Apathy and Reduced Speed of Processing Underlie Decline in Verbal Fluency following DBS

Foley, Jennifer A.; Foltynie, Tom; Zrinzo, Ludvic; Hyam, Jonathan A.; Limousin, Patricia; Cipolotti, Lisa

doi:10.1155/2017/7348101

Cited by 19 publications

(13 citation statements)

References 86 publications

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“…Nonetheless, after DBS, both sexes show a similar functional improvement (Hariz et al, 2013). Although it is effective at motor symptom alleviation, DBS can also induce adverse side effects such as an aggravation of freezing of gait and worsening of verbal fluency (Carlson et al, 2014;Foley et al, 2017;Højlund et al, 2017). Yet another downside of DBS is that PD-induced speech disruption is much less responsive to DBS than any other motor dysfunctions (Limousin and Martinez-Torres, 2008;Moro et al, 2010).…”

Section: Deep Brain Stimulationmentioning

confidence: 99%

Strategies for the Treatment of Parkinson’s Disease: Beyond Dopamine

Iarkov

Barreto

Grizzell

et al. 2020

Front. Aging Neurosci.

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Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of intraneuronal α-synuclein-positive inclusions. Therapies to date have been directed to the restoration of the dopaminergic system, and the prevention of dopaminergic neuronal cell death in the midbrain. This review discusses the physiological mechanisms involved in PD as well as new and prospective therapies for the disease. The current data suggest that prevention or early treatment of PD may be the most effective therapeutic strategy. New advances in the understanding of the underlying mechanisms of PD predict the development of more personalized and integral therapies in the years to come. Thus, the development of more reliable biomarkers at asymptomatic stages of the disease, and the use of genetic profiling of patients will surely permit a more effective treatment of PD.

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Section: Deep Brain Stimulationmentioning

confidence: 99%

Strategies for the Treatment of Parkinson’s Disease: Beyond Dopamine

Iarkov

Barreto

Grizzell

et al. 2020

Front. Aging Neurosci.

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“…Of the 13 studies, only 1 had a healthy control group, 15 4 compared only PD versus DBS PD patients, 12,13,16,18 7 were tested before and after DBS implantation or ON/ OFF condition, [8][9][10][11]14,16,17,19 and 1 compared DBS patients versus GPi patients. 7 The review found limited use of control groups for comparing results in most studies and the absence of a specific assessment protocol for PD with and without STN-DBS (evidenced by the variability of instruments used in the different studies, 40 overall).…”

Section: Resultsmentioning

confidence: 99%

“…In summary: [1] Verbal Fluency -Decrease in verbal fluency test scores 8,10,17,19 no reduction in verbal fluency after STN stimulation. 11,14 [2] Memory -One of the studies showed no changes after STN DBS in memory or verbal learning, both of which remained stable after implantation.…”

Section: Authors and Yearmentioning

confidence: 99%

“…14,17 [3] Processing speed -Significantly reduced after DBS, representing the most important predictor of decline in verbal fluency tests. 19 [4] Inhibitory control -Stroop test worsened after stimulation and Random Number Generation Task (RNGT) counting after stimulation worsened in one study. 8 These effects may be induced by stimulation of the associative territory of the STN, but there was no significant difference between groups with and without DBS.…”

Section: Authors and Yearmentioning

confidence: 99%

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Executive Functions in Parkinson’s disease with and without Deep Brain Stimulation (DBS): A systematic review

Arten

Hamdan

2020

Dement. neuropsychol.

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ABSTRACT. Given the aging of the world population, it is essential to investigate which methods are most effective for treating the diseases that manifest with age. This study addresses Parkinson’s disease (PD), for which Deep Brain Stimulation (DBS) has been increasingly used to treat the disease. Objective: To investigate Executive Functions (EF) in patients with and without DBS. Methods: A systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyzes (PRISMA) criteria. Scientific papers published on the Scopus, Web of Science and PsycInfo databases were selected. Results: 13 articles were selected. Results showed no standardization of instruments used to evaluate EF and that, in most studies, lack of a control group may have affected results. Conclusion: Decline in EF was observed in terms of verbal fluency and processing speed in patients with DBS.

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“…Our results further expand these findings by establishing that the number of words generated across the six 10-second periods of each VF task was not affected by acute STN stimulation, thus showing that STN-DBS does not alter the speed or rate of word generation during VF. Some previous studies examining the surgical effect of STN-DBS on VF have suggested that the postsurgical decline in VF results from “an intact lexicon running slowly” [18] or a slower speed of processing [19]. However, in both these studies, this conclusion was based on correlations between VF tests and independent measures of speed of processing such as a lexical decision task or symbol search and digit symbol coding rather than direct measurement of the number of words generated across time in each VF task as in the present study.…”

Section: Discussionmentioning

confidence: 99%

Subthalamic Nucleus Stimulation Does Not Have Any Acute Effects on Verbal Fluency or on Speed of Word Generation in Parkinson’s Disease

Atkinson-Clément¹,

Leimbach

Jahanshahi

2019

Parkinson's Disease

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Background Deep brain stimulation of the subthalamic nucleus (STN-DBS) has been shown to be generally safe from a cognitive perspective, with consistent evidence that the major impact of STN-DBS in Parkinson's disease (PD) is on verbal fluency. Objective The aim of this study was first to identify the influence of acute manipulation of STN-DBS in PD on the number and time pattern of word generation on different verbal fluency (VF) tasks, phonemic, switching, and cued switching, and second to determine whether cueing improved VF and if cueing effects interacted with STN-DBS effects. Methods Parallel versions of these three verbal fluency tasks were completed by 31 patients with Parkinson's disease who had had bilateral DBS of the STN, twice, with DBS On and Off, with the order counterbalanced across patients. Results There was no effect of acute STN-DBS on the total number of words generated during verbal fluency. As expected, the number of words generated significantly declined over the six 10-second intervals of the verbal fluency tasks, but this time pattern of word generation was not altered by STN-DBS. External cueing significantly increased the number of words generated relative to an uncued switching verbal fluency task, but the cueing effect on VF was not altered by STN-DBS. Conclusion In conclusion, (i) acute STN-DBS manipulation did not alter either verbal fluency performance or the time pattern of word generation and (ii) external cueing significantly improved verbal fluency performance both with STN-DBS On and Off.

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Apathy and Reduced Speed of Processing Underlie Decline in Verbal Fluency following DBS

Cited by 19 publications

References 86 publications

Strategies for the Treatment of Parkinson’s Disease: Beyond Dopamine

Strategies for the Treatment of Parkinson’s Disease: Beyond Dopamine

Executive Functions in Parkinson’s disease with and without Deep Brain Stimulation (DBS): A systematic review

Subthalamic Nucleus Stimulation Does Not Have Any Acute Effects on Verbal Fluency or on Speed of Word Generation in Parkinson’s Disease

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