Apatite Formation Induced by Chitosan/Gelatin Hydrogel Coating Anchored on Poly(aryl ether nitrile ketone) Substrates to Promote Osteoblastic Differentiation

Li, Yizheng; Liu, Chengde; Li, Wentao; Cheng, Xitong; Zhang, Ali; Zhang, Shouhai; Liu, Cheng; Li, Nan; Jian, Xigao

doi:10.1002/mabi.202100262

Cited by 14 publications

(7 citation statements)

References 50 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Firstly, it can induce calcium deposition on the surface of the coating, thus improving the mineralization ability and promoting osteogenesis. Li et al (2021 ) coated the CS/gelatin hydrogel on the poly (aryl ether nitrile ketone)-containing phthalazinone moiety substrate (PPENK) through the spin coating method. Due to the presence of CS, this composite coating can chelate Ca 2+ to promote the deposition of calcium phosphate at the mineral phase on the surface of the PPENK matrix and enhance the biomineralization potential of the coating, which has exhibited biocompatibility and osteogenic properties for MCET3-E1.…”

Section: Application In the Treatment Of Infected Bone Defectsmentioning

confidence: 99%

Chitosan-Based Biomaterial Scaffolds for the Repair of Infected Bone Defects

Tian

Wu²,

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The treatment of infected bone defects includes infection control and repair of the bone defect. The development of biomaterials with anti-infection and osteogenic ability provides a promising strategy for the repair of infected bone defects. Owing to its antibacterial properties, chitosan (an emerging natural polymer) has been widely studied in bone tissue engineering. Moreover, it has been shown that chitosan promotes the adhesion and proliferation of osteoblast-related cells, and can serve as an ideal carrier for bone-promoting substances. In this review, the specific molecular mechanisms underlying the antibacterial effects of chitosan and its ability to promote bone repair are discussed. Furthermore, the properties of several kinds of functionalized chitosan are analyzed and compared with those of pure chitosan. The latest research on the combination of chitosan with different types of functionalized materials and biomolecules for the treatment of infected bone defects is also summarized. Finally, the current shortcomings of chitosan-based biomaterials for the treatment of infected bone defects and future research directions are discussed. This review provides a theoretical basis and advanced design strategies for the use of chitosan-based biomaterials in the treatment of infected bone defects.

show abstract

Section: Application In the Treatment Of Infected Bone Defectsmentioning

confidence: 99%

Chitosan-Based Biomaterial Scaffolds for the Repair of Infected Bone Defects

Tian

Wu²,

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Poly(aryl ether ketone) (PAEK) exhibits the excellent mechanical performances and thermal stability; therefore, using the engineering thermoplastic PAEK as the SMP matrix polymer is expected to satisfy the requirements of mechanical properties and could extend the utilization potential of SMPs in engineering structures. − At present, there are several papers investigating the modified shape memory PAEK materials, which mainly focus on the thermoplastic structures and properties. − In this paper, metal coordination bonds between pyridine and metal ions were integrated into the PAEK matrix to construct metal-coordinated shape memory PAEK materials. The tuning of the content and species of metal ions was operated to improve the shape memory ability.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Shape Memory Metal-Coordinated Poly(aryl ether ketone)s with Tunable Gradient-Deformation Behaviors as well as Self-Healing and Reprocessing Abilities

Yang

Leng

2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Reversible dynamic bonds are able to crack and recombine upon external stimuli, which endow polymers with exceptional self-healing, reprocessing, and reversible deformation ability. In this paper, we integrated the metal coordination bonds into shape memory poly(aryl ether ketone) (PAEK) to fabricate smart materials with multifunctionalities. Through tuning the metal ion content and species, the enhancement of shape memory behaviors was achieved, including the high recovery ratio (over 98%) and fixity ratio (over 98%), which was closely related to the synergic effect of the intrinsic motion ability of PAEK matrix and the cracking-recombination of coordination bonds. Besides, through the combination of the components with different Cu 2+ contents, in addition to the components with Fe 2+ coordination bonds, we fabricated the gradient shape memory structures with controllable shape memory and recovery behaviors. The manipulation of gradient coordination bonds resulted in different shape recovery speeds and directions. Furthermore, due to the dynamic cracking-recombination of coordination bonds, the metal-coordinated PAEK material exhibited the great selfhealing and reprocessing performances, which were significant for largely extending its application range.

show abstract

“…As shown in Figure a,b, the cell viability on the surface of all samples reached more than 90%, indicating that the coated PPENK was not cytotoxic. The proliferation assay (Figure c) demonstrated that the cell proliferation on the surface of the samples increased exponentially with time and was not significantly different from the remaining samples, proving that the samples did not promote cell proliferation …”

Section: Resultsmentioning

confidence: 99%

“…The proliferation assay (Figure 5c) demonstrated that the cell proliferation on the surface of the samples increased exponentially with time and was not significantly different from the remaining samples, proving that the samples did not promote cell proliferation. 53 The effect of the apatite coating on the properties of the PPENK surface was then investigated by cell adhesion and viability assays. 54 After 1, 2, and 3 days of cultivation of cells onto the sample surface, a live/dead staining of the cells on sample surface was performed.…”

Section: Effect Of 3d Nanoporousmentioning

confidence: 99%

Stabilization of Apatite Coatings on PPENK Surfaces by Mechanical Interlocking to Promote Bioactivity and Osseointegration In Vivo

Cheng

Yang

Liu

et al. 2022

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Apatite coatings with high stability can effectively improve the surface bioactivity and osteogenic activity of implant materials. In clinical practice, the ability of apatite coatings to bond with the substrate is critical to the effect of implants. Here, we propose a strategy to construct a three-dimensional (3D) nanoporous structure on the surface of a poly(phthalazinone ether nitrile ketone) (PPENK) substrate and introduce a polydopamine (PDA) coating with grafted phosphonate groups to enhance the overall deposition of a bone-like apatite coating in the 3D nanoporous structure during mineralization. This method leads to a mechanical interlocking between the apatite coating and the substrate, which increases the stability of the apatite coating. The apatite coating confers a better bioactive surface to PPENK and also promotes osteogenic differentiation and adhesion of MC3T3-E1 osteoblasts in vitro. The samples are then implanted into rat femurs to characterize in vivo osseointegration. Micro-CT data and histological staining of tissue sections reveal that PPENK with a stable apatite coating induces less fibrous capsule formation and no inflammatory response and promotes osteogenic differentiation and bone-bonding strength. This enhances the long-term use of PPENK implant materials and shows great potential for clinical application as orthopedic implants.

show abstract

Apatite Formation Induced by Chitosan/Gelatin Hydrogel Coating Anchored on Poly(aryl ether nitrile ketone) Substrates to Promote Osteoblastic Differentiation

Cited by 14 publications

References 50 publications

Chitosan-Based Biomaterial Scaffolds for the Repair of Infected Bone Defects

Chitosan-Based Biomaterial Scaffolds for the Repair of Infected Bone Defects

Enhanced Shape Memory Metal-Coordinated Poly(aryl ether ketone)s with Tunable Gradient-Deformation Behaviors as well as Self-Healing and Reprocessing Abilities

Stabilization of Apatite Coatings on PPENK Surfaces by Mechanical Interlocking to Promote Bioactivity and Osseointegration In Vivo

Contact Info

Product

Resources

About