Ao Philosophy and Principles of Fracture Management—its Evolution and Evaluation☆

Helfet, David L.; Haas, Norbert; Schatzker, J.; Matter, P; Moser, R.; Hanson, Beate

doi:10.2106/00004623-200306000-00029

Cited by 93 publications

(74 citation statements)

References 8 publications

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“…With few exceptions, the best method to achieve anatomic reduction and rigid fixation in adult horses is open reduction and compressive plate fixation using techniques. The advantages are well‐established and include improved survival, reduced morbidity associated with prolonged periods of cast immobilization, reduced support limb complications and better functional outcomes . The main disadvantages of plate fixation compared to non‐operative methods, including cast immobilization, are expense of surgery and potential for surgical site infection.…”

Section: Discussionmentioning

confidence: 99%

Plate fixation for management of plantar instability of the distal tarsus/proximal metatarsus in 5 horses

McCormick

Watkins

2014

Veterinary Surgery

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Section: Discussionmentioning

confidence: 99%

Plate fixation for management of plantar instability of the distal tarsus/proximal metatarsus in 5 horses

McCormick

Watkins

2014

Veterinary Surgery

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“…Conservative techniques of treating fractures of the tibial plateau were common in the past but many of these techniques resulted in poor outcomes and even caused lifelong disability in many cases [12]. A revolution in the operative treatments of these injuries was introduced by the AO Foundation [12,13], which led to the development of different reconstruction techniques [9,14], including minimally invasive options through arthroscopy.…”

Section: Discussionmentioning

confidence: 99%

“…A revolution in the operative treatments of these injuries was introduced by the AO Foundation [12,13], which led to the development of different reconstruction techniques [9,14], including minimally invasive options through arthroscopy. Because of these new developments, the number of reconstructions of tibial plateau fractures has increased significantly in recent years [9,13,14].…”

Section: Discussionmentioning

confidence: 99%

Minimally invasive reconstruction of lateral tibial plateau fractures using the jail technique: a biomechanical study

Weimann

Heinkele

Herbort

et al. 2013

BMC Musculoskelet Disord

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BackgroundThis study described a novel, minimally invasive reconstruction technique of lateral tibial plateau fractures using a three-screw jail technique and compared it to a conventional two-screw osteosynthesis technique. The benefit of an additional screw implanted in the proximal tibia from the anterior at an angle of 90° below the conventional two-screw reconstruction after lateral tibial plateau fracture was evaluated. This new method was called the jail technique.MethodsThe two reconstruction techniques were tested using a porcine model (n = 40). Fracture was simulated using a defined osteotomy of the lateral tibial plateau. Load-to-failure and multiple cyclic loading tests were conducted using a material testing machine. Twenty tibias were used for each reconstruction technique, ten of which were loaded in a load-to-failure protocol and ten cyclically loaded (5000 times) between 200 and 1000 N using a ramp protocol. Displacement, stiffness and yield load were determined from the resulting load displacement curve. Failure was macroscopically documented.ResultsIn the load-to-failure testing, the jail technique showed a significantly higher mean maximum load (2275.9 N) in comparison to the conventional reconstruction (1796.5 N, p < 0.001). The trend for better outcomes for the novel technique in terms of stiffness and yield load did not reach statistical significance (p > 0.05). In cyclic testing, the jail technique also showed better trends in displacement that were not statistically significant. Failure modes showed a tendency of screws cutting through the bone (cut-out) in the conventional reconstruction. No cut-out but a bending of the lag screws at the site of the additional third screw was observed in the jail technique.ConclusionsThe results of this study indicate that the jail and the conventional technique have seemingly similar biomechanical properties. This suggests that the jail technique may be a feasible alternative to conventional screw osteosynthesis in the minimally invasive reconstruction of lateral tibial plateau fractures. A potential advantage of the jail technique is the prevention of screw cut-outs through the cancellous bone.

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“…[4, 5] With sterile operation and perioperative antibiotic defenses, the risk of infection after internal fixation ranges between 0.4% and 16.1% depending on the extent of fracture. [6] To be more precise, the infection rates of periprosthetic joint infections (PJIs) are 0.5–2%, [7] 2–9% [8] and 0.3–1.7% [9] after total joint replacement of the knee, hip and ankle, respectively. Staphylococcus aureus (S.aureus) is one of the most frequent microorganisms causing implant infections, and implant associated infection is considered to be the most serious complications of prosthetic implants.…”

Section: Introductionmentioning

confidence: 99%

Toward a Molecular Understanding of the Antibacterial Mechanism of Copper‐Bearing Titanium Alloys against Staphylococcus aureus

Zhu

et al. 2015

Adv Healthcare Materials

146

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The antibacterial mechanism of the Cu-containing materials has not been fully understood although such understanding is crucial for the sustained clinical use of Cu-containing antibacterial materials such as bone implants. The aim of this study is to investigate the molecular mechanisms by which the Gram-positive Staphylococcus aureus (S.aureus) is inactivated through Cu-bearing titanium alloys (Ti6Al4V5Cu). Cu ions released from the alloys were found to contribute to lethal damage of bacteria. They destroyed the permeability of the bacterial membranes, resulting in the leakage of reducing sugars and proteins from the cells. They also promoted the generation of bacteria-killing reactive oxygen species (ROS). The ROS production was confirmed by several assays including fluorescent staining of intracellular oxidative stress, detection of respiratory chain activity, and measurement of the levels of lipid peroxidation, catalase and glutathione. Furthermore, the released Cu ions showed obvious genetic toxicity by interfering the replication of nuc (species-specific) and 16SrRNA genes, but with no effect on the genome integrity. All of these effects lead to the antibacterial effect of Ti6Al4V5Cu. Collectively, our work reconciles the conflicting antibacterial mechanisms of Cu-bearing metallic materials or nanoparticles reported in the literature, as well as highlight the potential use of Ti6Al4V5Cu alloys in inhibiting bacterial infections.

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Ao Philosophy and Principles of Fracture Management—its Evolution and Evaluation☆

Cited by 93 publications

References 8 publications

Plate fixation for management of plantar instability of the distal tarsus/proximal metatarsus in 5 horses

Plate fixation for management of plantar instability of the distal tarsus/proximal metatarsus in 5 horses

Minimally invasive reconstruction of lateral tibial plateau fractures using the jail technique: a biomechanical study

Toward a Molecular Understanding of the Antibacterial Mechanism of Copper‐Bearing Titanium Alloys against Staphylococcus aureus

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