Aortitis and aortic aneurysm in systemic vasculitis

García‐Martínez, Ana; Prieto-González, Sergio; Giménez, Pedro Arguis; Espígol‐Frigolé, Georgina; Hernández‐Rodríguez, José; Cid, María C.

doi:10.5772/18875

Cited by 4 publications

(3 citation statements)

References 61 publications

(73 reference statements)

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“…Aortic involvement by GCA has been sporadically reported in small necropsy studies or surgical series for decades3–5 but the prevalence of aortic inflammation in GCA has remained undefined until recently when the development of imaging techniques has allowed detection of aortitis at early disease stages, before the development of aortic complications requiring surgery or death 6–8. Using positron emission tomography or CT angiography, up to 45–65% of GCA patients can be identified exhibiting radiological signs of aortic inflammation at the time of diagnosis 6–8.…”

Section: Introductionmentioning

confidence: 99%

Prospective long term follow-up of a cohort of patients with giant cell arteritis screened for aortic structural damage (aneurysm or dilatation)

et al. 2013

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Section: Introductionmentioning

confidence: 99%

Prospective long term follow-up of a cohort of patients with giant cell arteritis screened for aortic structural damage (aneurysm or dilatation)

et al. 2013

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“…Unlike other types of aortitis, IDA has an indolent course. Retrospective studies show that approximately greater than half of patients with IDA have no prior history or symptoms of vasculitis (3), and most cases of IDA are diagnosed incidentally on histological examination after surgical removal (4,5).…”

Section: Discussionmentioning

confidence: 99%

Isolated idiopathic aortitis with an unusually thickened aortic wall: case report

et al. 2016

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Aortitis includes a broad range of disorders involving inflammation of the aorta. While most forms of aortitis can be linked to a specific cause, patients with idiopathic aortitis (IDA), are asymptomatic and usually diagnosed after surgical removal. The specific pathophysiology is not well understood, but can be strongly associated with tobacco smoking, young age at presentation, and family history of aortic aneurysm. Wall thickening is the most common physical characteristic of aortitis, and the inflammation can affect any layer of the aorta.The normal wall thickness of the aorta is less than 4 mm and can be as thick as 9 mm. Few studies document a correlation between wall thickness and the severity of aortitis. This paper presents a unique case of severe aortic aneurysm associated with an abnormal thickening of the ascending aorta.

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“…С учетом отсут-ствия предшествующего иммуносупрессивного лечения у нашей пациентки планируется назначение предни-золона в дозе 50 мг/сут под контролем клинико-лабо-раторных данных, ПЭТ-КТ. заключение Таким образом, «стертость» клинической картины ранних форм АТ, отсутствие специфических воспали-тельных маркеров в крови, неопределенность вопросов этиологии и патогенеза могут приводить к ошибкам в диагностике данного заболевания [29]. Представлен-ное клиническое наблюдение показывает, насколько важно всесторонне обследовать пациента молодого возраста с жалобой на повышение АД в течение мно-гих лет.…”

Section: клиническое наблюдениеunclassified

Systemic Vasculitis With Lesion of Large Vessels as a Cause of Art Erial Hypert Ension in a Patient of Young Age

et al. 2018

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Objective:to analyze and present a clinical case of late diagnosis of Takayasu’s arteritis in a young female patient with long-term arterial hypertension.Materials and methods.The female patient G., born in 1989, had noted elevated arterial pressure (AP) of 150/90 mm Hg since she was 14. At 21 the following diagnosis was stated: Fibro-muscular dysplasia, stenosis of the left renal artery. Stenosis of the celiac trunk. Aneurisms of the branches of the superior mesenteric artery; prosthesis of the left renal artery was performed. Since the beginning of 2016, the patient has noted elevated AP of 200/110 mm Hg despite continuing hypotensive therapy. Diagnosis of Nonspecific aortoarteritis was proposed in May of 2017. Methylprednisolone therapy was administered: 250 mg No. 2 intravenously, Prednisolone: 25 mg a day orally. Due to signs of decreased blood flow to the left kidney, in August of 2017 extracorporeal repeat prosthesis of the left renal artery, bypass of the right middle renal artery with reversed autovein were performed.Results.During examination in October of 2017, the patient complained of weakness, frequent elevated AP of 200/110 mm Hg. In blood test: hemoglobin 106 g/l, erythrocyte sedimentation rate 38 mm/h, C-reactive protein 25 mg/l. A heterozygous mutation in the methylenetetrahydropholate reductase, a heterozygous mutation in the factor V gene (G1691A) were identified. Homocysteine level was normal, infection and oncological pathology were excluded. The following diagnosis was made: Takayasu»s arteritis type IV affecting the aorta and its branches, moderate activity. Occlusion of the celiac trunk. Aneurisms of the branches of the superior mesenteric artery. Critical stenosis of the left renal artery. Thrombosis of the aorto-renal prosthesis. Hypoplasia of the left kidney. Prednisolone 50 mg a day, metoprolol 50 mg a day, valsartan 160 mg a day, acetylsalicylic acid 100 mg a day were prescribed.Conclusion.The presented clinical observation shows the importance of comprehensive examination of young patients complaining of elevated AP for many years. Due to untimely diagnosis and absence of pathogenetic therapy, the patient suffered negative consequences of surgical treatment.

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Aortitis and aortic aneurysm in systemic vasculitis

Cited by 4 publications

References 61 publications

Prospective long term follow-up of a cohort of patients with giant cell arteritis screened for aortic structural damage (aneurysm or dilatation)

Prospective long term follow-up of a cohort of patients with giant cell arteritis screened for aortic structural damage (aneurysm or dilatation)

Isolated idiopathic aortitis with an unusually thickened aortic wall: case report

Systemic Vasculitis With Lesion of Large Vessels as a Cause of Art Erial Hypert Ension in a Patient of Young Age

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