Apathy and cognitive performance in older adults with depression

Feil, Denise; Razani, Jill; Boone, Kyle Brauer; Lesser, Ira M.

doi:10.1002/gps.869

Cited by 89 publications

(58 citation statements)

References 42 publications

(42 reference statements)

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“…Post-stroke apathy is a disabling symptom present in 20-55% of stroke survivors [6,7,9,10,11,12,13,14,15]. Post-stroke apathy has been associated with post-stroke cognitive impairment [6,10,12,15,16], and specifically with executive functioning impairment [6,17,18,19,20], but not all studies supported that association [7,11,13,14,21,22,23]. …”

Section: Introductionmentioning

confidence: 99%

Post-Stroke Apathy: An Exploratory Longitudinal Study

Caeiro

Ferro²,

Melo³

et al. 2013

Cerebrovasc Dis

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Introduction: Post-stroke apathy is a disturbance of motivation evidenced by low initiative, difficulties in starting, sustaining or finishing any goal-directed activity, low self-activation or self-initiated behavior and emotional indifference. Apathy is a common behavioral disturbance in stroke survivors. We aimed to analyze the relationship between post-stroke apathy at 1 year after stroke and (1) apathy in acute phase; (2) demographic, pre-stroke predisposing conditions (previous mild cognitive impairment, alcohol abuse, mood/anxiety disorder) and clinical features (stroke type and location, neurological symptoms); (3) post-stroke depression and post-stroke cognitive impairment, and (4) post-stroke functional outcome, quality of life and the perception of health. Methods: Consecutive stroke (infarct/intracerebral hemorrhage) patients without aphasia or consciousness disturbances were included in the acute phase of stroke and assessed at 1 year after stroke. We assessed apathy with the clinically rated version of the Apathy Evaluation Scale. We also assessed post-stroke depression (Montgomery Asberg Depression Rating Scale) and post-stroke cognitive impairment (attention, mental flexibility, verbal, motor and graphomotor initiative, and non-verbal and verbal abstract reasoning, and Mini-Mental State Examination), functional outcome (Barthel Index), quality of life and perception of health (EuroQol). Data were analyzed using bivariate associations (χ² and t test) and stepwise multivariate analysis. Results: We included 76 stroke patients [32.9% women, mean age 62.9 years (SD = 10.9) and a mean of 6.9 (SD = 4.3) years of education]. Apathy was present in 17 patients in the acute phase and in 18 (23.7%) patients at 1 year after stroke. At 1 year after stroke, 41% of the acute apathetic patients remained apathetic. Sixty-one percent of new cases of post-stroke apathy were detected. Post-stroke apathy was associated only with previous cognitive impairment, apathy in acute stroke, post-stroke cognitive impairment, verbal abstract reasoning and with worse Barthel Index scale scores. In the multivariate logistic regression model, verbal abstract reasoning (odds ratio, OR = 7.03) and apathy in acute stroke (OR = 3.8) were identified as independent factors for post-stroke apathy at 1 year. Apathetic patients did not report worse quality of life or health. Conclusion: Apathy in acute stroke phase was a reliable indicator of post-stroke apathy. Apathy should be assessed in both phases. Verbal abstract reasoning impairment was also an independent factor for post-stroke apathy impairing patients' ability to reason about goal-directed activity. Even though apathetic patients had worse post-stroke functional outcome, they did not report losing quality of life or having worse health.

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Section: Introductionmentioning

confidence: 99%

Post-Stroke Apathy: An Exploratory Longitudinal Study

Caeiro

Ferro²,

Melo³

et al. 2013

Cerebrovasc Dis

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“…The diagnosis and treatment of speech and language pathologies in dementia is problematic because there are no standard methods. We hypothesized that presence of apathy in depression is associated with poorer frontal executive performance similar to Feil et al (9).…”

Section: Discussionmentioning

confidence: 75%

Memantin Responsive Behcet?s Disease With Initial Onset Severe Cognitive Decline

Koçer

Canan

et al. 2007

ELECTRON J GEN MED

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Turkey Behcet's Disease (BD) is chronic, multisystem inflammatory disorder with vasculitis as the underlying process and most commonly affects the brain stem with a patchy involvement of upper parts in the nervous system. Although predominant mental symptoms are the main forms of nervous system involvement, mental changes and psychiatric problems are seen at later stages of BD. We report a case with Behcet's disease initially presented with depression and dementia. The most prominent findings were depression and cognitive impairement with gait ataxia. This case was treated with steroids, serotonin selective reuptake inhibitors and memantin. The initial presentation of memory problems and depression in neurological involvements of BD have not yet been reported in literature. Therefore, our case who had an onset with psychiatric complaints and memory problems is an interesting one.

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“…Estudos sugerem a presença de déficits neuropsicológicos em Episódio de Depressivo Maior (Feil, Razani, & Boone, 2003;Laks, Marinho, Rosenthal, & Engelhardt, 1999). Esses déficits cognitivos mais comumente afetados são: evocação após intervalo de tempo, aquisição da memória, atenção, concentração, flexibilidade cognitiva e abstração (Zakzanis, Leach, & Kaplan, 1999 Cunha (2000;2001) e subdividem-se de 0 a 10 = mínimo; de 11 a 19 = leve; de 20 a 30 = moderado; e de 31 a 63 = grave.…”

Section: Introductionunclassified

Correlaciones entre ansiedad y depresión en el rendimiento cognitivo de las personas mayores

Lopes

Wendt

Nascimento

et al. 2014

Divers.: Perspect. Psicol.

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ResumoObserva-se que com o passar dos anos, o organismo humano passa por um processo natural de envelhecimento, gerando modificações funcionais, diminuindo a vitalidade e favorecendo o aparecimento de doenças relacionadas a esse período de vida. Os principais fatores de risco para o desenvolvimento da depressão no idoso compreendem aspectos genéticos, eventos estressantes, deterioro cognitivo associado à idade e alterações neurobiológicas, sendo que as taxas de prevalência de transtorno depressivo maior em idosos variam entre 2 % a 5 %. Idosos com sintomas depressivos e sintomas de ansiedade mais graves apresentaram déficits cognitivos. O objetivo desse estudo é verificar se há existe correlação entre significativa entre o desempenho cognitivo de idosos com sintomas de depressão, ansiedade e idade. Participaram desse estudo 231 idosos. O delineamento foi de um estudo quantitativo e transversal. Utilizou-se o Mini-Exame do Estado Mental (MEEM), a

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Apathy and cognitive performance in older adults with depression

Abstract: The results of this study provide support for an apathy syndrome associated with poorer executive function in older adults with major depression.

Cited by 89 publications

References 42 publications

Post-Stroke Apathy: An Exploratory Longitudinal Study

Post-Stroke Apathy: An Exploratory Longitudinal Study

Memantin Responsive Behcet?s Disease With Initial Onset Severe Cognitive Decline

Correlaciones entre ansiedad y depresión en el rendimiento cognitivo de las personas mayores

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