Aortic dissection in cocaine abuse: A fatal case

D’Errico, Stefano; Niballi, S.; Bonuccelli, Diana

doi:10.1016/j.jflm.2018.07.001

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…A previous IRAD report showed only 0.5% (5/921) patients with aortic dissection had a history of cocaine use in 2002 [ 207 ], while this proportion increased to 1.8% (63/3584) in 2014 [ 210 ]. Noting that IRAD study only recruited in-hospital patients while numbers of case report and autopsy study proved that a large number of cocaine users died of aortic dissection and rupture outside hospitals [ 204 , 213 , 214 , 215 , 216 ], leading to the concern about underestimated cocaine-use prevalence in both IRAD studies. However, the updated IRAD study found that cocaine-use patients had a higher risk of type B AAD (2.4%, 30/1252) than type A AAD (1.4%, 33/2332), which is consistent with a previous study [ 209 ].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Thoracic Aortic Dissection

Zhou

Cecchi

Prakash

et al. 2022

Genes

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Thoracic aortic aneurysms involving the root and/or the ascending aorta enlarge over time until an acute tear in the intimal layer leads to a highly fatal condition, an acute aortic dissection (AAD). These Stanford type A AADs, in which the tear occurs above the sinotubular junction, leading to the formation of a false lumen in the aortic wall that may extend to the arch and thoracoabdominal aorta. Type B AADs originate in the descending thoracic aorta just distal to the left subclavian artery. Genetic variants and various environmental conditions that disrupt the aortic wall integrity have been identified that increase the risk for thoracic aortic aneurysms and dissections (TAD). In this review, we discuss the predominant TAD-associated risk factors, focusing primarily on the non-genetic factors, and discuss the underlying mechanisms leading to TAD.

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Section: Introductionmentioning

confidence: 99%

Risk Factors for Thoracic Aortic Dissection

Zhou

Cecchi

Prakash

et al. 2022

Genes

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Cocaine-Related Aortic Dissection: what do we know?

Greve

Funke

Khairi

et al. 2020

Braz J Cardiovasc Surg

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Introduction Cocaine use is known to be associated with an increased risk for vascular diseases. It is likely to trigger or increase the risk for an aortic dissection. We conducted an analysis of 45 cases of cocaine-related aortic dissection to further characterize the clinical features and outcomes of this patient cohort. Methods Our study cohort of 45 patients consisted of 11 cases from our institutional database and 34 published case reports. Results The observed cases of acute aortic dissection related to cocaine use showed a high proportion of young (41.3±8.67 years) and male (88.9%) patients. Most of the cases (75%) were classified as Stanford type A. Also, in 75% of the cases, cocaine use was prevalent for more than one year. Median time from last cocaine use to onset of symptoms was one hour. In-hospital mortality was 21.4%, while additional 11.9% of the cases died before arriving at the hospital. Conclusion Acute aortic dissection related to cocaine use occurs in predominantly young male patients and has a dismal outcome when compared to all comer series.

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Aortic dissection in cocaine abuse: A fatal case

Cited by 2 publications

References 38 publications

Risk Factors for Thoracic Aortic Dissection

Risk Factors for Thoracic Aortic Dissection

Cocaine-Related Aortic Dissection: what do we know?

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