Aortic dissection

Buivydaitė, Kristina; Semėnaitė, Vaida; Braždžionytė, Julija; Macas, Andrius

doi:10.3390/medicina44030032

Cited by 4 publications

(6 citation statements)

References 13 publications

(24 reference statements)

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“…Aortic dissection (AD) is a fatal vascular disease in which blood enters the middle layer of the vessel wall through a tear in the inner lining of the aortic wall and forms a dissecting hematoma along the aortic wall [ 1 ]. The incidence of aortic coarctation is 0.005% to 0.03% per year [ 2 , 3 ]. It is common, but the mortality rate is high.…”

Section: Introductionmentioning

confidence: 99%

SERPINE1 Gene Is a Reliable Molecular Marker for the Early Diagnosis of Aortic Dissection

Liu

Xiao

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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With the acceleration of population aging, the detection rate of aortic dissection has increased. The incidence rate of aortic dissection has increased year by year and has become a serious threat to human health. However, the current clinical treatment of aortic dissection is mainly limited to surgery (including intracavity), but the complexity of the disease and the high risk of surgery seriously affect the overall treatment effect of the disease. Therefore, an in-depth study of the pathogenesis of aortic dissection and the development of early diagnosis methods is not only expected to control the development of aortic dissection but also to improve the existing clinical treatment effect. Based on the bioinformatics analysis of the related mRNA sequence data of aortic dissection in GEO database, the gene expression regulatory network of aortic dissection was constructed. Through the screening of key node genes, the key factors (molecular markers) that may affect the occurrence of aortic dissection were obtained, and their functions were tested in human aortic smooth muscle cells (HAoSMC). Finally, it was concluded that SERPINE1 gene is a reliable molecular marker for the early diagnosis of aortic dissection.

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Section: Introductionmentioning

confidence: 99%

SERPINE1 Gene Is a Reliable Molecular Marker for the Early Diagnosis of Aortic Dissection

Liu

Xiao

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…AAD is an acute lesion of the aortic wall, accompanied by separation of the intimal and medial layers of this artery, due to rupture or intramural hematoma [ 1 ]. It is a very serious vascular event with a high mortality rate.…”

Section: Discussionmentioning

confidence: 99%

“…Acute aortic dissection (AAD) is a highly lethal cardiovascular emergency with an incidence of 2000 new cases per year in the United States and 3000 in Europe. The rate of incidence is 5–30 per million people per year and the mortality rate is 3.2/100.000 per year [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Aortic aneurysm with complete atrioventricular block and acute coronary syndrome

Palmeira¹,

Ribeiro

Lira

et al. 2016

BMC Res Notes

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BackgroundAcute aortic dissection (AAD) is a highly lethal and prevalent cardiovascular emergency. AAD can develop into atrioventricular conductivity disorders caused by coronary artery dissection, with acute myocardial infarction (AMI) being the most frequent clinical sign. In many deceased patients, the diagnosis is not confirmed until autopsy, and 85 % receive the wrong therapy as a result of misdiagnosis.Case presentationA 49-year-old male patient presenting with prolonged, intense and sharp precordial pain radiating to his back, as well as cold sweats, nausea and vomiting, was admitted to the cardiac emergency service. Thorax examination revealed normal bilateral breath sounds and a respiratory frequency of 24 incursions/min (SpO2 97 %). Cardiac auscultation revealed a heartbeat that was rhythmic, regular, and bradycardic. There was a visible high-intensity pulsation in the suprasternal notch, a diastolic murmur audible at the aortic focus, and a fourth heart sound on auscultation. The patient was diagnosed with Stanford type A AAD, concomitant complete atrioventricular block, and impairment of the right coronary artery, progressing to acute coronary syndrome (ACS) and spontaneous rupture of the aortic aneurysm. After a hemodynamic study, the patient was transferred for urgent surgical treatment and passed away during the procedure.ConclusionPhysical examination is essential to be able to disregard AAD as the main cause of AMI. The consequences of a misdiagnosis can be fatal if thrombolytic or anticoagulant therapy is chosen as the initial treatment; therefore, surgery is the best treatment for aortic dissection.

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“…Aortic dissection (AD) is a rare, life-threatening condition with a worldwide mortality rate of 3.2 per 100 000 people, per year. 1 It commonly presents initially with the acute onset of severe chest, abdominal or back pain. Clinical manifestations presenting primarily as acute onset of paraplegia, acute skeletal muscle necrosis or acute kidney failure with painless AD are particularly rare, 1 with few reports in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…1 It commonly presents initially with the acute onset of severe chest, abdominal or back pain. Clinical manifestations presenting primarily as acute onset of paraplegia, acute skeletal muscle necrosis or acute kidney failure with painless AD are particularly rare, 1 with few reports in the literature. AD characterized by the acute onset of paraplegia, oliguria or muscle pain is often misdiagnosed as various other conditions, such as acute myelitis or spinal haemorrhage, acute kidney failure, polymyositis or even multiple organ failure of unknown cause, leading to a delay in diagnosis and an increase in mortality.…”

Section: Introductionmentioning

confidence: 99%

Aortic Dissection Presenting Primarily as Acute Spinal Cord Damage: A Case Report and Literature Review

Rb¹,

Zhang

2012

J Int Med Res

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Acute aortic dissection is a rare, life-threatening condition. Clinical manifestations generally include the acute onset of severe chest or back pain. Aortic dissection presenting with signs and symptoms of acute spinal cord damage is the most severe complication and is particularly rare. This paper reports a case of aortic dissection in a 50-year-old man with a 10-year history of hypertension manifesting as acute spinal cord damage (bilateral lower extremity weakness and loss of all types of sensation), acute skeletal muscle ischaemic necrosis with increased levels of creatine kinase, and acute kidney failure with increased levels of serum creatinine and decreased glomerular filtration rate. The patient refused surgical treatment. His clinical condition progressively worsened and he died 3 days later. This case indicates the importance of considering aortic dissection in patients presenting with acute spinal cord damage, acute skeletal muscle necrosis or acute kidney failure, which may allow early diagnosis and reduce the mortality rate.

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Aortic dissection

Cited by 4 publications

References 13 publications

SERPINE1 Gene Is a Reliable Molecular Marker for the Early Diagnosis of Aortic Dissection

SERPINE1 Gene Is a Reliable Molecular Marker for the Early Diagnosis of Aortic Dissection

Aortic aneurysm with complete atrioventricular block and acute coronary syndrome

Aortic Dissection Presenting Primarily as Acute Spinal Cord Damage: A Case Report and Literature Review

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