Aortic valve disease and treatment: The need for naturally engineered solutions

Butcher, Jonathan T.; Mahler, Gretchen J.; Hockaday, Laura A.

doi:10.1016/j.addr.2011.01.008

Cited by 173 publications

(179 citation statements)

References 421 publications

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“…2,3 Tissue engineering seeks to address this critically unmet need by providing a living valvular replacement that is capable of growth and integration and only one surgery. 4,5 One of the challenges for tissue-engineered heart valve (TEHV) is to find suitable cell sources. Early studies demonstrated that allogenic cell sources caused an acute inflammatory response even in the presence of immunosuppressant treatment.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Mesenchymal Stem Cell Source Differentiation Toward Human Pediatric Aortic Valve Interstitial Cells within 3D Engineered Matrices

Duan

Hockaday

Das

et al. 2015

Tissue Engineering Part C: Methods

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Section: Introductionmentioning

confidence: 99%

Comparison of Mesenchymal Stem Cell Source Differentiation Toward Human Pediatric Aortic Valve Interstitial Cells within 3D Engineered Matrices

Duan

Hockaday

Das

et al. 2015

Tissue Engineering Part C: Methods

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“…7,8 Various approaches to create viable semilunar heart valves with remodelling capabilities have been developed by means of tissue engineering (TE). 9,10 The general approach is to mimic the shape of the native valve to recreate the natural haemodynamics 11 either by replicating the whole valvular apparatus, including the vascular part (wall) [12][13][14][15] or by reproducing only the cusps to be sutured to the native wall. [16][17][18][19] Both approaches have important limitations.…”

mentioning

confidence: 99%

Tissue-Engineered Fibrin-Based Heart Valve with a Tubular Leaflet Design

Weber

Heta

Moreira

et al. 2014

Tissue Engineering Part C: Methods

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The general approach in heart valve tissue engineering is to mimic the shape of the native valve in the attempt to recreate the natural haemodynamics. In this article, we report the fabrication of the first tissue-engineered heart valve (TEHV) based on a tubular leaflet design, where the function of the leaflets of semilunar heart valves is performed by a simple tubular construct sutured along a circumferential line at the root and at three single points at the sinotubular junction. The tubular design is a recent development in pericardial (nonviable) bioprostheses, which has attracted interest because of the simplicity of the construction and the reliability of the implantation technique. Here we push the potential of the concept further from the fabrication and material point of view to realize the tube-in-tube valve: an autologous, living HV with remodelling and growing capability, physiological haemocompatibility, simple to construct and fast to implant. We developed two different fabrication/conditioning procedures and produced fibrin-based constructs embedding cells from the ovine umbilical cord artery according to the two different approaches. Tissue formation was confirmed by histology and immunohistology. The design of the tube-in-tube foresees the possibility of using a textile coscaffold (here demonstrated with a warp-knitted mesh) to achieve enhanced mechanical properties in vision of implantation in the aortic position. The tube-in-tube represents an attractive alternative to the conventional design of TEHVs aiming at reproducing the valvular geometry.

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“…Los velos valvulares son estructuras no vascularizadas, flexibles y muy finas, puesto que tienen un espesor menor de 1mm [57]. Están formadas por tres capas: la ventricular, la esponjosa y la fibrosa.…”

Section: Velos Valvulares Naturalesunclassified

“…Nacen de la zona de la comisura y se extienden hasta el extremo libre del velo [58]. Las presiones que soportan los velos valvulares son del orden de 0.05 MPa en sístole y de 0.5 MPa en diástole [57]. [79] ensayaron pericardio bovino tratado con glutaraldehído al 0.625%.…”

Section: Velos Valvulares Naturalesunclassified

Caracterización mecánica de materiales de base colágeno para aplicaciones cardiovasculares

Arnedo¹,

Almudena²

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Aortic valve disease and treatment: The need for naturally engineered solutions

Cited by 173 publications

References 421 publications

Comparison of Mesenchymal Stem Cell Source Differentiation Toward Human Pediatric Aortic Valve Interstitial Cells within 3D Engineered Matrices

Comparison of Mesenchymal Stem Cell Source Differentiation Toward Human Pediatric Aortic Valve Interstitial Cells within 3D Engineered Matrices

Tissue-Engineered Fibrin-Based Heart Valve with a Tubular Leaflet Design

Caracterización mecánica de materiales de base colágeno para aplicaciones cardiovasculares

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