Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study

Bhattacharya, S. K.; Bhattacharya, Alok; Krishnamurthy, Sairam; Ghosal, Shibnath

doi:10.1016/s0944-7113(00)80030-6

Cited by 253 publications

(153 citation statements)

References 13 publications

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“…Ashwagandha also exhibited an antidepressant effect comparable to that induced by imipramine in the forced swim-induced "behavioral despair" and "learned helplessness" tests (Bhattarcharya and Muruganandam, 2003). Other similar studies confirm these results, lending support to the use of ashwagandha as an antistress adaptogen (Bhattacharya et al, 2000;Bhattacharya et al, 2001;Singh et al, 2001). …”

Section: Anxiety and Depressionsupporting

confidence: 55%

Therapeutic use of Withania somnifera

Alam

Hoq

Uddin

2016

Asian J. Med. Biol. Res

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Abstract:Withania somnifera (L) Dunal is commonly called as Ashwagandha/Asgand and it belongs to the family Solanaceae. It is a well known medicinal plant widely used in the treatment of many clinical conditions in Indian subcontinent. It is an important medicinal plant commonly known as Asgand which has been used either single or in combination with other drugs in Unani as well as Ayurvedic system of medicine for centuries. It has been described by Dioscorides (78 AD) in his book "Kitab-ul-Hashaish". Asgand consists of the roots of Withania somnifera which has various therapeutic actions such as anti -inflammatory (Muhallil-e-Warm), sedative (Musakkin), aphrodisiac (Muqawwi-e-Bah), hepatoprotective, immune-modulator activity, antioxidant, anti-ageing, anti-tumour activity, adaptogenic activity and has anti-anticonvulsant activity. Keeping in view the medicinal properties of Withania somnifera Dunal (Asgand), an attempt has been made in this paper to explore various dimensions of the drug including phytochemical and pharmacological studies carried out on this herb.

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Section: Anxiety and Depressionsupporting

confidence: 55%

Therapeutic use of Withania somnifera

Alam

Hoq

Uddin

2016

Asian J. Med. Biol. Res

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“…for anxiolytic action. An anxiolytic effect was seen in the elevated plus-maze, social interaction and feeding latency in an unfamiliar environment, tests in WSG, comparable to that produced by lorazepam 36 .…”

Section: Effect On Central Nervous Systemmentioning

confidence: 65%

A Review on Adaptogenic Activity of Ashwagandha (Withania Somnifera): An Ayurvedic Appraisal

Shrilata¹,

Kumar²,

Chand³

et al. 2017

J Pharm Sci Innov.

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Stress is a state of mental or emotional strain resulting from demanding circumstances. It's a universal experience, which has an important defensive function towards harmful psychological stimuli. Owing to this there are various pharmacological and non-pharmacological treatments with fatal adverse reaction. The need of hour is to have a cost-effective adaptogenic drug. Adaptogens are compounds that increase the ability of an organism to adapt to environmental factors and avoid damage. Ayurveda explains these qualities under concepts of vyadhikshamatva (immunity). Ashwagandha is considered to be the best adaptogenic drug among shankhapushpi (Clitoria ternatea), yashtimadhu (Glycyrrhiza glabra), brahmi (Bacopa monnieri), guduchi (Tinospora cordifolia), mandookaparni (Centella asiatica), etc medhya dravya (cognitive enhancers). This study reviews the Ayurvedic and modern literature related to stress and its management as adaptogens through Ayurveda. Ayurveda is the traditional system of medicine of India and contains a very scientific description of stress and general manovikaras (psychiatric illness). Ayurveda has been a great potential in the field of rasayana (rejuvenation) as there are lots of single herbs and preparations which possess adaptogenic properties and strengthens the physiological adaptation.

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“…Earlier it was reported that, anxiolytic-antidepressant potential of W. somnifera and its glycowithanolides (Bhattacharya et al, 2000). Recent study reports also support the use of W. somnifera for depression and anxiety disorders.…”

Section: Antidepression and Antianxiety Activitymentioning

confidence: 79%

Chemistry and pharmacology of withania somnifera: An update

Kumar¹,

Dey²,

Hadimani³

et al. 2015

TANG [HUMANITAS MEDICINE]

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Withania somnifera (Ashwagandha) is an important Rasayana herb and widely considered as Indian ginseng in Ayurveda. In traditional system of Indian medicine, it is used as tonic to rejuvenate the body and increase longevity. In Ayurvedic preparations, various parts of the plant have been used to treat variety of ailments that affect the human health. However, dried roots of the plant are widely used for the treatment of nervous and sexual disorders. The major active chemical constituents of this plant are withanolides, which is responsible for its wide range of biological activities. Since the beginning of the 20 th century, a significant amount of research has been done and efforts are ongoing to further explore other bioactive constituents, and many pharmacological studies have been carried out to describe their disease preventing mechanisms. In this chapter, we have reviewed the chemistry and pharmacological basis of W. somnifera in various human ailments.

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Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study

Cited by 253 publications

References 13 publications

Therapeutic use of Withania somnifera

Therapeutic use of Withania somnifera

A Review on Adaptogenic Activity of Ashwagandha (Withania Somnifera): An Ayurvedic Appraisal

Chemistry and pharmacology of withania somnifera: An update

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