Anxiolytic-like effect of phytoestrogen genistein in rats with long-term absence of ovarian hormones in the black and white model

The aqueous crude extract of Montanoa frutescens produces anxiolytic-like effects similarly to diazepam in Wistar rats: Involvement of GABAA receptor

“…Besides, the aforementioned profile is associated with anxiolytic-like activity (D'Aquila et al, 2000). Additionally, rearing was not significantly affect with the anxiolytic doses used in both experiments, which suggest that this variable is not sufficiently sensible to anxiolytic agents including diazepam, as previously reported (Rodríguez-Landa et al, 2009b). Respect to higher doses of Mf or diazepam (75 or 4 mg/kg, respectively) exhibited a diminished grooming and rearing behaviors consistent with the sedative effects produced by both treatments in this behavioral test.…”

“…Reduction of grooming behavior is prevented by anxiolytic drugs, returning it to values of unstressed animals (Hata et al, 1988;D'Aquila et al, 2000). This effect is considered as an additional indicator of an anxiolytic-like effect at experimental level and can be produced by diazepam and others substances with well-characterized anxiolytic potency (Hata et al, 1988;Rodríguez-Landa et al, 2009b). In the present study, the vehicle group showed the lower levels of grooming, an effect possibly associated to the stress induced by previous session in the elevated plus-maze, which also has been reported in other studies using the light/dark test previous to evaluation in open field test (Rodríguez-Landa et al, 2009b).…”

“…This effect is considered as an additional indicator of an anxiolytic-like effect at experimental level and can be produced by diazepam and others substances with well-characterized anxiolytic potency (Hata et al, 1988;Rodríguez-Landa et al, 2009b). In the present study, the vehicle group showed the lower levels of grooming, an effect possibly associated to the stress induced by previous session in the elevated plus-maze, which also has been reported in other studies using the light/dark test previous to evaluation in open field test (Rodríguez-Landa et al, 2009b). Interestingly, 50 mg/kg of Mf or 2 mg/kg of diazepam maintains grooming behavior while in antagonism experiment show only a non-significant tendency to increase grooming but effects of picrotoxin pretreatment on this variable were no detected.…”

Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

“…This phytoestrogen also showed more ainity for ERβ than ERα [69], and recent reports also suggested that it binds to ERm. Rodríguez-Landa et al [70]) assayed several doses of this compound (0.25, 0.5 and 1.0 mg/kg, i.p.) after 4 days of administration in Wistar rats with 12-weeks after the elimination of ovaries.…”

Introductory Chapter: A Multidisciplinary Look at Menopause

“…Therapeutic alternatives mainly consist of dietary supplements that contain natural compounds, such as phytoestrogens, including isolavones, lavones, lignans, coumestans, and stilbenes. Preclinical studies have shown that the phytoestrogen genistein reverses anxiety-like behavior in an experimental model of surgical menopause [20] and depression-like behavior [21].…”