Aortic Root Dilatation Is Associated With Incident Cardiovascular Events in a Population of Treated Hypertensive Patients: The Campania Salute Network

Canciello, Grazia; Mancusi, Costantino; Losi, Maria Angela; Izzo, Raffaele; Trimarco, Bruno; Simone, Giovanni de; Luca, Nicola De

doi:10.1093/ajh/hpy113

Cited by 29 publications

(42 citation statements)

References 31 publications

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“…Echocardiographic findings in people, dogs, and cats with systemic hypertension (SH) include normal ventricular wall thickness to variable degrees of left ventricular hypertrophy 1–10 . The most recent SH guidelines from the American College of Veterinary Internal Medicine (ACVIM) in 2018 recognized concentric left ventricular hypertrophy, aortic aneurysm, and left‐sided congestive heart failure as evidence of target organ damage in both dogs and cats with SH 1,2 .…”

Section: Introductionmentioning

confidence: 99%

“…The most recent SH guidelines from the American College of Veterinary Internal Medicine (ACVIM) in 2018 recognized concentric left ventricular hypertrophy, aortic aneurysm, and left‐sided congestive heart failure as evidence of target organ damage in both dogs and cats with SH 1,2 . Left ventricular hypertrophy is an inconsistent finding of SH in people 5,6 . Aortic aneurysm formation 11 and left‐sided heart failure 7,12 have been associated with long standing SH in people.…”

Section: Introductionmentioning

confidence: 99%

“…Aortic aneurysm formation 11 and left‐sided heart failure 7,12 have been associated with long standing SH in people. Aortic dilatation has been included as a complication of SH in dogs and cats 2 and, in people, precedes or occurs independently of left ventricular hypertrophy 5,6 . Case reports of both feline and canine patients identified aortic dilation/aneurysm and aortic dissection secondary to SH on echocardiograms 13–16 .…”

Section: Introductionmentioning

confidence: 99%

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Echocardiographic changes in the shape and size of the aortic cusps in dogs with confirmed systemic hypertension

Holland

Hofmeister

Hudson

2021

Vet Radiology Ultrasound

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Systemic hypertension (SH) in dogs typically occurs secondary to renal disease, diabetes mellitus, hyperadrenocorticism, malignant adrenal tumors, or various medications. Echocardiography performed on people with SH has shown asymmetric dilation of the sinuses at the level of the aortic valves, previously undescribed in canine patients. The objective of this retrospective case‐control study was to determine if there was a difference in size and shape of the aortic cusps at the level of the sinus of Valsalva in dogs with SH compared to dogs with normal blood pressure. We reviewed echocardiographic findings in 74 dogs with SH and 37 dogs with normal blood pressure (NBP), defined as less than 150 mmHg. Systemic hypertension was classified as mild (150‐159 mm Hg), moderate (160‐179 mm Hg), or severe (greater than 180 mm Hg). There was a significant difference (P < .001) in the mean size of the aorta cusps at the level of the sinuses in 67 of 74 dogs with SH and none of 37 dogs with NBP. Of the 74 dogs with SH, 70 had left ventricular hypertrophy (18 asymmetric, 15 concentric, and 37 eccentric). Additionally, there was aortic root dilatation in 15 dogs, aortic insufficiency in 21, mitral regurgitation in 50, and left atrial enlargement in 71. The standard deviation of the three cusp measurements between the dogs with SH and dogs with NBP had a sensitivity of 92% and specificity of 97% for diagnosis of SH. Asymmetric size of the aortic cusps on echocardiography is therefore a reliable indicator of SH in dogs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Echocardiographic changes in the shape and size of the aortic cusps in dogs with confirmed systemic hypertension

Holland

Hofmeister

Hudson

2021

Vet Radiology Ultrasound

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“…4 Canciello et al published previous findings on the predictive value of ARD in treated hypertensive patients on incident cardiovascular events independent of left ventricular hypertrophy. 5 However, the current study is a longitudinal analysis from the Campania Salute Network to investigate whether a specific phenotype at baseline can predict changes in ARD in participants with essential hypertension. 6 In addition, they investigated the effects of antihypertensive treatment on the normalisation or progression of ADR in these participants.…”

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confidence: 99%

“…The authors also calculated a predicted AR dimension and its generated z-score for each patient, using a previously defined formula. 5 The categorised AR dimension at follow-up was the end point considered in this study.…”

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confidence: 99%