Anxiolytic- and antidepressant-like effects of an aqueous extract of Tanacetum parthenium L. Schultz-Bip (Asteraceae) in mice

Cárdenas, Jorge; Reyes‐Pérez, Valeria; Hernández-Navarro, María Dolores; Dorantes-Barrón, Ana María; Almazán, Salvador; Estrada-Reyes, Rosa

doi:10.1016/j.jep.2017.02.023

Cited by 21 publications

(8 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, it was displayed that having flavonoids including apigenin, the T. parthenium plant can interact with the benzodiazepine receptors including the GABA receptors and increase its activities. 13 In addition, in another study, the benzodiazepinic GABA activity of apigenin from the T. parthenium plant has been shown. 14 With the studies done in the field of active chemical compounds present in the TP, it has been identified that similar to the characteristics of T. parthenium, in this plant, abundant amount of flavonoids including apigenin and luteolin are found.…”

Section: Discussionmentioning

confidence: 93%

“…However, against this backdrop and in accordance with the findings of the present study, in the most recent study on T. parthenium , it was found that T. parthenium has anti‐anxiety and anti‐depression effects on the rats. Moreover, it was displayed that having flavonoids including apigenin, the T. parthenium plant can interact with the benzodiazepine receptors including the GABA receptors and increase its activities . In addition, in another study, the benzodiazepinic GABA activity of apigenin from the T. parthenium plant has been shown .…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

The anticonvulsant and neuroprotective effects of the Tanacetum Polycephalum hydroalcoholic extract against the experimental pentylenetetrazol‐induced model of the seizures in the male Wistar rats

Allahyari

Hosseini

Azizi

2019

Neurology & Clinical Neurosc

View full text Add to dashboard Cite

Background The genus Tanacetum is widespread in Europe and Western Asia. It is an important traditional plant which has been used in the treatment of many illnesses. Aim In the present study, the effect of the hydroalcoholic extract of Tanacetum polycephalum (henceforth TP) on the animal model of seizure was studied. Methods In this experimental study, 42 male Wistar rats weighing 220‐250 g were randomly selected and were divided to experimental and control groups (six rats per group). The experimental groups were treated by intraperitoneal (ip) single injection of 150, 300, 450, 600, and 750 mg kg−1 of hydroalcoholic extracts of TP. The control negative group received normal saline (0.9%) and the control positive group received phenobarbital (30 mg kg−1, ip) pretreatment. 30 minutes after the treatments, the seizure behaviors were evaluated by pentylenetetrazol (PTZ; 70 mg kg−1, ip) challenge. In addition, after experiment, the rats were put to death and brain was removed for the histological study. Results The ANOVA test was showed that compared to control group, all the TP doses delayed the initiation and duration of the tonic, clonic, and tonic‐clonic seizures and significantly reduced the tonic and clonic seizures (P < 0.001). Furthermore, the administration of all five doses of the extract significantly prevented the production of the dark neurons (P < 0.001) in different areas of the hippocampus compared to PTZ group. Conclusions We can conclude that the TP extract has beneficial effects on the prevention of the PTZ‐induced seizure.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 94%

The anticonvulsant and neuroprotective effects of the Tanacetum Polycephalum hydroalcoholic extract against the experimental pentylenetetrazol‐induced model of the seizures in the male Wistar rats

Allahyari

Hosseini

Azizi

2019

Neurology & Clinical Neurosc

View full text Add to dashboard Cite

show abstract

“…the number of head dippings and stretches number were also measure. In this model, a decrease in the percentage of time spent on the open arms and an increase in the percentage of time spent on the closed arms with respect to the control group are both associated with low anxiety levels [ 27 , 28 ].…”

Section: Methodsmentioning

confidence: 99%

Recovery of Naringin-Rich Flavonoid Extracts from Agroresidues with Anxiolytic- and Antidepressant-like Effects in Mice

