Therapeutic use of Withania somnifera

Alam, Khorshed; Hoq, Obydul; Uddin, Shahab

doi:10.3329/ajmbr.v2i2.29004

Cited by 4 publications

(2 citation statements)

References 12 publications

(13 reference statements)

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“…In the Unani system, the roots of Withania somnifera, known as Aswagandha are used for various medicinal purposes. The leaves of the plant are also reported to have been used medicinally (Alam et al, 2016).…”

Section: Therapeutic Importance Of Ashwagandhamentioning

confidence: 99%

A Discussion on the Therapeutic Importance of Medicinal Herbs and Benefits of Proteins Incorporated in XanthPro by Renatus

Dutta¹,

Kar²,

Shukla³

2023

Int J Med Sci Pharm Res

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Protein is one of the building blocks of bone, muscle, and skin. The body needs it to produce hormones, enzymes, and other chemicals. Eating protein-rich foods and taking supplements may help people feel fuller for longer. Feeling full tends to result in smaller portion sizes and less frequent snacking, which can help a person maintain a healthy weight. Due to a hectic lifestyle and poor eating habits, many of us may be lacking the required protein in our everyday diet. Renatus XanthPro is a unique protein supplement formulated with highly essential Vitamins & Minerals to give your body a fulfilling nutritional boost. The primary ingredient of this protein powder is Mangosteen (Garcinia mangostana)- a rich source of one of the rarest and most beneficial antioxidant families known as Xanthones. Xanthones have a broad spectrum of therapeutic properties such as- anti-oxidant, anti-tumor, anti-allergic, anti-inflammatory, anti-bacterial, anti-fungal and anti-viral activities. It is a low-fat composition that helps in weight management. It also contains prebiotic fibre and probiotics that enhance digestion and aid in faster absorption. It protects the body from free radical damage while boosting the energy levels and recovery. It also helps to maintain a healthy blood sugar level and increase the count of white Blood Cells (WBCs) in the blood. It is enriched with immunity-enhancing herbs that make it a better choice for complete wellness. These herbs are of ancient origin and are researched till date to extract more valuable properties in order to enhance human well-being. This review addresses the therapeutic importance of five such medicinal herbs which are an important composition of Xanthpro Protein powder. The inscribed herbs are Licorice (Glycyrrhiza glabra), Ashwagandha (Withania somnifera), Shatavari (Asparagus racemosus), Aloe-Vera (Aloe barbadensis miller) and Gotu Kola (Centella asiatica). Pharmacological experiments have demonstrated that different extracts and pure compounds from these species exhibit a broad range of biological properties. Therefore, the use of these herbal supplements in XanthPro, makes the protein powder to be used more reliably and widely. Overall, it gives our body nourishment as well as protection. It is not just a protein supplement, but is a volutionary step towards a healthy nation. Keywords: Protein, Renatus XanthPro, Mangosteen, Xanthones, Therapeutic, Immunity-enhancing herbs, Pharmacological, Soy Protein Isolate, Pea Protein Isolate.

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Section: Therapeutic Importance Of Ashwagandhamentioning

confidence: 99%

A Discussion on the Therapeutic Importance of Medicinal Herbs and Benefits of Proteins Incorporated in XanthPro by Renatus

Dutta¹,

Kar²,

Shukla³

2023

Int J Med Sci Pharm Res

View full text Add to dashboard Cite

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“…Withania somnifera (L.) Dunal, family Solanaceae, generally known as ashwagandha (ASH), is a perennial medicinal herb rich in steroidal lactones, saponins, alkaloids, flavonoids, and withanolides [ 6 ]. ASH has been applied to treat memory-related conditions and improve learning ability and memory capacity.…”

Section: Introductionmentioning

confidence: 99%

Ashwagandha-loaded nanocapsules improved the behavioral alterations, and blocked MAPK and induced Nrf2 signaling pathways in a hepatic encephalopathy rat model

Khalil

Al-Mokaddem

et al. 2022

Drug Deliv. and Transl. Res.

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Ashwagandha (ASH), a vital herb in Ayurvedic medicine, demonstrated potent preclinical hepato- and neuroprotective effects. However, its efficacy is limited due to low oral bioavailability. Accordingly, we encapsulated ASH extract in chitosan–alginate bipolymeric nanocapsules (ASH-BPNCs) to enhance its physical stability and therapeutic effectiveness in the gastrointestinal tract. ASH-BPNC was prepared by emulsification followed by sonication. The NCs showed small particle size (< 220 nm), zeta-potential of 25.2 mV, relatively high entrapment efficiency (79%), physical stability at acidic and neutral pH, and in vitro release profile that extended over 48 h. ASH-BPNC was then investigated in a thioacetamide-induced hepatic encephalopathy (HE) rat model. Compared with free ASH, ASH-BPNC improved survival, neurological score, general motor activity, and cognitive task-performance. ASH-BPNC restored ALT, AST and ammonia serum levels, and maintained hepatic and brain architecture. ASH-BPNC also restored GSH, MDA, and glutathione synthetase levels, and Nrf2 and MAPK signaling pathways in liver and brain tissues. Moreover, ASH-BPNC downregulated hepatic NF-κB immunohistochemical expression. Moreover, the in vivo biodistribution studies demonstrated that most of the administered ASH-BPNC is accumulated in the brain and hepatic tissues. In conclusion, chitosan–alginate BPNCs enhanced the hepatoprotective and neuroprotective effects of ASH, thus providing a promising therapeutic approach for HE. Graphical abstract

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