AOP Report: Inhibition of Chitin Synthase 1 Leading to Increased Mortality in Arthropods

Abstract

Pathways and Predictions articles are summaries of multi-process biological responses to chemicals described by extensive datasets. Adverse outcome pathways (AOPs) are one example of this where comprehensive compilations of concepts and evidence comprising a given AOP can be obtained from an open-source AOP Wiki (aopwiki.org).

Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations

“…AOP developers prepare a peer-reviewed publication in the format of a citable AOP report ( O'Brien and Yauk, 2022 ). The first AOP reports were published recently (AOP 296 ( Cho et al, 2022 ), AOP 263 ( Song and Villeneuve, 2021 ), AOP 360 ( Schmid et al, 2021 )). Development of memorandums of understanding with additional journals are ongoing.…”

“…Considering the scope of the HBM4EU project and the expertise of the partners involved, the present paper focuses on human health. It should, however, be highlighted that AOPs were initially proposed as a tool in the environmental ecotoxicological hazard and risk assessment ( Ankley et al, 2010 ), and there are many examples of AOP use in this context ( Fay et al, 2017 , Legradi et al, 2018 , Schmid et al, 2021 , Song and Villeneuve, 2021 , Toyota et al, 2022 , Volz et al, 2011 ). Likewise, some of the considerations presented in this manuscript are valid for both human and ecological RA.…”

Comparative Transcriptome Analysis on the Regulatory Mechanism of Thoracic Ganglia in Eriocheir sinensis at Post-Molt and Inter-Molt Stages

“…DDC catalyzes the conversion of dopa into dopamine and then initiates the subsequent process of exoskeleton sclerotization and mineralization [ 26 ]. CS catalyzes chitin biosynthesis and plays a regulatory role in the development of the cuticular layer [ 27 ]. In this study, CS was significantly upregulated to promote the formation of the new carapace.…”

Linking freshwater ecotoxicity to damage on ecosystem services in life cycle assessment

“…This is based on data from ecotoxicity tests, extrapolated to structural ecosystem properties (i.e., populations and communities) and some ES of importance for human wellbeing, whereby current uncertainties in this assessment process are reflected in the magnitude of uncertainty factors utilized in the derivation of environmental quality standards that aim to ascertain sufficient protection even under data uncertainties ( Forbes et al, 2017 ). However, with the current advancement in mechanistic models and quantitative adverse outcome pathways (AOPs), predictive ecotoxicology is continuously advancing ( Forbes et al, 2017 , Schmid et al, 2021 ), such that impacts that may occur when those standards are exceeded are increasingly quantified (e.g., Posthuma et al, 2019 ).…”

“…1 , AOPs complement the AESP framework and can be useful for linking ecotoxicity effects to damage on species and functional diversity loss. AOP describes initiating key effects, followed by series of subsequent events, eventually leading to impaired functions in an organism, thereby defining relationships within the AESP concept and providing helpful information in predicting and quantifying impacts up to the community level ( Schmid et al, 2021 ). Although emphasis in the present review is on expanding towards eventual ES damage, the framework in Fig.…”