Acute Stress Potentiates Anxiety in Humans

Grillon, Christian; Dunčko, Roman; Covington, Matthew F.; Kopperman, Lori; Kling, Mitchel A.

doi:10.1016/j.biopsych.2007.06.007

Cited by 101 publications

(78 citation statements)

References 27 publications

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“…Stress typically heightens anxiety (Bremne and Vermetten, 2001;Grillon et al, 2007;Lupien et al, 2009;Pechtel and Pizzagalli, 2011), perhaps through modulation of GABAergic systems in the BLA. There are tantalizing hints that single stress (Rodriguez Manzanares et al, 2005;Isoardi et al, 2007) and repeated stress may subtly impair GABAergic regulation in the BLA of adult rodents (Reznikov et al, 2008(Reznikov et al, , 2009Gilabert-Juan et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Zhang

Rosenkranz

2016

Neuropsychopharmacol

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The adolescent age is associated with lability of mood and emotion. The onset of depression and anxiety disorders peaks during adolescence and there are differences in symptomology during adolescence. This points to differences in the adolescent neural circuitry that underlies mood and emotion, such as the amygdala. The human adolescent amygdala is more responsive to evocative stimuli, hinting to less local inhibitory regulation of the amygdala, but this has not been explored in adolescents. The amygdala, including the lateral nucleus (LAT) of the basolateral amygdala complex, is sensitive to stress. The amygdala undergoes maturational processes during adolescence, and therefore may be more vulnerable to harmful effects of stress during this time period. However, little is known about the effects of stress on the LAT during adolescence. GABAergic inhibition is a key regulator of LAT activity. Therefore, the purpose of this study was to test whether there are differences in the local GABAergic regulation of the rat adolescent LAT, and differences in its sensitivity to repeated stress. We found that LAT projection neurons are subjected to weaker GABAergic inhibition during adolescence. Repeated stress reduced in vivo endogenous and exogenous GABAergic inhibition of LAT projection neurons in adolescent rats. Furthermore, repeated stress decreased measures of presynaptic GABA function and interneuron activity in adolescent rats. In contrast, repeated stress enhanced glutamatergic drive of LAT projection neurons in adult rats. These results demonstrate age differences in GABAergic regulation of the LAT, and age differences in the mechanism for the effects of repeated stress on LAT neuron activity. These findings provide a substrate for increased mood lability in adolescents, and provide a substrate by which adolescent repeated stress can induce distinct behavioral outcomes and psychiatric symptoms.

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Section: Introductionmentioning

confidence: 99%

Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Zhang

Rosenkranz

2016

Neuropsychopharmacol

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“…Tel: +2347066509471. chronic stress and it occurs through persistent activation of limbic-hypothalamo-pituitary-adrenal axis and the secretion of stress hormones in the brain (Cordero et al, 2003;Grillon et al, 2007). Stress-related behavioural activities and haematological responses may be triggered for a long period by an exposure to psychological/ emotional stressor (Armario et al, 2008;Shin and Liberzon, 2010).…”

Section: Introductionmentioning

confidence: 99%

Behavioural and haematological studies on effects of lycopene in Wistar rats subjected to psychological stress

Ogundeji¹,

Ayo²,

Aluwong³

et al. 2013

J. Neurosci. Behav. Health

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This study investigated the effects of prior lycopene supplementation on behaviour and haematology of Wistar rats subjected to psychological stress. Four groups of Wistar rats, each comprising seven animals were investigated: unstressed (U-Control), unstressed + lycopene (U+Lyco), stressed (SControl) and stressed + lycopene (S+Lyco). Olive oil was given by oral gavage to each rat in the groups, either singly or mixed with 10 mg/kg lycopene daily for two weeks. S-Control and S+Lyco groups were subjected to psychological stress followed by behavioural assessment using excitability score test. Blood samples were collected after sacrificing the animals and then analyzed. Psychological stress increased (P < 0.05) erythrocyte malondialdehyde (MDA) concentration in Wistar rats. Lycopene significantly increased excitability scores and total blood plasma proteins, and decreased (P > 0.05) erythrocyte MDA concentration. In conclusion, antioxidant properties of lycopene may be attenuating the effects of psychological stress on excitability score and erythrocytes of Wistar rats.

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“…El otro nivel de activación se relaciona con la liberación de glucocorticoides; los cuales han sido identificados como los compuestos a través de los cuales se integran, la ansiedad y el miedo (Grillon et al, 2007). Ante un estímulo adverso de observa un incremento en la actividad cerebral, así como en el sistema nervioso periférico por liberación de glucocorticoides (Rodrígues et al, 2009).…”

Section: Regiones Cerebrales Involucradas En El Miedo Y La Ansiedadunclassified

Modelos animales de miedo y ansiedad: descripciones neuro-conductuales

Gallegos

Castillo

2014

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Modelos animales de miedo y ansiedad: descripciones neuro-conductualesResumen. Los modelos animales de miedo y ansiedad se han utilizado para la comprensión de trastornos de ansiedad en humanos, sin embargo no ha sido fácil diferenciar ambos conceptos a nivel fisiológico y conductual. Una forma de modelar estos trastornos es mediante pruebas conductuales de ansiedad (como el laberinto en cruz elevado o la prueba de campo abierto) y de miedo (como el condicionamiento al miedo y la evitación activa). Además, estos modelos permiten estudiar diferentes áreas cerebrales involucradas como la amígdala, el hipocampo y la corteza prefrontal. En general, el miedo y la ansiedad se pueden considerar respuestas adaptativas normales, sin embargo niveles elevados de ambos pueden generar consecuencias perjudiciales para el individuo. Palabras clave. Modelos animales, ansiedad, miedo, comportamiento.Abstract. Animal models of fear and anxiety have been widely used for the comprehension of anxiety disorders in humans, however, it has not been easy to distinguish between both concepts at physiological and behavioral levels. One way to model anxiety disorders is through behavioral tests of anxiety, (such as the elevated plus maze and the open field test), and fear (using the fear conditioning paradigm and active avoidance). Furthermore, animal models are relevant to study the involvement of different brain areas, like the amygdala, hippocampus and prefrontal cortex. In general, fear and anxiety can be considered as normal adaptive responses; however, elevated levels of both might generate detrimental consequences for the individual.

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Acute Stress Potentiates Anxiety in Humans

Abstract: Background-Stress is an important factor in the development and maintenance of anxiety disorders. Stress also potentiates anxiety-like response in animals, but empirical evidence for a similar effect in humans is still lacking.

Cited by 101 publications

References 27 publications

Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Behavioural and haematological studies on effects of lycopene in Wistar rats subjected to psychological stress

Modelos animales de miedo y ansiedad: descripciones neuro-conductuales

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