“… 5 Physical examination findings of aortopulmonary fistula formation include a widened pulse pressure, a continuous cardiac murmur that has been described as “machinery-like” and sometimes localized to the left second and third intercostal spaces, and clinical signs of right ventricular volume overload due to the large degree of left-to-right shunting. 7 , 8 , 9 Similar to congenital aortopulmonary windows, patients with aortopulmonary fistulas can develop left ventricular dilation, pulmonary hypertension, and heart failure due to unrestricted shunting. TTE is commonly the first diagnostic modality, particularly using color flow Doppler interrogation to assess for continuous (systolic and diastolic) high-velocity flow.…”