Anxiolytic-like and sedative actions of<i>Rollinia mucosa</i>: Possible involvement of the GABA/benzodiazepine receptor complex

Estrada-Reyes, Rosa; López‐Rubalcava, Carolina; Rocha, Luísa; Heinze, Gerardo; Esquinca, Alma Rosa Gonzalez; Martínez‐Vázquez, Mariano

doi:10.3109/13880200903046153

Cited by 21 publications

(12 citation statements)

References 19 publications

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“…There are several reports which demonstrated that the alkaloids, glycosides, and flavonoids rich plant and plant extracts possess sedative, anxiolytic, and antiepileptic properties mediated through their affinity ( in vitro ) with benzodiazepine site of GABAergic complex system or are direct or indirect modulators of this receptor [25–29]. Besides, nonspecific CNS depression can also be attributed by tannin [30].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract ofScoparia dulcisLinn.

Moniruzzaman

Rahman

Ferdous

2015

Evidence-Based Complementary and Alternative Medicine

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Scoparia dulcis Linn. (SD) is a perennial herb that has been well studied for its antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective effects. However, scientific information on SD regarding the neuropharmacological effect is limited. This study evaluated the sedative and hypnotic effect of the ethanolic extract of whole plants of Scoparia dulcis (EESD). For this purpose, the whole plants of S. dulcis were extracted with ethanol following maceration process and tested for the presence of phytochemical constituents. The sedative and hypnotic activity were then investigated using hole cross, open field, hole-board, rota-rod, and thiopental sodium-induced sleeping time determination tests in mice at the doses of 50, 100, and 200 mg/kg of EESD. Diazepam at the dose of 1 mg/kg was used as a reference drug in all the experiments. We found that EESD produced a significant dose-dependent inhibition of locomotor activity of mice both in hole cross and open field tests (P < 0.05). Besides, it also decreased rota-rod performances and the number of head dips in hole-board test. Furthermore, EESD significantly decreased the induction time to sleep and prolonged the duration of sleeping, induced by thiopental sodium. Taken together, our study suggests that EESD may possess sedative principles with potent hypnotic properties.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract ofScoparia dulcisLinn.

Moniruzzaman

Rahman

Ferdous

2015

Evidence-Based Complementary and Alternative Medicine

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“…However, only the combined treatment was able to protect mice against excitotoxic injury providing potential therapeutic applications for brain trauma, brain ischemia, epilepsy and Alzheimer’s disease. Extracts from Rollinia mucosa leaves were analyzed for BDZ receptor binding by in vitro autoradiography and single administration in mice [ 42 ]. The study revealed reduced binding activity in the hippocampus (29%), amygdala (26%) and temporal cortex (36%).…”

Section: Effect Of Plant Extracts On Cns Receptors and Therapeuticmentioning

confidence: 99%

Interaction of Plant Extracts with Central Nervous System Receptors

Lundström¹,

Pham

Dinh

2017

Medicines

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Background: Plant extracts have been used in traditional medicine for the treatment of various maladies including neurological diseases. Several central nervous system receptors have been demonstrated to interact with plant extracts and components affecting the pharmacology and thereby potentially playing a role in human disease and treatment. For instance, extracts from Hypericum perforatum (St. John’s wort) targeted several CNS receptors. Similarly, extracts from Piper nigrum, Stephania cambodica, and Styphnolobium japonicum exerted inhibition of agonist-induced activity of the human neurokinin-1 receptor. Methods: Different methods have been established for receptor binding and functional assays based on radioactive and fluorescence-labeled ligands in cell lines and primary cell cultures. Behavioral studies of the effect of plant extracts have been conducted in rodents. Plant extracts have further been subjected to mood and cognition studies in humans. Results: Mechanisms of action at molecular and cellular levels have been elucidated for medicinal plants in support of standardization of herbal products and identification of active extract compounds. In several studies, plant extracts demonstrated affinity to a number of CNS receptors in parallel indicating the complexity of this interaction. In vivo studies showed modifications of CNS receptor affinity and behavioral responses in animal models after treatment with medicinal herbs. Certain plant extracts demonstrated neuroprotection and enhanced cognitive performance, respectively, when evaluated in humans. Noteworthy, the penetration of plant extracts and their protective effect on the blood-brain-barrier are discussed. Conclusion: The affinity of plant extracts and their isolated compounds for CNS receptors indicates an important role for medicinal plants in the treatment of neurological disorders. Moreover, studies in animal and human models have confirmed a scientific basis for the application of medicinal herbs. However, additional investigations related to plant extracts and their isolated compounds, as well as their application in animal models and the conducting of clinical trials, are required.

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“…Our phytochemical screening of EEGO revealed the presence of alkaloids, carbohydrates, flavonoids, glycosides, saponins, and tannins ( Table 1 ), where saponins are known to show amphetamine antagonism and sedative property and decrease spontaneous motor activity in the experimental animal models [ 26 ]. It has also been reported that the presence of alkaloids, glycosides, and flavonoids in plant extract possess sedative and anxiolytic effect through the interaction with GABA A receptors [ 27 – 29 ]. Considering our results and previously published reports, it is possible that the abovementioned chemical components in the extract might contribute at least in part to the observed pharmacological activities.…”

Section: Resultsmentioning

confidence: 99%

Sedative and Anxiolytic‐Like Actions of Ethanol Extract of Leaves of Glinus oppositifolius (Linn.) Aug. DC.

Moniruzzaman

Bhattacharjee

Pretty

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Glinus oppositifolius is a small herb, widely used in the traditional medicine of Bangladesh in treatment of a variety of diseases and disorders such as insomnia, pain, inflammation, jaundice, and fever. The present study evaluated the sedative and anxiolytic potentials of the ethanol extract of leaves of G. oppositifolius (EEGO) in different behavioral models in mice. The sedative activity of EEGO was investigated using hole cross, open field, rotarod, and thiopental sodium- (TS-) induced sleeping time determination tests, where the elevated plus maze (EPM) and light-dark box (LDB) exploration tests were employed to justify the anxiolytic potentials in mice at the doses of 50, 100, and 200 mg/kg. The results demonstrated that EEGO significantly inhibited the exploratory behavior of the animals both in hole cross and in open field tests in a dose-dependent manner. It also decreased motor coordination and modified TS-mediated hypnosis in mice. In addition, EEGO showed anxiolytic potential by increasing the number and time of entries in the open arm of EPM, which is further strengthened by increase in total time spent in the light part of LDB. Therefore, this study suggests the sedative and anxiolytic properties of the leaves of G. oppositifolius and supports the traditional use of this plant in treatment of different psychiatric disorders including insomnia.

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Anxiolytic-like and sedative actions ofRollinia mucosa: Possible involvement of the GABA/benzodiazepine receptor complex

Cited by 21 publications

References 19 publications

Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract ofScoparia dulcisLinn.

Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract ofScoparia dulcisLinn.

Interaction of Plant Extracts with Central Nervous System Receptors

Sedative and Anxiolytic‐Like Actions of Ethanol Extract of Leaves of Glinus oppositifolius (Linn.) Aug. DC.

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