Anxiolytic-like effect of succinic acid in mice

Chen, Si Wei; Xin, Qin; Kong, Wei Xi; Li, Min; Li, Jing Fang

doi:10.1016/j.lfs.2003.06.017

Cited by 41 publications

(23 citation statements)

References 21 publications

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“…The plus-maze was elevated to a height of 40 cm above floor level by a single central support. Four 25 W red fluorescent lights arranged as a cross at 100 cm above the maze were used as the source of illumination (Chen et al, 2003). The experiment was conducted during the dark phase of the light cycle (9:00-14:00 h).…”

Section: Elevated Plus-maze Testmentioning

confidence: 99%

Anxiolytic effect of saponins from Panax quinquefolium in mice

Wei

Yang

Wang

et al. 2007

Journal of Ethnopharmacology

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Section: Elevated Plus-maze Testmentioning

confidence: 99%

Anxiolytic effect of saponins from Panax quinquefolium in mice

Wei

Yang

Wang

et al. 2007

Journal of Ethnopharmacology

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“…Succinic acid (SA) is a product of the metabolism of plants and micro-organisms (WANG et al, 2011) and has shown biological activities, such as anxiolytic (CHEN, 2003;VOLCHEGORSKII et al, 2015), and the induction for IL-8 production in inflammatory processes (GRAHAM et. al., 2013).…”

Section: Parasiticmentioning

confidence: 99%

Ovicidal activity of succinic acid isolated from sisal waste (Agave sisalana) against gastrointestinal nematodes of goats

Santos

et al. 2017

Cienc. Rural

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This study was conducted to evaluate the in vitro anthelmintic activity of the succinic acid (SA) isolated from sisal waste against gastrointestinal nematodes of goats, using the egg hatching and larvae motility assays. In addition, potential cytotoxicity of SA on Vero cell cultures was investigated by means of MTT (3-4,5-dimethylthiazol-2-yl, 2,5diphenyltetrazolium bromide) test. The SA induced a significant inhibition of egg hatching (P<0.05) at all concentrations tested (60 to 250µg mL-1), and the concentrations to inhibit 50% (EC50) and 90% (EC90) values (mean ± standard deviation) were 90.3±2.8 and 130.6±3.5µg mL-1, respectively. The SA has not shown larvicidal activity. The SA was less toxic to the Vero cells, with the mean percentage of cell viability equal to 85±6.2% at the concentration of 130µg mL-1. The results suggested that SA has potential anthelmintic effect; although, more research is needed to confirm its activity in vivo.

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“…A study conducted by Chen et al 74 on a behavioural animal model in rat demonstrated that oral administration of pure succinic acid (3 and 6 mg/kg body weight) may have anxiolytic activity, although higher doses failed to produce that effect.…”

Section: Evolution Of Amber Use In Medicinementioning

confidence: 99%

Amber, a Stone of Sun for Ancient Medicines

Ragazzi¹

2016

AMHR

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Anxiolytic-like effect of succinic acid in mice

Cited by 41 publications

References 21 publications

Anxiolytic effect of saponins from Panax quinquefolium in mice

Anxiolytic effect of saponins from Panax quinquefolium in mice

Ovicidal activity of succinic acid isolated from sisal waste (Agave sisalana) against gastrointestinal nematodes of goats

Amber, a Stone of Sun for Ancient Medicines

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