et al. 2022

Self Cite

View full text Add to dashboard Cite

Citrus paradisi species belong to the Rutaceae family, and it is commonly known as grapefruit. Grapefruit consumption involves a large amount of waste that goes to landfills and produces significant pollution affecting the human health. To examine this phenomenon, we designed an efficient chemical method that recovers naringin-rich flavonoid extracts from the fresh waste of grapefruits, by using the solvent impregnation resin method (SIR) with XAD-4 amberlite and either methanol or water as elution systems. Additionally, we focused on evaluating these extracts’ anxiolytic- and antidepressant-like effects in behavioral predictive paradigms in mice. According to direct Principal Component Analysis (PCA) by NMR, and Direct Injection Electrospray Ionization-Mass Spectrometry (DIESI-MS), methanol extracts obtained after resin treatment were free of coumarin compounds and evinced had a high content of naringin. Poncirin, phenylalanine, chrysin 5,7-dimethyl ether, 5,7-dimethoxy-4′-hydroxyflavanone, 2,3-dihydro-2-(4-hydroxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, tetrahydrocurcumin, corchoionoside C, 6′-coumaroyl-1′-O-[2-(3,4-dihydroxyphenyl) ethyl]-β-D-glucopyranoside were also detected. Naringin-rich methanol extract caused a clear anxiolytic-like effect in the Elevated Plus Maze (EPM) and the Hole-Board (HBT) Tests, increasing oral doses of this extract did not produce a sedative effect. A single oral dose caused an antidepressant-like effect in the Tail Suspension Test (TST), while repeated administrations of the methanol extract elicited a robust antidepressant effect in the Forced Swimming Test (FST) in mice. Our evidence highlights the importance of bioprospecting studies of organic waste with therapeutic potentials, such as anxiety and depression disorders.

show abstract

“…The effect seems to be mediated by the serotonergic system [350] and is blocked by HT 2A receptor antagonists and serotonin synthesis inhibitors but not by βand α 2 -noradrenergic receptor antagonists, indicating that the extract modulates the release/reuptake of serotonin [351]. Tanacetum parthenium has exhibited anxiolytic and antidepressant-like effects in various tests, prompting the authors to propose the involvement of the GABAergic system [352]. Terminalia bellirica exerted its antidepressant-like effects (FST and TST) in mice through interaction with the adrenergic (α 1 ), dopaminergic (D 2 ), and serotonergic (release/reuptake of 5-HT) systems [353].…”

Section: Dosementioning

confidence: 99%

Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies

Moragrega

Rı́os

2021

Planta Med

View full text Add to dashboard Cite

Medicinal plants and their extracts are natural remedies with enormous potential for treating various diseases, including depression and anxiety. In the case of depression, hundreds of plants have traditionally been used in folk medicine for generations. Different plant extracts and natural products have been analyzed as potential antidepressant agents with validated models to test for antidepressant-like effects in animals, although other complementary studies have also been employed. Most of these studies focus on the possible mediators implicated in these potential effects, with dopamine, serotonin, and noradrenaline being the principal neurotransmitters implicated, both through interference with receptors and with their metabolism by monoamino oxidases, as well as through neuro-endocrine and neuroprotective effects. There are approximately 650 reports of antidepressant-like medicinal plants in PubMed; 155 of them have been compiled in this review, with a relevant group yielding positive results. Saffron and turmeric are the most relevant species studied in both preclinical and clinical studies; St. Johnʼs wort or kava have also been tested extensively. To the best of our knowledge, no review to date has provided a comprehensive understanding of the biomolecular mechanisms of action of these herbs or of whether their potential effects could have real benefits. The purpose of this narrative review is to provide an update regarding medicinal plants from the year 2000 to the present to examine the therapeutic potential of these antidepressant-like plants in order to contribute to the development of new therapeutic methods to alleviate the tremendous burden that depression causes worldwide.

show abstract

Anxiolytic- and antidepressant-like effects of an aqueous extract of Tanacetum parthenium L. Schultz-Bip (Asteraceae) in mice

Abstract: Anxiolytic- and antidepressant-like T. parthenium effects result, at least part from the involvement of the GABAergic system. Our results support the use of Tanacetum parthenium in traditional medicine and suggest its therapeutic potential in the comorbid anxiety and depression.

Cited by 21 publications

References 42 publications

The anticonvulsant and neuroprotective effects of the Tanacetum Polycephalum hydroalcoholic extract against the experimental pentylenetetrazol‐induced model of the seizures in the male Wistar rats

The anticonvulsant and neuroprotective effects of the Tanacetum Polycephalum hydroalcoholic extract against the experimental pentylenetetrazol‐induced model of the seizures in the male Wistar rats

Recovery of Naringin-Rich Flavonoid Extracts from Agroresidues with Anxiolytic- and Antidepressant-like Effects in Mice

Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies

Contact Info

Product

Resources

About