Anxiogenic Behavior in the Light–Dark Paradigm Following Intraventricular Administration of Cholecystokinin-8S, Restraint Stress, or Uncontrollable Footshock in the CD-1 Mouse

MacNeil, Glenda; Sela, Yael; McIntosh, Judith Frances; Zacharko, Robert M.

doi:10.1016/s0091-3057(97)00037-3

Cited by 38 publications

(29 citation statements)

References 39 publications

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“…PDE4BÀ/À mice displayed decreases in head-dips and time spent in head-dipping in the holeboard test, an increase in latency before crossing to the light side and decreases in transitions and time spent in the light compartment in the light-dark transition test, and an increase in latency to explore and decreases in exploration and rears in a novel and lighted open-field chamber. All these changes represent typical anxiogenic-like behavior (MacNeil et al, 1997;Pellow, 1986;Suaudeau et al, 2000). Given that PDE4BÀ/À mice did not display significant changes in locomotor activity, as evidenced by unaltered total line crossings in the open-field test, the behavioral effects of PDE4B deficiency on anxiety tests appeared not to be attributed to sedation.…”

Section: Discussionmentioning

confidence: 91%

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Anxiogenic-Like Behavioral Phenotype of Mice Deficient in Phosphodiesterase 4B (PDE4B)

Zhang

Huang

Masood

et al. 2007

Neuropsychopharmacol

157

143

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Phosphodiesterase-4 (PDE4), an enzyme that catalyzes the hydrolysis of cyclic AMP and plays a critical role in controlling its intracellular concentration, has been implicated in depression-and anxiety-like behaviors. However, the functions of the four PDE4 subfamilies (PDE4A, PDE4B, PDE4C, and PDE4D) remain largely unknown. In animal tests sensitive to anxiolytics, antidepressants, memory enhancers, or analgesics, we examined the behavioral phenotype of mice deficient in PDE4B (PDE4BÀ/À). Immunoblot analysis revealed loss of PDE4B expression in the cerebral cortex and amygdala of PDE4BÀ/À mice. The reduction of PDE4B expression was accompanied by decreases in PDE4 activity in the brain regions of PDE4BÀ/À mice. Compared to PDE4B + / + littermates, PDE4BÀ/À mice displayed anxiogenic-like behavior, as evidenced by decreased head-dips and time spent in head-dipping in the holeboard test, reduced transitions and time on the light side in the light-dark transition test, and decreased initial exploration and rears in the open-field test. Consistent with anxiogenic-like behavior, PDE4BÀ/À mice displayed increased levels of plasma corticosterone. In addition, these mice also showed a modest increase in the proliferation of neuronal cells in the hippocampal dentate gyrus. In the forced-swim test, PDE4BÀ/À mice exhibited decreased immobility; however, this was not supported by the results from the tail-suspension test. PDE4BÀ/À mice did not display changes in memory, locomotor activity, or nociceptive responses. Taken together, these results suggest that the PDE4B subfamily is involved in signaling pathways that contribute to anxiogenic-like effects on behavior.

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Section: Discussionmentioning

confidence: 91%

“…The test was performed as described previously (MacNeil et al, 1997). Mice were individually placed in the dark compartment (15 Â 23 cm) of the light-dark chamber.…”

Section: Anxiogenic-like Effects On Behaviormentioning

confidence: 99%

Anxiogenic-Like Behavioral Phenotype of Mice Deficient in Phosphodiesterase 4B (PDE4B)

Zhang

Huang

Masood

et al. 2007

Neuropsychopharmacol

157

143

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“…Preclinical studies provide potential insight into such mechanisms. In animals, stress exacerbates or sensitized subsequent anxiety-like responses in a number of anxiety models involving severe or chronic the stressor (3-6), but sensitized anxiety can be found even immediately after a single acute stressor (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Acute Stress Potentiates Anxiety in Humans

Grillon

Dunčko

Covington³

et al. 2007

Biological Psychiatry

101

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“…It is well know that the endogenous CCKergic activity, or the CCKR-2 level in the brain, plays a dominant role in the expression of anxiety. For example, the expression of anxiety was correlated with the increased CCKergic tone, which was evidenced by a higher CCK receptor-binding capacity in the brain of anxious animals, in comparison with non-anxious animals [129][130][131]. Different fear responses among different strains of the same animal species were attributed to different expression levels of CCKR-2 [132][133][134].…”

Section: Discussionmentioning

confidence: 99%

“…For example, CCK-4-induced panic status in healthy volunteers significantly increases HPA axis activities [86]. Even the effects of early-life stress on HPA axis function are found to be associated with CCK sensitivity 130 . Most interestingly, interactions between the CCKergic system and the CRF/HPA system exist [88][89][90].…”

Section: Introductionmentioning

confidence: 99%

CCKergic System, Hypothalamus-Pituitary-Adrenal (HPA) Axis, and Early-Life Stress (ELS)

Tang¹,

Joseph²,

Chen³

et al. 2012

Glucocorticoids - New Recognition of Our Familiar Friend

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Anxiogenic Behavior in the Light–Dark Paradigm Following Intraventricular Administration of Cholecystokinin-8S, Restraint Stress, or Uncontrollable Footshock in the CD-1 Mouse

Cited by 38 publications

References 39 publications

Anxiogenic-Like Behavioral Phenotype of Mice Deficient in Phosphodiesterase 4B (PDE4B)

Anxiogenic-Like Behavioral Phenotype of Mice Deficient in Phosphodiesterase 4B (PDE4B)

Acute Stress Potentiates Anxiety in Humans

CCKergic System, Hypothalamus-Pituitary-Adrenal (HPA) Axis, and Early-Life Stress (ELS)

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