Synthesis of Organic-Inorganic Hybrids of Poly(Tetramethylene Oxide)-Calcium Silicate and in vitro Evaluation of Their Bioactivity

Synthesis of Organic-Inorganic Hybrids of Poly(Tetramethylene Oxide)-Calcium Silicate and in vitro Evaluation of Their Bioactivity

Modulación del carácter hidrofílico e influencia sobre la biocompatibilidad de híbridos base poliuretano-siloxano

Effects of Cross-Linking Agent on Apatite-Forming Ability and Mechanical Property of Organic-Inorganic Hybrids Based on Starch

Contact Info

Product

Resources

About