Synthesis of Organic-Inorganic Hybrids of Poly(Tetramethylene Oxide)-Calcium Silicate and in vitro Evaluation of Their Bioactivity

Abstract

Bioactive organic-inorganic hybrids can be used as biomaterials for bone substitution because they exhibit osteoconduction and other functions due to their organic components, such as flexibility and bioabsorbability. In this study, we synthesized uniform organic-inorganic hybrids from triethoxysilane-functionalized poly tetramethylene oxide Si-PTMO , tetraethoxysilane TEOS and calcium chloride CaCl 2 via the sol-gel process. The starting composition of Si-PTMOTEOS molar had a weight ratio ranging from 2080 to 9010. The CaCl 2 concentration was kept constant at a CaCl 2 TEOS molar ratio of 0.15. Uniform and transparent hybrids were obtained with a Si-PTMOTEOS compositional range from 2080 to 9010. The potential bioactivity was evaluated by determining the formation of a bone-like apatite layer in simulated body fluid SBF . Formation of a bone-like apatite layer was observed on the surface of the organic-inorganic hybrids when they were prepared from starting compositions of Si-PTMOTEOS with weight ratios ranging from 2080 to 5050. An appreciable quantity of the calcium silicate is required to produce bioactive organic-inorganic hybrids.

The effect of silicon doping on the transformation of amorphous calcium phosphate to silicon-substituted α-tricalcium phosphate by heat treatment

“…4(b′)). The band at 870 cm À 1 was attributed to Si-O stretching bands in silicates [30], while the bands at 800 and 685 cm À 1 were associated with Si-O bands in amorphous silica [31,32]. More importantly, the FT-IR absorption bands of PO 4 3− differed considerably among the sintered samples.…”